CRISPR Therapeutics (CRSP) Form 3 CRISPR Therapeutics / PHARMACEUTICALS INC / MA VERTEX ownership change

SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

Vertex Pharmaceuticals (Europe) Ltd

(Last) (First) (Middle)

2 KINGDOM ST., 9TH FLOOR

(Street)

LONDON X0 W2 6BD

(City) (State) (Zip)

2. Date of Event Requiring Statement (Month/Day/Year)
12/20/2018

3. Issuer Name and Ticker or Trading Symbol
CRISPR Therapeutics AG [ CRSP ]

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

Director	X	10% Owner
Officer (give title below)		Other (specify below)

5. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

	Form filed by One Reporting Person
X	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Shares	5,250,000(1)	D(1)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person^*

Vertex Pharmaceuticals (Europe) Ltd

(Last) (First) (Middle)

2 KINGDOM ST., 9TH FLOOR

(Street)

LONDON X0 W2 6BD

(City) (State) (Zip)

1. Name and Address of Reporting Person^*

VERTEX PHARMACEUTICALS INC / MA

(Last) (First) (Middle)

50 NORTHERN AVENUE

(Street)

BOSTON MA 02210

(City) (State) (Zip)

Explanation of Responses:

1. Shares are directly held by Vertex Pharmaceuticals (Europe) Limited ("Vertex Europe"). Vertex Europe is an indirect wholly owned subsidiary of Vertex Pharmaceuticals Inc. Vertex Pharmaceuticals Inc. may be deemed to beneficially own the shares owned directly by Vertex Europe.

Remarks:

	/s/ Ian F. Smith, on behalf of Vertex Pharmaceuticals (Europe) Limited	12/21/2018
	/s/ Ian F. Smith, on behalf of Vertex Pharmaceuticals Inc.	12/21/2018
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
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