everyone, earnings our and for for Yes. us thank and Thanks, call you, Marty, joining XXXX corporate quarter first update.
provided recently and be our Investor remarks a pipeline we As at today. will with my Day, brief strategic March I update full
Scientific Let our me then and the programs, minutes with take our review hand high-level Marty also provide financial Marty to We'll Officer. first Chief floor I'll where John to call to pipeline the back and again Q&A, by status joined the quarter a comments on open Nuss, be some results. few of to then our I'll
our with NLRPX positive multiple-ascending Phase in begin and novel our potential I NLRPX announced a VTXXXXX, healthy top trial volunteers. inhibitor I'll So from we of CNS-penetrant of adult dose In results best-in-class inhibitors. portfolio line March, single-
all both beta both as achieved coverage IL-X steady-state beta milligrams IL-X X CSF. once milligrams CSF plasma doses the you milligrams in remember, ICXX the as way up As coverage XX low QD, exceeded and and repeat to XX repeat well and doses of ICXX may VTXXXXX plasma daily in
that in target estimate to low XX-milligram modeling, in on ICXX dose and as be data CSF Based on VTXXXXX our once coverage doses daily the projection we beta these adequate IL-X plasma. may as achieve
observed showed in ex dose-dependent this I also tolerability -- stimulation vivo also excellent an robust We study. or whole PD in assay. excellent a And IL-X showed Phase profile blood pharmacodynamic VTXXXXX beta effects
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we trial which disease trials patients year. need, VTXXXXX As the VTXXXXX to also indications we in communicated with this Phase second with initiate will Phase advance half of March, plan of into rapidly the II with early in unmet in we in IIa high-value beginning substantial Parkinson's
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important potentially due loss also obese has buzz published in mice. of and showing much NLRPX and a for February as metabolic target weight it NLRPX-mediated much diseases, recently, last More central created data obesity discussion obesity-related to
obesity similar We of initiated studies in our about. model talked models VTXXXXX we own have neuroi the with diet-induced just to published
agonist these update exciting later GLP-X to VTXXXXX are These on induced combination with also study, weight providing assessing loss in to by and and we we're semaglutide monotherapy in addition the evaluating second studies quarter. a in an VTXXXXX look In with the studies, forward semaglutide.
II XXXX factors. of the cardiovascular trial participants now second risk initiate So to plan We of during moving half additional with humans. to from obese Phase in mice certain VTXXXXX a
our current from trial March, we VTXXXXX, with this moving to of In in our cryoprin-associated periodic restricted as VTXXXXX VTXXXXX peripherally A or biologics, fibrinogen. comparable IL-X, observed IL-X In with Now line high-sensitive of standard NLRPX serum inflammatory trial, syndromes results positive that care. such HSCRP, biomarkers demonstrated CAPS. also and to II CRP, inhibitor. Phase robust on top patients announced demonstrated VTXXXXX amyloid efficacy the reductions consistent in and
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need. And March, represent we indications or cardiovascular VTXXXXX communicated on in and also unmet major with an in MACE. adverse prevention and events substantial medical development pericarditis focus pericarditis, future prevention indication for in initial secondary other evaluate as we cardiovascular MACE recurrent and to recurrent the markets large of RP, plan addressable and Both potentially with
our thus, an development plans in on plan we, update cardiovascular year. or provide to update So this later
our SXPX for in potential advancing allosteric modulator Beyond VTXXXX, TYKX Phase development of II ulcerative inhibitor for team Crohn's continues best-in-class receptor assets, our portfolio, and to colitis NLRPX progress including inhibitor disease. IBD make the the or treatment our VTXXXX,
potential October a includes XXXX, colitis. believe agent oral For we recall profile we VTXXXX, rate Phase profile. is endoscopic This and best-in-class of an that in differentiated demonstrating II announced positive highly you'll best-in-disease safety a potential for complete ulcerative remission of a in data what
that and from we the trial, for perhaps long-term for is III extension our the also ongoing. program II March part improved profile. to from anticipate the Phase endoscopic continue observed in data period. of show induction ready, the and extension of preliminary trial this II make event, Phase remission continue even the This Phase showed XX-week differentiated reinforcing data or XX-week endoscopic sustained open-label is preparations pivotal Phase will the teams remission fully III study to from our data the part further that the data At We
with meeting with this of advice scientific later conduct we EMA a expect productive the month, the meeting to completed and quarter. Last a Phase we X End FDA,
with continue to to completion we successful underway II are have efforts previously that trial pivotal completed a a trial pivotal this of have as indicated, We second to source sufficient other ulcerative of non-dilutive approval of partner III Phase And financing confidence be in identify VTXXXX to may colitis. our support or XX-week support trial. Phase
trial Finally, TYKX our VTXXXX, inhibitor our Phase Crohn's active moderately allosteric severe II progress. of disease to to continues and
quarter streamline in of year, in of to implemented As a amendment signal we've protocol this this mentioned the potential detection a efficacy first we trial.
now baseline XXX Crohn's in of the point at and XX. week index disease XX or approximately the change protocol result amendment, enrollment CDAI patients the trial's a the activity was from to main from primary patients, end approximately is revised As target score sole
to enrollment completed of reporting March, line early have and second half look top we in trial We forward results XXXX. in in the
So their members and I like and continued our to pipeline again all that in conclusion, across and the collaborators would in for contributions the across our our Ventyx all to trials. thank efforts team of investigators enroll patients
We a are updates. to productive for to looking much year continue and Ventyx provide to forward very these exciting
hand -- our now for financial call of a results. financial review of our brief I'll Marty quarter Marty? first the to back