Blueprint Medicines (BPMC) Form 4 Blueprint Medicines / Debra Durso-Bumpus ownership change

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:	3235-0287
Estimated average burden
hours per response:	0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

Durso-Bumpus Debra

(Last) (First) (Middle)

C/O BLUEPRINT MEDICINES CORPORATION

45 SIDNEY STREET

(Street)

CAMBRIDGE MA 02139

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Blueprint Medicines Corp [ BPMC ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	10% Owner
X	Officer (give title below)	Other (specify below)
CHIEF PEOPLE OFFICER

3. Date of Earliest Transaction (Month/Day/Year)
06/21/2024

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	06/21/2024		M(1)		13,741	A	$18	71,056	D
Common Stock	06/21/2024		M(1)		7,041	A	$18	78,097	D
Common Stock	06/21/2024		M(1)		24,200	A	$36.05	102,297	D
Common Stock	06/21/2024		M(1)		15,500	A	$54.13	117,797	D
Common Stock	06/21/2024		S(1)		1,567	D	$105.82(2)	116,230	D
Common Stock	06/21/2024		S(1)		18,752	D	$104.98(3)	97,478	D
Common Stock	06/21/2024		S(1)		40,353	D	$104.14(4)	57,125	D
Common Stock	06/21/2024		S(1)		13,062	D	$103.05(5)	44,063	D
Common Stock	06/21/2024		S(1)		300	D	$102.44(6)	43,763	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$18	06/21/2024		M(1)			13,471	(7)	04/27/2025	Common Stock	13,471	$0	0	D
Stock Option (Right to Buy)	$18	06/21/2024		M(1)			7,041	(7)	04/27/2025	Common Stock	7,041	$0	0	D
Stock Option (Right to Buy)	$36.05	06/21/2024		M(1)			24,200	(8)	02/16/2027	Common Stock	24,200	$0	0	D
Stock Option (Right to Buy)	$54.13	06/21/2024		M(1)			15,500	(9)	03/01/2030	Common Stock	15,500	$0	13,000	D

Explanation of Responses:

1. Effected pursuant to a trading plan adopted on March 13, 2024 pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended.

2. The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $105.53 to $106.51 per share. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnotes (2) through (6) in this form 4.

3. The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $104.52 to $105.51 per share.

4. The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $103.53 to $104.51 per share.

5. The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $102.51 to $103.51 per share.

6. The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $102.44 to $102.45 per share.

7. This option was granted on April 27, 2015 and is fully vested as of the transaction date.

8. This option was granted on February 16, 2017 and is fully vested as of the transaction date.

9. This option was granted on March 1, 2020 and is fully vested as of the transaction date.

	/s/ Melissa Masse	06/25/2024
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.