Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We hereby consent to the incorporation by reference in this Amendment No. 1 to the Registration Statement on Form S-3 of Milestone Pharmaceuticals Inc. of our report dated March 29, 2021 relating to the consolidated financial statements, which appears in Milestone Pharmaceuticals Inc.'s Annual Report on Form 10- K for the year ended December 31, 2020.
We also consent to the reference to us under the heading "Experts" in this Amendment No. 1 to the Registration Statement on Form S-3.
Partnership of Chartered Professional Accountants
Montreal, Quebec,
Canada October 28, 2021
PricewaterhouseCoopers LLP/ s.r.l./ s.e.n.c.r.l.
1250 Rene-Levesque Boulevard West, Suite 2500, Montr eal, Quebec, Canada H3B
4Y1 T: +1514205 5000, F: +1514 8761502, www.pwc.com/ ca
"PwC" refers to PricewaterhouseCoopers LLP /s.r.1./ s.e.n.c.r.l., an Ontario limited liability partnership.
