Certification of Chief Executive Officer
I, Matthew Kapusta, certify that:
1. I have reviewed this Amendment No. 1 to Form 10-K amending the Annual Report on Form 10-K for the fiscal year ended December 31, 2018 of uniQure N.V.; and
2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report.
| By: | /s/ MATTHEW KAPUSTA |
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| Matthew Kapusta |
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| Chief Executive Officer |
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| April 29, 2019 |