Document And Entity Information
Document And Entity Information - shares | 9 Months Ended | |
Sep. 30, 2016 | Nov. 02, 2016 | |
Document Information [Line Items] | ||
Document Type | 10-Q | |
Amendment Flag | false | |
Document Period End Date | Sep. 30, 2016 | |
Document Fiscal Year Focus | 2,016 | |
Document Fiscal Period Focus | Q3 | |
Entity Registrant Name | BIO-PATH HOLDINGS INC | |
Entity Central Index Key | 1,133,818 | |
Current Fiscal Year End Date | --12-31 | |
Entity Filer Category | Accelerated Filer | |
Trading Symbol | BPTH | |
Entity Common Stock, Shares Outstanding | 95,645,224 |
CONSOLIDATED BALANCE SHEETS
CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands | Sep. 30, 2016 | Dec. 31, 2015 |
Current assets | ||
Cash | $ 11,299 | $ 8,854 |
Prepaid drug product for testing | 196 | 560 |
Other current assets | 912 | 179 |
Total current assets | 12,407 | 9,593 |
Fixed assets | ||
Furniture, fixtures & equipment | 148 | 123 |
Less accumulated depreciation | (82) | (51) |
Property, Plant and Equipment, Net | 66 | 72 |
Other assets | ||
Technology licenses | 2,500 | 2,500 |
Less accumulated amortization | (1,531) | (1,410) |
Intangible Assets, Net (Excluding Goodwill), Total | 969 | 1,090 |
Total Assets | 13,442 | 10,755 |
Current liabilities | ||
Accounts payable | 118 | 54 |
Accrued expense | 748 | 883 |
Total current liabilities | 866 | 937 |
Warrant liability | 3,199 | 0 |
Total Liabilities | 4,065 | 937 |
Shareholders’ equity | ||
Preferred stock, $.001 par value 10,000,000 shares authorized, no shares issued and outstanding | 0 | 0 |
Common stock, $.001 par value, 200,000,000 shares authorized 95,645,224 and 89,762,872 shares issued and outstanding as of 9/30/16 and 12/31/15, respectively | 96 | 90 |
Additional paid in capital | 40,044 | 35,112 |
Accumulated deficit | (30,763) | (25,384) |
Total shareholders’ equity | 9,377 | 9,818 |
Total Liabilities & Shareholders’ Equity | $ 13,442 | $ 10,755 |
CONSOLIDATED BALANCE SHEETS (Pa
CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares | Sep. 30, 2016 | Dec. 31, 2015 |
Preferred Stock, par value | $ 0.001 | $ 0.001 |
Preferred Stock, shares authorized | 10,000,000 | 10,000,000 |
Preferred Stock, shares issued | 0 | 0 |
Preferred Stock, shares outstanding | 0 | 0 |
Common Stock, par value | $ 0.001 | $ 0.001 |
Common Stock, shares authorized | 200,000,000 | 200,000,000 |
Common Stock, shares issued | 95,645,224 | 89,762,872 |
Common Stock, shares outstanding | 95,645,224 | 89,762,872 |
CONSOLIDATED STATEMENTS OF OPER
CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2016 | Sep. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015 | |
Revenue | $ 0 | $ 0 | $ 0 | $ 0 |
Operating expenses | ||||
Research and development | 2,313 | 992 | 4,520 | 2,149 |
General and administrative | 681 | 520 | 2,287 | 1,873 |
Total operating expenses | 2,994 | 1,512 | 6,807 | 4,022 |
Net operating loss | (2,994) | (1,512) | (6,807) | (4,022) |
Other income | ||||
Change in fair value of warrant liability | 1,420 | 0 | 1,420 | 0 |
Interest income | 4 | 4 | 8 | 14 |
Total other income | 1,424 | 4 | 1,428 | 14 |
Net loss | $ (1,570) | $ (1,508) | $ (5,379) | $ (4,008) |
Net loss per share, basic and diluted | $ (0.02) | $ (0.02) | $ (0.06) | $ (0.04) |
Basic and diluted weighted average number of common shares outstanding | 95,645 | 89,763 | 91,724 | 89,763 |
CONSOLIDATED STATEMENTS OF CASH
CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended | |
Sep. 30, 2016 | Sep. 30, 2015 | |
Cash flow from operating activities | ||
Net loss | $ (5,379) | $ (4,008) |
Adjustments to reconcile net loss to net cash used in operating activities | ||
Amortization | 121 | 121 |
Depreciation | 31 | 31 |
Stock-based compensation | 550 | 283 |
Change in fair value of warrant liability | (1,420) | 0 |
(Increase) decrease in assets | ||
Prepaid drug product for testing | 364 | (250) |
Other current assets | (733) | (100) |
Increase (decrease) in liabilities | ||
Accounts payable and accrued expenses | (71) | (81) |
Net cash used in operating activities | (6,537) | (4,004) |
Cash flow from investing activities | ||
Purchase furniture, fixtures & equipment | (25) | 0 |
