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Exhibit 23.1
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Consent of Independent Registered Public Accounting Firm
Spruce Biosciences, Inc.
Daly City, California
We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (No. 333-249431) and (No. 333-254593) of Spruce Biosciences, Inc. of our report dated March 14, 2022, relating to the financial statements which appear in this Form 10K.
/s/ BDO USA, LLP
San Jose, California
March 14, 2022