Exhibit 16
April 30, 2012
U.S. Securities and Exchange Commission
Office of the Chief Accountant
100 F Street, NE
Washington, DC 20549
Re: Exact Sciences Corporation
File No. 000-32179
Dear Sir or Madam:
We have read Item 4.01 of Form 8-k of Exact Sciences Corporation dated April 30, 2012, and agree with the statements concerning our Firm contained therein.
Very truly yours,
/s/ Grant Thornton LLP