August 4, 2022
VIA EDGAR SUBMISSION
Securities and Exchange Commission
Division of Corporation Finance
100 F Street, NE
Washington, DC 20549
Attention: Conlon Danberg
| Re: | Syros Pharmaceuticals, Inc. |
Registration Statement on Form S-4
File No. 333-266184
Request for Acceleration
Ladies and Gentlemen:
Pursuant to Rule 461 under the Securities Act of 1933, as amended, Syros Pharmaceuticals, Inc. hereby requests acceleration of the effective date of its Registration Statement on Form S-4 (File No. 333-266184), so that it may become effective at 4:00 p.m., Eastern Time, on August 8, 2022, or as soon as practicable thereafter.
| Very truly yours, | ||
| SYROS PHARMACEUTICALS, INC. | ||
| By: | /s/ Jason Haas | |
| Name: | Jason Haas | |
| Title: | Chief Financial Officer | |
