vTv Therapeutics (VTVT) 10-K 2021 FY Annual report

Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the following Registration Statements:

(1) Registration Statement (Form S-8 No. 333-206335) pertaining to the vTv Therapeutics Inc. 2015 Omnibus Equity Incentive Plan;

(2) Registration Statement (Form S-3 No. 333-232571) of vTv Therapeutics Inc.;

(3) Registration Statement (Form S-8 No. 333-240304) of vTv Therapeutics Inc.;

(4) Registration Statement (Form S-1 No. 333-250934) of vTv Therapeutics Inc.;

(5) Registration Statement (Form S-3 No. 333-254445) of vTv Therapeutics Inc.; and

(6) Registration Statement (Form S-3 No. 333-256755) of vTv Therapeutics Inc.

of our report dated March 29, 2022 with respect to the consolidated financial statements of vTv Therapeutics Inc. included in this Annual Report (Form 10-K) for the year ended December 31, 2021.

/s/ Ernst & Young LLP

Raleigh, North Carolina

March 29, 2022