Helicos BioSciences (HLCSQ) 10-K 2011 FY Annual report

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EXHIBIT 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

        We hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (File Nos. 333-156885, 333-162240 and 333-163011) and Form S-8 (File Nos. 333-166100, 333-144094, 333-149767, 333-158298 and 333-173226) of Helicos BioSciences Corporation of our report dated March 30, 2012 relating to the financial statements which appear in this Form 10-K.

/s/ PricewaterhouseCoopers LLP
Boston, Massachusetts
March 30, 2012

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EXHIBIT 23.1