Spruce Biosciences (SPRB) SC 13G SPRUCE BIOSCIENCES / Omega Fund VI ownership change

CUSIP No. 85209E109 13G Exhibit 99.1

AGREEMENT

Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of Common Stock of Spruce Biosciences, Inc.

Dated:		February 12, 2021
OMEGA FUND VI, L.P.
BY:		Omega Fund VI GP, L.P.
ITS:		GENERAL PARTNER
BY:		Omega Fund VI GP Manager, Ltd.
ITS:		GENERAL PARTNER
By:	/s/ * Deirdre A. Cunnane, as Attorney-in-Fact
		Director
OMEGA FUND VI GP, L.P.
BY:		Omega Fund VI GP Manager, Ltd.
ITS:		GENERAL PARTNER
By:	/s/ * Deirdre A. Cunnane, as Attorney-in-Fact
		Director
OMEGA FUND VI GP MANAGER, LTD.
By:	/s/ * Deirdre A. Cunnane, as Attorney-in-Fact
		Director
/s/ * Deirdre A. Cunnane, as Attorney-in-Fact
Claudio Nessi
/s/ * Deirdre A. Cunnane, as Attorney-in-Fact
Otello Stampacchia
/s/ * Deirdre A. Cunnane, as Attorney-in-Fact
Anne-Mari Paster