Exhibit (e)
Rule 466 Certification
The depositary, Citibank, N.A., represents and certifies the following:
| (i) | That it had previously filed a registration statement on Form F-6 (Registration No. 333-217353) with respect to Verona Pharma plc, which the U.S. Securities and Exchange Commission declared effective, with terms of deposit identical to the terms of deposit of this Form F-6 Registration Statement; and |
| (ii) | That its ability to designate the date and time of effectiveness under Rule 466 has not been suspended. |
CITIBANK, N.A., as Depositary | ||
| By: | /s/ Joseph Connor | |
Name: Joseph Connor | ||
Title: Attorney-in-Fact | ||
