Samir M. Gharib

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
14 Mar 24	SPRB Spruce Biosciences	RSU Common Stock	Grant	Acquire A	No	No	0	154,000	0.00	154,000
29 Dec 23	SPRB Spruce Biosciences	Common Stock	Grant	Acquire A	No	No	0.9775	11,255	11.00 k	202,776
15 Dec 23	SPRB Spruce Biosciences	Common Stock	Payment of exercise	Dispose F	No	No	1.66	12,882	21.38 k	191,521
15 Dec 23	SPRB Spruce Biosciences	Common Stock	Option exercise	Acquire M	No	No	0	37,250	0.00	204,403
15 Dec 23	SPRB Spruce Biosciences	Common Stock	Payment of exercise	Dispose F	No	No	1.66	23,213	38.53 k	167,153
15 Dec 23	SPRB Spruce Biosciences	Common Stock	Option exercise	Acquire M	No	No	0	75,000	0.00	190,366
15 Dec 23	SPRB Spruce Biosciences	RSU Common Stock	Option exercise	Dispose M	No	No	0	37,250	0.00	111,750
15 Dec 23	SPRB Spruce Biosciences	RSU Common Stock	Option exercise	Dispose M	No	No	0	75,000	0.00	75,000
14 Dec 23	SPRB Spruce Biosciences	RSU Common Stock	Grant	Acquire A	No	No	0	308,000	0.00	308,000
8 Nov 23	SPRB Spruce Biosciences	RSU Common Stock	Grant	Acquire A	No	No	0	75,000	0.00	75,000

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.