Exhibit 4.1
C0000000230 | M 104598 Number 00000000 Shares * * * * 0 * * * * * * * * * * * * * * 0 * * * * * * * * * * * * * * 0 * * * * * * * * * * * * * * 0 * * * * * * * * * * * * * * 0 * * * * * sophiris A BRITISH COLUMBIA COMPANY THIS CERTIFIES THAT **SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SO PHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIM EN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*B IO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q 10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.z ero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC. SPECIMEN zero****SPECIMEN83578Q10000000 000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****S PECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHI RIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN8 3578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO* INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q10000000000SOPHIRIS*BIO*INC.zero****SPECIMEN83578Q100 CUSIP 83578Q100 ISIN CA83578Q1000 IS THE REGISTERED HOLDER OF **083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero** **083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero** **083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero** **083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero** **083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC. * * * 0 * * * zero****083578Q10000000000SOPHIRIS*BIO*INC.zero** **083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero** **083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero** **083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero** **083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero** **083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero****083578Q10000000000SOPHIRIS*BIO*INC.zero** SEE REVERSE FOR CERTAIN DEFINITIONS FULLY PAID AND NON-ASSESSABLE COMMON SHARES WITHOUT PAR VALUE IN THE CAPITAL OF SOPHIRIS BIO INC. in the Authorized share structure of the above named Company subject to the Articles of the Company transferable on the Central Securities Register of the Company by the registered holder in person or by attorney duly authorized in writing upon surrender of this certificate properly endorsed. This certificate is not valid unless countersigned by the Transfer Agent and Registrar of the Company. IN WITNESS WHEREOF the Company has caused this certificate to be signed on its behalf by the facsimile signatures of its duly authorized officers, at Vancouver, British Columbia. President and Chief Executive Officer Dated: Feb 01, 2013 COUNTERSIGNED AND REGISTERED COMPUTERSHARE TRUST COMPANY, N.A. (GOLDEN CO) TRANSFER AGENT AND REGISTRAR OR COUNTERSIGNED AND REGISTERED COMPUTERSHARE TRUST COMPANY OF CANADA (VANCOUVER) (TORONTO) TRANSFER AGENT AND REGISTRAR Chief Financial Officer By _____________________________ Authorized Officer By ____________________________ Authorized Officer The shares represented by this certificate are transferable at the offices of Computershare Trust Company of Canada in Vancouver, BC; Toronto, ON and Computershare Trust Company, N.A. in Golden, CO.
VOIDThe following abbreviations shall be construed as though the words set forth below opposite each abbreviation were written out in full where such abbreviation appears: TEN COM - as tenants in common (Name) CUST (Name) UNIF - (Name) as Custodian for (Name) under the TEN ENT - as tenants by the entireties GIFT MIN ACT (State) (State) Uniform Gifts to Minors Act JT TEN - as joint tenants with rights of survivorship and not as tenants in common Additional abbreviations may also be used though not in the above list. For value received the undersigned hereby sells, assigns and transfers unto Insert name and address of transferee shares represented by this certificate and does hereby irrevocably constitute and appoint the attorney of the undersigned to transfer the said shares on the books of the Company with full power of substitution in the premises. DATED: Signature of Shareholder Signature of Guarantor Signature Guarantee: The signature on this assignment must correspond with the name as written upon the face of the certificate(s), in every particular, without alteration or enlargement, or any change whatsoever and must be guaranteed by a major Canadian Schedule I chartered bank or a member of an acceptable Medallion Signature Guarantee Program (STAMP, SEMP, MSP). The Guarantor must affix a stamp bearing the actual words “Signature Guaranteed”. In the USA, signature guarantees must be done by members of a “Medallion Signature Guarantee Program” only. Signature guarantees are not accepted from Treasury Branches, Credit Unions or Caisses Populaires unless they are members of the Stamp Medallion Program. SECURITY INSTRUCTIONS - INSTRUCTIONS DE SECURITE THIS IS WATERMARKED PAPER, DO NOT ACCEP1 WIIMOUT NOTING WAIEHMARK HOLD TO LIGHT TO VERIFY WATERMARK PAPII R IIIIGHANI , Nl PAS ACCEPTER SANS VERIFIER IA PRESENCE DU FILIGRANE, POUR CE FAIRE, PLACER A LA LUMIERE. EN_COMP_V2_Q1
