Cover
| Cover | Aug. 14, 2023 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | Aug. 14, 2023 |
| Entity File Number | 001-37526 |
| Entity Registrant Name | ZYNERBA PHARMACEUTICALS, INC. |
| Entity Central Index Key | 0001621443 |
| Entity Tax Identification Number | 26-0389433 |
| Entity Incorporation, State or Country Code | DE |
| Entity Address, Address Line One | 80 W. Lancaster Avenue |
| Entity Address, Address Line Two | Suite 300 |
| Entity Address, City or Town | Devon |
| Entity Address, State or Province | PA |
| Entity Address, Postal Zip Code | 19333 |
| City Area Code | 484 |
| Local Phone Number | 581-7505 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common Stock, $0.001 par value per share |
| Trading Symbol | ZYNE |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | false |