Cover Page
Cover Page - shares | 9 Months Ended | |
Sep. 30, 2021 | Oct. 31, 2021 | |
Cover [Abstract] | ||
Document Type | 10-Q | |
Amendment Flag | false | |
Document Quarterly Report | true | |
Document Transition Report | false | |
Document Period End Date | Sep. 30, 2021 | |
Document Fiscal Year Focus | 2021 | |
Document Fiscal Period Focus | Q3 | |
Trading Symbol | MGTA | |
Entity Registrant Name | Magenta Therapeutics, Inc. | |
Entity Central Index Key | 0001690585 | |
Current Fiscal Year End Date | --12-31 | |
Entity Current Reporting Status | Yes | |
Entity Filer Category | Non-accelerated Filer | |
Entity Ex Transition Period | false | |
Entity Emerging Growth Company | true | |
Entity Small Business | true | |
Entity Shell Company | false | |
Entity Common Stock, Shares Outstanding | 58,777,271 | |
Entity Interactive Data Current | Yes | |
Title of 12(b) Security | Common Stock | |
Security Exchange Name | NASDAQ | |
Entity Incorporation, State or Country Code | DE | |
Entity Address, Address Line One | 100 Technology Square | |
Entity Address, City or Town | Cambridge | |
Entity Address, Postal Zip Code | 02139 | |
Entity Address, State or Province | MA | |
City Area Code | (857 | |
Entity File Number | 001-38541 | |
Entity Tax Identification Number | 81-0724163 | |
Local Phone Number | 242-0170 |
Consolidated Balance Sheets
Consolidated Balance Sheets - USD ($) $ in Thousands | Sep. 30, 2021 | Dec. 31, 2020 |
Current assets: | ||
Cash and cash equivalents | $ 157,539 | $ 58,152 |
Marketable securities | 35,077 | 90,683 |
Prepaid expenses and other current assets | 3,859 | 2,692 |
Total current assets | 196,475 | 151,527 |
Restricted cash | 1,780 | 1,780 |
Property and equipment, net | 7,981 | 8,312 |
Total assets | 206,236 | 161,619 |
Current liabilities: | ||
Accounts payable | 1,886 | 3,760 |
Accrued expenses and other current liabilities | 8,261 | 7,670 |
Total current liabilities | 10,147 | 11,430 |
Deferred rent | 6,401 | 6,283 |
Total liabilities | 16,548 | 17,713 |
Commitments and contingencies (Note 6) | ||
Stockholders' Equity: | ||
Preferred stock, $0.001 par value; 10,000,000 shares authorized; no shares issued or outstanding | ||
Common stock, $0.001 par value; 150,000,000 shares authorized; 58,777,271 shares issued and outstanding as of September 30, 2021 and 48,541,601 shares issued and 48,533,135 shares outstanding as of December 31, 2020 | 59 | 49 |
Additional paid-in capital | 495,903 | 398,311 |
Accumulated other comprehensive income (loss) | 1 | (23) |
Accumulated deficit | (306,275) | (254,431) |
Total stockholders' equity | 189,688 | 143,906 |
Total liabilities and stockholders' equity | $ 206,236 | $ 161,619 |
Consolidated Balance Sheets (Pa
Consolidated Balance Sheets (Parenthetical) - $ / shares | Sep. 30, 2021 | Dec. 31, 2020 |
Preferred stock, par value | $ 0.001 | $ 0.001 |
Preferred stock, Shares authorized | 10,000,000 | 10,000,000 |
Preferred stock, Shares issued | 0 | 0 |
Preferred stock, Shares outstanding | 0 | 0 |
Common stock, Par value | $ 0.001 | $ 0.001 |
Common stock, shares authorized | 150,000,000 | 150,000,000 |
Common stock, Shares issued | 58,777,271 | 48,541,601 |
Common stock, Shares outstanding | 58,777,271 | 48,533,135 |
Consolidated Statements of Oper
Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | |
Operating expenses: | ||||
Research and development | $ 10,795 | $ 11,786 | $ 33,652 | $ 38,359 |
General and administrative | 7,450 | 6,595 | 20,900 | 21,278 |
Total operating expenses | 18,245 | 18,381 | 54,552 | 59,637 |
Loss from operations | (18,245) | (18,381) | (54,552) | (59,637) |
Interest and other income, net | 818 | 703 | 2,708 | 2,869 |
Net loss | $ (17,427) | $ (17,678) | $ (51,844) | $ (56,768) |
Net loss per share, basic and diluted | $ (0.30) | $ (0.37) | $ (0.97) | $ (1.34) |
Weighted average common shares outstanding, basic and diluted | 58,583,476 | 48,255,353 | 53,655,314 | 42,431,874 |
Comprehensive loss: | ||||
Net loss | $ (17,427) | $ (17,678) | $ (51,844) | $ (56,768) |
Other comprehensive income (loss): | ||||
Unrealized gains (losses) on marketable securities | (1) | (114) | 24 | 31 |
Total other comprehensive income (loss) | (1) | (114) | 24 | 31 |
Total comprehensive loss | $ (17,428) | $ (17,792) | $ (51,820) | $ (56,737) |
Consolidated Statements of Stoc
Consolidated Statements of Stockholders' Equity (Deficit) - USD ($) $ in Thousands | Total | Private Placement [Member] | Common Stock [Member] | Common Stock [Member]Private Placement [Member] | Additional Paid-in Capital [Member] | Additional Paid-in Capital [Member]Private Placement [Member] | Accumulated Other Comprehensive Income (Loss) [Member] | Accumulated Deficit [Member] |
Beginning balance at Dec. 31, 2019 | $ 141,193 | $ 39 | $ 320,641 | $ 8 | $ (179,495) | |||