Net cash used in investing activities | (25) | 0 |
Cash flow from financing activities | ||
Net proceeds from sale of common stock | 9,007 | 0 |
Net cash provided by financing activities | 9,007 | 0 |
Net increase (decrease) in cash | 2,445 | (4,004) |
Cash, beginning of period | 8,854 | 13,859 |
Cash, end of period | $ 11,299 | $ 9,855 |
Organization and Business
Organization and Business | 9 Months Ended |
Sep. 30, 2016 | |
Organization, Consolidation and Presentation of Financial Statements [Abstract] | |
Organization and Business | Organization and Business The Company is a clinical and preclinical stage oncology focused antisense drug development company utilizing a novel technology that achieves systemic delivery for target specific protein inhibition for any gene product that is over-expressed in disease. The Company’s drug delivery and antisense technology, called DNAbilize, is a platform that uses P-ethoxy, which is a deoxyribonucleic acid (DNA) backbone modification that is intended to protect the DNA from destruction by the body’s enzymes when circulating in vivo, incorporated inside of a neutral charged lipid bilayer. The Company believes this combination allows for high efficiency loading of antisense DNA into non-toxic, cell-membrane-like structures for delivery of the antisense drug substance into cells. In vivo, the DNAbilize delivered antisense drug substances are systemically distributed throughout the body to allow for reduction or elimination of proteins in blood diseases and solid organs. Using DNAbilize as a platform for drug development and manufacturing, we currently have two antisense drug candidates in development to treat a total of five different disease indications. Our lead drug candidate, Liposomal Grb2 (“BP1001”), targets the protein Grb2 and has entered the efficacy portion of a Phase II clinical trial for acute myeloid leukemia (AML) and is preparing to enter the safety segment of a Phase II clinical trial for blast phase and accelerated phase chronic myelogenous leukemia (CML). BP1001 is also in preclinical studies for solid tumors, including triple negative breast cancer and inflammatory breast cancer. The Company’s second drug candidate, Liposomal Bcl2 (“BP1002”), targets the protein Bcl2, which is responsible for driving cell proliferation in up to 60% of all cancers. BP1002 is in preparation for an Investigational New Drug application. Bio-Path Subsidiary was founded in May 2007 as a Utah corporation. In February 2008, Bio-Path Subsidiary completed a reverse merger with Ogden Golf Co. Corporation, a public company traded over the counter that had no current operations. The name of Ogden Golf was changed to Bio-Path Holdings, Inc. and the directors and officers of Bio-Path, Inc. became the directors and officers of Bio-Path Holdings, Inc. The Company’s operations to date have been limited to organizing and staffing the Company, acquiring, developing and securing its technology and undertaking product development for a limited number of product candidates. 25.0 On June 29, 2016, the Company entered into the Securities Purchase Agreement with certain healthcare focused institutional investors pursuant to which the Company agreed to sell an aggregate of 5,882,352 2,941,176 10.0 9.3 0.3 As of September 30, 2016, Bio-Path had $11.3 million in cash on hand. As the Company has not begun its planned principal operations of commercializing a product candidate, the Company’s activities are subject to significant risks and uncertainties, including the potential requirement to secure additional funding, the outcome of the Company’s clinical trials, and failing to operationalize the Company’s current drug candidates before another company develops similar products. |
Recent Accounting Pronouncement
Recent Accounting Pronouncements | 9 Months Ended |
Sep. 30, 2016 | |
New Accounting Pronouncements and Changes in Accounting Principles [Abstract] | |
