Genomic Health, Inc.
301 Penobscot Drive
Redwood City, California 94063
September 26, 2005
VIA EDGAR AND FACSIMILE
Securities and Exchange Commission
100 F Street, N.E.
Washington, D.C. 20549
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| Re: | | Genomic Health, Inc. |
| | | Registration Statement — Form S-1 (File No. 333-126626) |
Ladies and Gentlemen:
Pursuant to Rule 461 of the Securities Act of 1933, as amended, Genomic Health, Inc. (the “Registrant”) hereby requests that the Commission take appropriate action to cause the above-referenced Registration Statement on Form S-1, relating to the registration of 5,769,230 shares of the Registrant’s Common Stock, to become effective at 4:00 p.m. (Eastern Daylight Time) on September 28, 2005, or as soon thereafter as possible.
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| | GENOMIC HEALTH, INC.
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| | By: | /s/ G. Bradley Cole | |
| | | G. Bradley Cole, | |
| | | Executive Vice President and CFO | |
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| cc: | | G.A. Lombardi |
| | | J.D. Hovey |
