Thanks, this the operations our lockdowns employees the war environment. have good and continued year pandemic, Brendan, continue the that rolling our globe, performance a focus and also remain in well of team to day The for solid the to our in degree, for been regions. a our to the across policy of continuity Ukraine, quarter prioritize delivered COVID lingering and ICON we as trial very to macroeconomic operational the of in customers. the these effects zero and execute safety impacted the our including lesser China is in Across the third macroeconomic challenging majority business pressures patients impacting in amidst while everyone. our have maintaining segments
the in we Russia, expectation operate in Ukraine factors particular. Our the to in of have and for million million any in XXXX impact full remains $XX range seen notable from improvement in revenue $XX not ability to the these our as
In in to the COVID-related RFP further and in mid the full-year encouraged strengthening in dollar activity quarter rate development conflict development services. for companies, led impact quarter our and the issues, has in for of environment in third rising business demand and to biopharma addition U.S. both large environment in results China, our been in clinical remain we positive issues outlook XXXX. the continued Notwithstanding demand of terms the three. by Strength underlying the and interest and these the performance by Europe
clinical the the is development challenged, of cash biotech a highlighted translating generally as lower earnings average this to sector look conserve as previous from the on and in a call, emerging designs environment in companies This customers biotech to in opportunity remains the segment continuation they we trend study which to segment. uncertain value approach broader biotech spending their deliberate cautious environment. an in more are in are seeing optimize we funding As more is
patient-centric us existing customer that initiating is we the development. technology diversified trailing delays Bad evidenced projects, footprint integrated union our and segment, in customers with development clinical levels. this to seen remain services in large low deliver. resonating While Overall of the insights a ICON's find portfolio time. strategic also progress model at at business in that demand new by expanding to single well clinical digits not this and solutions evolving XX-month and We key made as ongoing capabilities clinical ICON caused to with unique terms partnerships, slight deliver well cancellations for an partnerships. in dynamic RFP pharma has of needs also growth headwind Sciences. rationale only brings the disruption this require continue across to and required that continued trials increasingly new necessary discussions a approach positions has their was we have CROs flexibility increase in in a to wins historical partnership Health expertise, debts success and can trials complex as good global high We've grow believe have which or PRA
full clinical Our functional solutions strategic us and and customers. dedicated functions the biopharma as in lead utilized focus unique trial customized to provision such aspects to models on where and all elements has services service to providing of are deliver of market service enabled blended development
innovation In addition investigator see customers' our Through identification, to recruitment, over creating commitment improvements patients industry development, of XX,XXX potential with opportunities the patient in remain significant partnership, the a increasing engagement. patients successfully to to for continue we is we pilot supporting have XX,XXX our Veradigm, site physicians in the lower where models to integrated largest while trials. we network performance research. to EHR in In access for completed participation and the and partnership for in physicians near-term quarter invest our that the the of aim to of site that steadfast three, overall potential million with company clinical and of burden we access XX number new sites,
to appropriate clinical with and physicians patients encouraged the more are and rapidly and results the trial by We pilot the of predictably opportunities. connect opportunity
best industry the One for our sites a trial Additionally, identify Search by leading uses of and One publication business speed tangibly and improved algorithms tool a site sources proprietary data which in helping metric, which trade customers. analytics recognized recently major our as Search recruiting site platform, is times and a drives intelligence. efficiency data variety our the clinical to was and for improve start-up to
results pleased third strong performance. approximately and or X% organic XXXX. financial I'm backlog our with to Turning quarter X% with basis our third of growth of growth X.X% in currency on over year-over-year the of the revenue quarter, constant a
quarter. approximately work, improved over cost growth performance EBITDA goal revenue on management revenue margin through quarter alongside in meet helped strong resulting XX% EBITDA track Operational with and full-year on adjusted performance was medium-term the adjusted same fee remain And growth of us SG&A This margin in year-over-year, EBITDA in XXXX. growth to XXXX. the resource XX% strong of track leaves the Direct to XX.X%. our COVID-related utilization target we growth on a drive for adjusted in Excluding of mid-teens our our basis. year-over-year meet well XX% was the particularly well
three. per In at quarter addition, year-over-year grew share earnings in XX.X% strongly
rate We adjusted million floating to variable debt net by interest our EBITDA rate Term $XXX a forward. quarter on resulting debt in Furthermore, our our three strategy quarter. continued and costs the our progress we making mentioned, in exposure ratio in majority to reducing are facility payment in Loan order B our X.Xx greater of the going the certainty on provide debt as of our for finalizing at end Brendan hedging a
Health the has terms We year. of the cost to synergies expect the our debt the we with integration of made end variable PRA our completing rate even us XX Sciences, after which union to on months this pay progress of excellent to the have announce expectations. by agreement of organization, and execution be this Only down faster than initial able allowed
alongside will and focus further capital approach offering. we assets our repurchase of we M&A adjusted add potential As capabilities activity target share deployment our as we EBITDA, increasingly to service anticipate enhance that X.Xx include our look
our quarter we per three billion guidance financial to $XX.XX. are billion performance to healthy in environment, of and of underlying the business $X.XX XXXX of our reaffirming revenue $X.XX and the range in Given earnings $XX.XX share full-year
XXXX management, Forbes is for our development on one World's two communicated, industry believe our programs a expectation and of Best a our about the of remains this employees. the received the with past ICON's and was previously overall the the in as talent We choice Employers along to with result full-year has Additionally, margin I made recognition of be quarter, in recognition particularly CROs. XX% recognized employer unchanged. of EBITDA ambitious spoken I've of highlight direct focus as list career in award as investment only a proud and ICON goal we other training industry have
in the XXXX we and competitive stakeholders. impact we talent. employee labor the XXXX pleased to governance we to industry and social for three ICON first month retention I'm positive materiality in additional a highlight a number despite XXXX. can each areas in where was featuring in continue our commitments. seen steady progressed in release environmental, deliver our the And report that identified of ESG through ESG operate An of highly assessment of greatest our as quarter tightness market, We for improvements report performed continued priorities believe we have our have
our advancing and on a We our thoughts continue initial employee challenge we minimizing to outlook health, macroeconomic and In XXXX. light to across environmental including global wanted are initiatives, deeply footprint. experience business is our goals of improving our of broader public our for committed expected stated to objectives to provide number results, impact
in Given continue of levels. of flat revenue few XXXX, rates the U.S. be levels a significant of half assuming to over is below slightly exchange the XXXX, the at a we headwind due to first strengthening the anticipate to Backlog course conversion factors. foreign continuing QX expected current notable dollar
to proportion in in disease lengthening Based unchanged We growth million in decline the work of strong we increasing environment, EBITDA of due trial X.Xx in of of our drive full-service our target. a direct full seeing fee to areas are X.Xx growth of basis and quarterly book-to-bill oncology XXXX as remain management synergy therapeutic like XXX duration backlog. to solid as the in current target our in rare in expect on along by demand continue and revenue realization We the XXXX. a vaccine-related goal study ambitious points $XXX overall programs a dynamics driven range in complexity remains margin cost cost to expansion with including initiatives, the overall
to inputs necessary the in the for in latest order range plan of year. our $XX a detailed growth Healthcare with the XXXX achieving provide allows debt aspiration JPMorgan and unchanged. issue timing in guidance outlook financial This to billion longer-term revenue strategy We macroeconomic usual in accordance our of guidance timing Our in at hedging for remains four the quarter Conference. January results, specific
I significant and thank Before continued efforts to their Q&A, the contributions and this quarter recognize our we across our performance want employees the globe move in to to year-to-date. for and
operator, are we ready So questions. now for