Recent Accounting Pronouncements | Recent Accounting Pronouncements In May 2014, the FASB issued Accounting Standards Update No. 2014-09, Revenue from Contracts with Customers. In February 2016, the FASB issued Accounting Standards Update No. 2016-02, Leases In March 2016, the FASB issued Accounting Standards Update No. 2016-09, Stock Compensation. Management has reviewed all other recently issued pronouncements and has determined they will have no material impact on the Company’s consolidated financial statements. |
Prepaid Drug Product for Testin
Prepaid Drug Product for Testing | 9 Months Ended |
Sep. 30, 2016 | |
Prepaid Drug Product For Testing [Abstract] | |
Prepaid Drug Product for Testing | Prepaid Drug Product for Testing Advance payments, including nonrefundable amounts, for goods or services that will be used or rendered for future clinical development activities are deferred and capitalized. Such amounts will be recognized as an expense as the related goods are delivered or the related services are performed. The Company incurred installments to its contract drug manufacturing and raw material suppliers totaling $ 0.6 0.2 |
Other Current Assets
Other Current Assets | 9 Months Ended |
Sep. 30, 2016 | |
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] | |
Other Current Assets | Other Current Assets As of September 30, 2016, Other Current Assets included prepaid expenses of $0.9 million, comprised primarily of prepayments made to the Company’s clinical research organization for our Phase II clinical trial for BP1001 in AML. As of December 31, 2015, Other Current Assets included prepaid expenses of $0.2 million. |
Accounts Payable
Accounts Payable | 9 Months Ended |
Sep. 30, 2016 | |
Accounts Payable Disclosure [Abstract] | |
Accounts Payable | 5. Accounts Payable As of September 30, 2016, Current Liabilities included accounts payable of $ 0.1 0.1 |
Accrued Expense
Accrued Expense | 9 Months Ended |
Sep. 30, 2016 | |
Accrued Liabilities [Abstract] | |
Accrued Expense | Accrued Expense 0.7 |
Warrant Liability
Warrant Liability | 9 Months Ended |
Sep. 30, 2016 | |
Derivative Liability [Abstract] | |
Warrant Liability Disclosure [Text Block] | 7. Warrant Liability In connection with the 2016 Registered Direct Offering, the Company issued warrants to purchase up to 2,941,176 250,000 Due to this provision and in accordance with ASC 480-10 (FASB Statement 150, Accounting for Certain Financial Instruments with Characteristics of both Liabilities and Equity), the 2016 Warrants were classified as a liability and recorded at fair value using the Binomial Lattice Model. The estimated fair value of the Warrant Liability for the 2016 Warrants on the closing date, July 5, 2016, was $ 4.6 3.2 1.4 |
Fair Value Measurements
Fair Value Measurements | 9 Months Ended |
Sep. 30, 2016 | |
Fair Value Disclosures [Abstract] | |
Fair Value Disclosures [Text Block] | Fair Value Measurements In accordance with ASC 820, the Company uses various inputs to measure the 2016 Warrants on a recurring basis to determine the fair value of the liability. ASC 820 also establishes a hierarchy categorizing inputs into three levels used to measure and disclose fair value. The hierarchy gives the highest priority to quoted prices available in active markets and the lowest priority to unobservable inputs. An explanation of each level in the hierarchy is described below: Level 1 Unadjusted quoted prices in active markets for identical instruments that are accessible by the Company on the measurement date Level 2 Quoted prices in markets that are not active or inputs which are either directly or indirectly observable Level 3 Unobservable inputs for the instrument requiring the development of assumptions by the Company Fair Value Measurements at September 30, 2016 (in thousands) Level 1 Level 2 Level 3 Total Liabilities: Warrant liability $ - $ - $ 3,199 $ 3,199 The Company did not have the 2016 Warrants at December 31, 2015. Fair Value of Warrant Liability (in thousands) Balance at December 31, 2015 $ - Issuance 4,619 Change in fair value (1,420) Balance at September 30, 2016 $ 3,199 As of 2016 Risk-free interest rate 1.14 % Expected volatility 104 % Expected term in years 5.3 Dividend yield - % |
Stockholders' Equity
Stockholders' Equity | 9 Months Ended |
Sep. 30, 2016 | |
Stockholders' Equity Note [Abstract] | |