Beginning balance, shares at Dec. 31, 2019 | 39,260,532 | |||||||
Issuance of common stock upon public offering net of underwriting discounts, commissions and offering costs | 64,563 | $ 9 | 64,554 | |||||
Issuance of common stock upon public offering net of underwriting discounts, commissions and offering costs , shares | 8,625,000 | |||||||
Vesting of restricted stock, shares | 162,195 | |||||||
Issuance of common stock upon exercise of stock options | 1,895 | 1,895 | ||||||
Issuance of common stock upon exercise of stock options, shares | 240,089 | |||||||
Issuance of common stock under Employee Stock Purchase Plan, shares | 5,653 | |||||||
Issuance of common stock under Employee Stock Purchase Plan | 42 | 42 | ||||||
Stock-based compensation expense | 7,610 | 7,610 | ||||||
Unrealized gains on marketable securities | 31 | 31 | ||||||
Net loss | (56,768) | (56,768) | ||||||
Ending balance at Sep. 30, 2020 | 158,566 | $ 48 | 394,742 | 39 | (236,263) | |||
Ending balance, shares at Sep. 30, 2020 | 48,293,469 | |||||||
Beginning balance at Dec. 31, 2019 | 141,193 | $ 39 | 320,641 | 8 | (179,495) | |||
Beginning balance, shares at Dec. 31, 2019 | 39,260,532 | |||||||
Net loss | (74,900) | |||||||
Ending balance at Dec. 31, 2020 | 143,906 | $ 49 | 398,311 | (23) | (254,431) | |||
Ending balance, shares at Dec. 31, 2020 | 48,533,135 | |||||||
Beginning balance at Jun. 30, 2020 | 173,914 | $ 48 | 392,298 | 153 | (218,585) | |||
Beginning balance, shares at Jun. 30, 2020 | 48,241,212 | |||||||
Vesting of restricted stock, shares | 36,522 | |||||||
Issuance of common stock upon exercise of stock options | 78 | 78 | ||||||
Issuance of common stock upon exercise of stock options, shares | 15,735 | |||||||
Stock-based compensation expense | 2,366 | 2,366 | ||||||
Unrealized gains on marketable securities | (114) | (114) | ||||||
Net loss | (17,678) | (17,678) | ||||||
Ending balance at Sep. 30, 2020 | 158,566 | $ 48 | 394,742 | 39 | (236,263) | |||
Ending balance, shares at Sep. 30, 2020 | 48,293,469 | |||||||
Beginning balance at Dec. 31, 2020 | 143,906 | $ 49 | 398,311 | (23) | (254,431) | |||
Beginning balance, shares at Dec. 31, 2020 | 48,533,135 | |||||||
Issuance of common stock upon public offering net of underwriting discounts, commissions and offering costs | $ 86,097 | $ 10 | $ 86,087 | |||||
Issuance of common stock upon public offering net of underwriting discounts, commissions and offering costs , shares | 9,599,998 | |||||||
Vesting of restricted stock, shares | 218,464 | |||||||
Issuance of common stock upon exercise of stock options | 3,294 | 3,294 | ||||||
Issuance of common stock upon exercise of stock options, shares | 411,685 | |||||||
Issuance of common stock under Employee Stock Purchase Plan, shares | 13,989 | |||||||
Issuance of common stock under Employee Stock Purchase Plan | 86 | 86 | ||||||
Stock-based compensation expense | 8,125 | 8,125 | ||||||
Unrealized gains on marketable securities | 24 | 24 | ||||||
Net loss | (51,844) | (51,844) | ||||||
Ending balance at Sep. 30, 2021 | 189,688 | $ 59 | 495,903 | 1 | (306,275) | |||
Ending balance, shares at Sep. 30, 2021 | 58,777,271 | |||||||
Beginning balance at Jun. 30, 2021 | 202,892 | $ 59 | 491,679 | 2 | (288,848) | |||
Beginning balance, shares at Jun. 30, 2021 | 58,508,735 | |||||||
Vesting of restricted stock, shares | 209,998 | |||||||
Issuance of common stock upon exercise of stock options | 425 | 425 | ||||||
Issuance of common stock upon exercise of stock options, shares | 58,538 | |||||||
Stock-based compensation expense | 3,799 | 3,799 | ||||||
Unrealized gains on marketable securities | (1) | (1) | ||||||
Net loss | (17,427) | (17,427) | ||||||
Ending balance at Sep. 30, 2021 | $ 189,688 | $ 59 | $ 495,903 | $ 1 | $ (306,275) | |||
Ending balance, shares at Sep. 30, 2021 | 58,777,271 |
Consolidated Statements of Cash
Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended | |
Sep. 30, 2021 | Sep. 30, 2020 | |
Cash flows from operating activities: | ||
Net loss | $ (51,844) | $ (56,768) |
Adjustments to reconcile net loss to net cash used in operating activities: | ||
Stock-based compensation expense | 8,125 | 7,610 |
Depreciation and amortization expense | 1,485 | 1,483 |
Loss on disposal of property and equipment | 95 | 1 |
Net amortization of premiums on marketable securities | 630 | 111 |
Changes in operating assets and liabilities: | ||
Prepaid expenses and other current assets | (1,167) | 1,579 |
Accounts payable | (1,874) | (423) |
Accrued expenses and other current liabilities | 591 | (3,888) |
Deferred rent | 118 | 5 |
Net cash used in operating activities | (43,841) | (50,290) |
Cash flows from investing activities: | ||
Purchases of property and equipment | (1,249) | (187) |
Purchases of marketable securities | (4,974) | |
