Summit Therapeutics (SMMT) 10-Q 2024 Q3 Quarterly report

EXHIBIT 32.1

CERTIFICATION OFPRINCIPAL EXECUTIVE OFFICERS AND PRINCIPAL FINANCIAL OFFICER PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of Summit Therapeutics Inc. (the “Company”) for the quarter ended September 30, 2024, as filed with the U.S. Securities and Exchange Commission on the date hereof (the “Report”), each of the undersigned officers does hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

1.The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

2.The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: October 30, 2024
By:	/s/ Robert W. Duggan
	Name:	Robert W. Duggan
	Title:	Chairman and Co-Chief Executive Officer
		(Principal Executive Officer)
Date: October 30, 2024
By:	/s/ Mahkam Zanganeh
	Name:	Dr. Mahkam Zanganeh
	Title:	Executive Director, Co-Chief Executive Officer, and President
		(Principal Executive Officer)
Date: October 30, 2024
By:	/s/ Manmeet Soni
	Name:	Manmeet Soni
	Title:	Chief Operating Officer and Chief Financial Officer
		(Principal Financial Officer)