Stockholders' Equity | 9. Stockholders’ Equity Stockholders’ Equity totaled $ 9.4 9.8 95,645,224 |
Stock-Based Compensation and Wa
Stock-Based Compensation and Warrants | 9 Months Ended |
Sep. 30, 2016 | |
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] | |
Stock-Based Compensation and Warrants | 10. Stock-Based Compensation and Warrants The Plan - In 2007, the Company adopted the First Amended 2007 Stock Incentive Plan, as amended (the “Plan”). The Plan provides for the grant of Incentive Stock Options, Nonqualified Stock Options, Restricted Stock Awards, Restricted Stock Unit Awards, Performance Awards and other stock-based awards, or any combination of the foregoing to the Company’s key employees, non-employee directors and consultants. Under the Plan, the exercise price is determined by the Board of Directors or the compensation committee of the Board of Directors, and for options intended to qualify as qualified incentive stock options, may not be less than the fair market value as determined by the closing stock price at the date of the grant. Each option and award shall vest and expire as determined by the Board of Directors or the compensation committee. Options expire no later than ten years from the date of grant. All grants provide for accelerated vesting if there is a change of control, as defined in the Plan. Stock-based compensation expense was $ 0.2 0.1 0.1 0.1 36,000 Stock-based compensation expense was $ 0.6 0.3 0.3 0.2 0.2 0.1 2016 2015 Risk-free interest rate 1.37 % 1.65 % Expected volatility 109 % 138 % Expected term in years 6.1 6.1 Dividend yield - % - % Weighted Average Exercise Options Price (in thousands) Outstanding at December 31, 2015 5,752 $ 1.05 Granted 1,300 2.55 Outstanding at September 30, 2016 7,052 1.33 Exercisable at September 30, 2016 5,420 $ 1.00 As of September 30, 2016, the aggregate intrinsic value of outstanding stock options was $ 2.4 2.0 As of September 30, 2016, unamortized stock-based compensation expense for all outstanding options was $ 2.1 3.1 W arrants - 10,000 0.90 |
Commitments and Contingencies
Commitments and Contingencies | 9 Months Ended |
Sep. 30, 2016 | |
Commitments and Contingencies Disclosure [Abstract] | |
Commitments and Contingencies | Commitments and Contingencies Technology License 0.1 Operating Leases 0.2 In April 2016, the Company entered into a three-year lease agreement for lab space located in Bellaire, Texas. The term of lease began on May 1, 2016 and terminates on April 30, 2019 and will require Bio-Path to pay $ 2,500 0.1 Drug Supplier Project Plan 0.1 0.1 0.9 0.1 0.2 . Service Agreement On September 30, 2016, the Company entered into a service agreement with a preclinical stage biotechnology company in connection with a development project involving our DNAbilize technology, pursuant to which we agreed to perform certain evaluation services in exchange for $ 50,000 |
Fair Value Measurements (Tables
Fair Value Measurements (Tables) | 9 Months Ended |
Sep. 30, 2016 | |
Fair Value Disclosures [Abstract] | |
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis | The following table summarizes the Company’s 2016 Warrants measured at fair value within the hierarchy on a recurring basis as of September 30, 2016: Fair Value Measurements at September 30, 2016 (in thousands) Level 1 Level 2 Level 3 Total Liabilities: Warrant liability $ - $ - $ 3,199 $ 3,199 |
Fair Value, Instruments Classified in Shareholders' Equity Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block] | The following table summarizes changes to the fair value of the Level 3 2016 Warrants for the nine months ended September 30, 2016: Fair Value of Warrant Liability (in thousands) Balance at December 31, 2015 $ - Issuance 4,619 Change in fair value (1,420) Balance at September 30, 2016 $ 3,199 |
Fair Value Measurements, Recurring and Nonrecurring, Valuation Techniques | The Company utilized the Binomial Lattice Model for estimating the fair value of the 2016 Warrants using the following assumptions as of September 30, 2016: As of 2016 Risk-free interest rate 1.14 % Expected volatility 104 % Expected term in years 5.3 Dividend yield - % |
