January 14, 2021
VIA EDGAR SUBMISSION
Securities and Exchange Commission
Division of Corporation Finance
100 F Street, NE
Washington, DC 20549
Attention: Alan Campbell
| Re: | Syros Pharmaceuticals, Inc, |
Registration Statement on Form S-3
File No. 333-251941
Request for Acceleration
Ladies and Gentlemen:
Pursuant to Rule 461 under the Securities Act of 1933, as amended, Syros Pharmaceuticals, Inc. (the “Company”) hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-251941), so that it may become effective at 9:00 a.m., Eastern Time, on January 19, 2021, or as soon as practicable thereafter.
Very truly yours,
SYROS PHARMACEUTICALS, INC. | ||
| By: | /s/ Gerald E. Quirk | |
| Name: Gerald E. Quirk | ||
| Title: Chief Legal & Administrative Officer | ||
