VOTE BY INTERNET Before The Meeting - Go to www.proxyvote.com AXOVANT GENE THERAPIES LTD. Use the Internet to transmit your voting instructions and for electronic delivery of SUITE 1, 3RD FLOOR information up until 11:59 p.m. Eastern Time on September 23, 2020. Have your 11-12 ST. JAMES SQUARE proxy card in hand when you access the web site and follow the instructions to LONDON SW1Y 4LB obtain your records and to create an electronic voting instruction form. UNITED KINGDOM During The Meeting - Go to www.virtualshareholdermeeting.com/AXGT2020 You may attend the meeting via the Internet and vote during the meeting. Have the information that is printed in the box marked by the arrow available and follow the instructions. VOTE BY PHONE - 1-800-690-6903 Use any touch-tone telephone to transmit your voting instructions up until 11:59 p.m. Eastern Time on September 23, 2020. Have your proxy card in hand when you call and then follow the instructions. VOTE BY MAIL Mark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717. TO VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS FOLLOWS: D21839-P43131 KEEP THIS PORTION FOR YOUR RECORDS THIS PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED. DETACH AND RETURN THIS PORTION ONLY AXOVANT GENE THERAPIES LTD. The Board of Directors recommends you vote FOR the following: 1. Election of Directors Nominees: For Against Abstain 1a. Frank Torti, M.D. ! ! ! 1b. Atul Pande, M.D. ! ! ! 1c. Pavan Cheruvu, M.D. ! ! ! 1d. Berndt Modig ! ! ! 1e. Senthil Sundaram ! ! ! 1f. Eric Venker, M.D., Pharm.D. ! ! ! The Board of Directors recommends you vote FOR the following proposal: For Against Abstain 2. To ratify the selection by the Audit Committee of the Board of Directors of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending March 31, 2021, to appoint Ernst & Young LLP as our auditor for statutory purposes under the Bermuda Companies Act 1981, ! ! ! as amended, for our fiscal year ending March 31, 2021 and to authorize the Board of Directors, through the Audit Committee, to set the remuneration for Ernst & Young LLP as our auditor for our fiscal year ending March 31, 2021. NOTE: The proxies are authorized to vote, in their discretion, upon such other business as may properly come before the meeting or any adjournment thereof. Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Joint owners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name by authorized officer. Signature [PLEASE SIGN WITHIN BOX] Date Signature (Joint Owners) Date
D21840-P43131 AXOVANT GENE THERAPIES LTD. Annual General Meeting of Shareholders September 24, 2020 10:00 AM, Eastern Time This proxy is solicited by the Board of Directors The shareholder(s) hereby appoint(s) Pavan Cheruvu, M.D. and David Nassif, or any of them, as proxies, each with the power to appoint their substitute, and hereby authorize(s) them to represent and to vote, as designated on the reverse side of this ballot, all of the Common Shares of AXOVANT GENE THERAPIES LTD. that the shareholder(s) is/are entitled to vote at the Annual General Meeting of Shareholders to be held online at 10:00 AM, Eastern time, on September 24, 2020, at www.virtualshareholdermeeting.com/AXGT2020, and any adjournment or postponement thereof. This proxy, when properly executed, will be voted in the manner directed herein. If no such direction is made, this proxy will be voted in accordance with the Board of Directors' recommendations. Continued and to be signed on reverse side