Stock-Based Compensation and 18
Stock-Based Compensation and Warrants (Tables) | 9 Months Ended |
Sep. 30, 2016 | |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions | The Company utilized the Black-Scholes valuation model for estimating the fair value of the stock options granted, with 2016 2015 Risk-free interest rate 1.37 % 1.65 % Expected volatility 109 % 138 % Expected term in years 6.1 6.1 Dividend yield - % - % |
Schedule of Share-based Compensation, Stock Options, Activity | The following summary represents option activity under the Company’s stock-based compensation plan for the nine months ended September 30, 2016: Weighted Average Exercise Options Price (in thousands) Outstanding at December 31, 2015 5,752 $ 1.05 Granted 1,300 2.55 Outstanding at September 30, 2016 7,052 1.33 Exercisable at September 30, 2016 5,420 $ 1.00 |
Organization and Business - Add
Organization and Business - Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | ||||
Jun. 29, 2016 | Jun. 30, 2015 | Sep. 30, 2016 | Dec. 31, 2015 | Sep. 30, 2015 | Dec. 31, 2014 | |
Organization and Nature of Operations [Line Items] | ||||||
Cash | $ 11,299 | $ 8,854 | $ 9,855 | $ 13,859 | ||
Stock issued during period, shares, new issues | 5,882,352 | |||||
Stock issued during period, value, new issues | $ 10,000 | |||||
Proceeds from issuance initial public offering | 9,300 | |||||
Debt Issuance Costs, Net | $ 300 | |||||
Common Stock | ||||||
Organization and Nature of Operations [Line Items] | ||||||
Stock To Be Issued | 25,000,000 | |||||
Warrant | ||||||
Organization and Nature of Operations [Line Items] | ||||||
Stock issued during period, shares, new issues | 2,941,176 |
Prepaid Drug Product for Test20
Prepaid Drug Product for Testing - Additional Information (Detail) - USD ($) $ in Thousands | Sep. 30, 2016 | Dec. 31, 2015 |
Prepaid Expenses Disclosure [Line Items] | ||
Prepaid drug product for testing | $ 196 | $ 560 |
Other Current Assets - Addition
Other Current Assets - Additional Information (Detail) - USD ($) $ in Thousands | Sep. 30, 2016 | Dec. 31, 2015 |
Other Assets Current | $ 912 | $ 179 |
Prepaid Expenses [Member] | ||
Other Assets Current | $ 200 |
Accounts Payable - Additional I
Accounts Payable - Additional Information (Detail) - USD ($) $ in Millions | Sep. 30, 2016 | Dec. 31, 2015 |
Accounts Payable [Line Items] | ||
Accounts payable | $ 0.1 | $ 0.1 |
Accrued Expense - Additional In
Accrued Expense - Additional Information (Detail) - USD ($) $ in Thousands | Sep. 30, 2016 | Dec. 31, 2015 |
Accounts Payable and Accrued Liabilities [Line Items] | ||
Accrued expense | $ 748 | $ 883 |
Warrant Liability - Additional
Warrant Liability - Additional Information (Detail) - USD ($) $ in Millions | 9 Months Ended | |
Sep. 30, 2016 | Jul. 05, 2016 | |
Warrant Liability [Line Items] | ||
Derivative Liability, Fair Value, Gross Liability | $ 3.2 | $ 4.6 |
Increase (Decrease) in Derivative Liabilities | $ 1.4 | |
Healthcare Institutional Investors [Member] | ||
Warrant Liability [Line Items] | ||
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | 2,941,176 | |
H.C. Wainwright Co., LLC [Member] | ||
Warrant Liability [Line Items] | ||
Class of Warrant or Right, Number of Securities Called by Warrants or Rights | 250,000 |
Fair Value, Assets and Liabilit
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis (Detail) - USD ($) $ in Thousands | Sep. 30, 2016 | Dec. 31, 2015 |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Warrant liability | $ 3,199 | $ 0 |
Fair Value, Inputs, Level 1 [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Warrant liability | 0 | |
Fair Value, Inputs, Level 2 [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Warrant liability | 0 | |
Fair Value, Inputs, Level 3 [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Warrant liability | $ 3,199 |
Fair Value Of Warrant Liability
Fair Value Of Warrant Liability (Detail) $ in Thousands | 9 Months Ended |
Sep. 30, 2016USD ($) | |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | |
Balance at December 31, 2015 | $ 0 |
Issuance | 4,619 |
Change in fair value | (1,420) |
Balance at September 30, 2016 | $ 3,199 |
