CRISPR Therapeutics (CRSP)

Cash burn rate (est.)	Burn method: Change in cash		Burn method: Operating income		Burn method: FCF (opex + capex)
	Last Q	Avg 4Q	Last Q	Avg 4Q	Last Q	Avg 4Q
Cash on hand (at last report)	309.78 mm	309.78 mm	309.78 mm	309.78 mm	309.78 mm	309.78 mm
Cash burn (monthly)	(no burn)	7.61 mm	21.53 mm	38.88 mm	16.68 mm	11.90 mm
Cash used (since last report)	n/a	16.07 mm	45.47 mm	82.12 mm	35.22 mm	25.13 mm
Cash remaining	n/a	293.71 mm	264.31 mm	227.66 mm	274.55 mm	284.65 mm
Runway (months of cash)	n/a	38.6	12.3	5.9	16.5	23.9

Beta Read what these cash burn values mean

Financial data from company earnings reports.

Institutional ownership, Q4 2024

CRSP institutional ownership history Ownership history

92.8% owned by funds/institutions

13F holders	Current	Prev Q	Change
Total holders	403	417	-3.4%
Opened positions	68	44	+54.5%
Closed positions	82	80	+2.5%
Increased positions	112	128	-12.5%
Reduced positions	116	127	-8.7%

13F shares	Current	Prev Q	Change
Total value	2.32 tn	2.54 tn	-8.8%
Total shares	79.61 mm	74.52 mm	+6.8%
Total puts	1.92 mm	1.90 mm	+1.5%
Total calls	1.55 mm	1.10 mm	+41.1%
Total put/call ratio	1.2	1.7	-28.1%

Largest owners	Shares	Value	Change
ARK Investment Management	8.97 mm	$353.18 bn	+19.7%
Capital International Investors	8.74 mm	$344.15 bn	+10.3%
VRTX Vertex Pharmaceuticals	5.38 mm	$353.37 mm	0.0%
T. Rowe Price Investment Management	3.81 mm	$150.03 mm	+39.2%
GSK GSK	3.31 mm	$278.46 mm	0.0%
Bayer Global Investments B.V.	2.95 mm	$154.89 mm	0.0%
BlackRock	2.76 mm	$108.61 bn	-1.3%
CMTDF Sumitomo Mitsui Trust	2.75 mm	$108.07 bn	-7.5%
Nikko Asset Management Americas	2.75 mm	$108.07 bn	-7.5%
STT State Street	2.49 mm	$98.07 bn	-16.8%

Largest transactions	Shares	Bought/sold	Change
Orbis Allan Gray	1.48 mm	+1.48 mm	NEW
ARK Investment Management	8.97 mm	+1.47 mm	+19.7%
UBS UBS	1.98 mm	+1.31 mm	+194.5%
T. Rowe Price Investment Management	3.81 mm	+1.07 mm	+39.2%
Capital International Investors	8.74 mm	+816.79 k	+10.3%
Contrarius Investment Management	0.00	-783.90 k	EXIT
BLVGF Bellevue	0.00	-610.00 k	EXIT
STT State Street	2.49 mm	-501.46 k	-16.8%
Baker Bros. Advisors	1.31 mm	+464.94 k	+55.1%
FHI Federated Hermes	0.00	-447.61 k	EXIT

Data from 13F filings, for the last complete 13F reporting period. For most recent data, click the ownership history button. Values as filed, not updated for current price. Long positions only.

Recent insider trades

CRSP insider ownership history Insider history

Date	Owner	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
26 Feb 25	Greene John	Common Shares	Buy	Acquire P	No	No	44.8497	7,000	313.95 k	7,000
19 Feb 25	Samarth Kulkarni	Common Shares	Sell	Dispose S	No	Yes	55.205	18,360	1.01 mm	171,613
19 Feb 25	Julianne Bruno	Common Shares	Sell	Dispose S	No	No	52.8	333	17.58 k	7,062
19 Feb 25	Samarth Kulkarni	Common Shares	Sell	Dispose S	No	No	52.8	6,928	365.80 k	189,973
19 Feb 25	Kasinger James R.	Common Shares	Sell	Dispose S	No	No	52.8	1,947	102.80 k	74,880
18 Feb 25	Julianne Bruno	Common Shares	Option exercise	Acquire M	No	No	0	650	0.00	7,395
18 Feb 25	Julianne Bruno	RSU Common Shares	Option exercise	Dispose M	No	No	0	650	0.00	650
18 Feb 25	Samarth Kulkarni	Common Shares	Sell	Dispose S	No	Yes	55.05	11,640	640.78 k	196,901
18 Feb 25	Samarth Kulkarni	Common Shares	Option exercise	Acquire M	No	No	0	13,250	0.00	208,541
18 Feb 25	Samarth Kulkarni	RSU Common Shares	Option exercise	Dispose M	No	No	0	13,250	0.00	13,250