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Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference in the Registration Statements onForm S-3(Nos. 333-225434,333-219304) andForm S-8(Nos. 333-141903,333-152824,333-173862,333-181117,333-187243,333-194477,333-202680,333-206128,333-212615,333-224503) of Madrigal Pharmaceuticals, Inc. of our report dated February 26, 2020 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in thisForm 10-K.
/s/ PricewaterhouseCoopers LLP
Philadelphia, Pennsylvania
February 26, 2020