Fair Value Assumptions and Meth
Fair Value Assumptions and Methodology for Assets and Liabilities (Detail) | 9 Months Ended |
Sep. 30, 2016 | |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | |
Risk-free interest rate | 1.14% |
Expected volatility | 104.00% |
Expected term in years | 5 years 3 months 18 days |
Dividend yield | 0.00% |
Stockholders' Equity - Addition
Stockholders' Equity - Additional Information (Detail) - USD ($) $ in Thousands | Sep. 30, 2016 | Dec. 31, 2015 |
Shareholders Equity [Line Items] | ||
Common Stock, shares issued | 95,645,224 | 89,762,872 |
Common Stock, shares outstanding | 95,645,224 | 89,762,872 |
Stockholders Equity | $ 9,377 | $ 9,818 |
Weighted Average Assumptions (D
Weighted Average Assumptions (Detail) | 9 Months Ended | |
Sep. 30, 2016 | Sep. 30, 2015 | |
Share Based Compensation Plans [Line Items] | ||
Risk-free interest rate | 1.37% | 1.65% |
Expected volatility | 109.00% | 138.00% |
Expected term in years | 6 years 1 month 6 days | 6 years 1 month 6 days |
Dividend yield | 0.00% | 0.00% |
Option Activity Under Plan (Det
Option Activity Under Plan (Detail) shares in Thousands | 9 Months Ended |
Sep. 30, 2016$ / sharesshares | |
Share Based Compensation Plans [Line Items] | |
Outstanding | shares | 5,752 |
Granted | shares | 1,300 |
Outstanding | shares | 7,052 |
Exercisable | shares | 5,420 |
Weighted - Average Exercise Price, Outstanding | $ / shares | $ 1.05 |
Weighted - Average Exercise Price, Granted | $ / shares | 2.55 |
Weighted - Average Exercise Price, Outstanding | $ / shares | 1.33 |
Weighted - Average Exercise Price, Exercisable | $ / shares | $ 1 |
Stock-Based Compensation and 31
Stock-Based Compensation and Warrants - Additional Information (Detail) - USD ($) | 3 Months Ended | 9 Months Ended | 12 Months Ended | ||
Sep. 30, 2016 | Sep. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015 | Dec. 31, 2015 | |
Stock Based Compensation Plans [Line Items] | |||||
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options | $ 2,100,000 | $ 2,100,000 | |||
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value | 2,400,000 | $ 2,000,000 | |||
Stock-based compensation expense | $ 200,000 | $ 100,000 | $ 600,000 | $ 300,000 | |
Stock Compensation Plan [Member] | |||||
Stock Based Compensation Plans [Line Items] | |||||
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term | 3 years 1 month 6 days | ||||
Warrants | |||||
Stock Based Compensation Plans [Line Items] | |||||
Class of Warrant or Right, Outstanding | 10,000 | 10,000 | |||
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ 0.90 | $ 0.90 | |||
Research and Development Expense | |||||
Stock Based Compensation Plans [Line Items] | |||||
Stock-based compensation expense | $ 100,000 | $ 36,000 | $ 200,000 | 100,000 | |
General and Administrative Expense [Member] | |||||
Stock Based Compensation Plans [Line Items] | |||||
Stock-based compensation expense | $ 100,000 | $ 300,000 | $ 200,000 |
Commitments and Contingencies -
Commitments and Contingencies - Additional Information (Detail) - USD ($) | 1 Months Ended | 9 Months Ended | |
Apr. 30, 2016 | Sep. 30, 2016 | Dec. 31, 2015 | |
Product Liability Contingency [Line Items] | |||
Accounts payable and accrued liabilities | $ 100,000 | ||
Drug Product Testing Agreement Consideration To Be Paid In Stages | $ 100,000 | ||
Prepaid Expense, Current | 196,000 | $ 560,000 | |
Drug Supplier Commitments Development | 200,000 | ||
Development Project ,Service Evaluation Exchange Cost | 50,000 | ||
Lab Space [Member] | |||
Product Liability Contingency [Line Items] | |||
Operating Leases, Future Minimum Payments Due | 100,000 | ||
Operating Lease Monthly Rental Payments | $ 2,500 | ||
Office Space [Member] | |||
Product Liability Contingency [Line Items] | |||
Operating Leases, Future Minimum Payments Due | 200,000 | ||
Second Drug [Member] | |||
Product Liability Contingency [Line Items] | |||
Prepaid Expense, Current | 100,000 | ||
Final Drug [Member] | |||
Product Liability Contingency [Line Items] | |||
Drug Product Testing Agreement Consideration To Be Paid In Stages | 100,000 | ||
Drug Supplier Commitments Development | $ 900,000 |