Maturities of marketable securities | 55,000 | 65,500 |
Net cash provided by investing activities | 53,751 | 60,339 |
Cash flows from financing activities: | ||
Proceeds from private investment | 86,400 | |
Proceeds from public offerings, net of underwriting discounts and commissions | 64,860 | |
Payments of offering costs | (303) | (237) |
Proceeds from exercise of common stock options | 3,294 | 1,895 |
Proceeds from issuance of common stock under Employee Stock Purchase Plan | 86 | 42 |
Net cash provided by financing activities | 89,477 | 66,560 |
Net increase in cash, cash equivalents and restricted cash | 99,387 | 76,609 |
Cash, cash equivalents and restricted cash at beginning of period | 59,932 | 66,851 |
Cash, cash equivalents and restricted cash at end of period | $ 159,319 | 143,460 |
Supplemental disclosure of non-cash investing and financing activities: | ||
Offering costs included in accounts payable and accrued expenses | $ 60 |
Nature of the Business and Basi
Nature of the Business and Basis of Presentation | 9 Months Ended |
Sep. 30, 2021 | |
Nature of the Business and Basis of Presentation | 1. Nature of the Business and Basis of Presentation Magenta Therapeutics, Inc. (the “Company”) is a clinical-stage biotechnology company developing novel medicines designed June The Company is subject to risks and uncertainties common to early-stage companies in the biotechnology industry, including, but not limited to, development by competitors of new technological innovations, dependence on key personnel, protection of proprietary technology, compliance with government regulations, the continuing impact of the novel coronavirus (“COVID-19”) In May 2021, the Company issued and sold 9,599,998 shares of its common stock in a private placement at a purchase price of $9.00 per share, resulting in net proceeds of $86.1 million, after deducting offering expenses. In connection with the private placement, the Company filed a resale registration statement with the Securities and Exchange Commission (the “SEC”) in June 2021 to register the resale of these shares by the purchasers in the private placement. In June 2020, the Company issued and sold 8,625,000 shares of its common stock, including the underwriters’ exercise in full of their option to purchase additional shares of common stock, in a follow-on The Company has a shelf registration statement on Form S-3 “at-the-market” The Company has incurred recurring losses since inception, including net losses of $51.8 million and $74.9 million for the nine months ended September 30, 2021 and the year ended December 31, 2020, respectively. As of September 30, 2021, the Company had an accumulated deficit of $306.3 million. The Company expects to continue to generate operating losses for the foreseeable future. The Company expects that its cash, cash equivalents and marketable securities will be sufficient to fund its operating expenses and capital expenditure requirements through at least 12 months from the issuance date of these consolidated financial statements. The future viability of the Company beyond that point is dependent on its ability to raise additional capital to fund its operations. The Company expects its expenses to increase substantially in connection with ongoing activities, particularly as the Company advances its preclinical activities and clinical trials for its product candidates in development. Accordingly, the Company will need to obtain substantial additional funding in connection with continuing operations. If the Company is unable to raise capital when needed, or on attractive terms, it could be forced to delay, reduce or eliminate its research or drug development programs or any future commercialization efforts. Although management continues to pursue these plans, there is no assurance that the Company will be successful in obtaining sufficient funding on terms acceptable to the Company to fund continuing operations, if at all. The consolidated financial statements include the accounts of the Company and its wholly owned subsidiary. All intercompany balances and transactions have been eliminated. The consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”). |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 9 Months Ended |
Sep. 30, 2021 | |
Summary of Significant Accounting Policies | 2. Summary of Significant Accounting Policies Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting periods. Significant estimates and assumptions reflected in these financial statements include, but are not limited to, the accrual for research and development expenses and the valuation of stock-based awards. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates. Unaudited Interim Financial Information The consolidated balance sheet at December 31, 2020 was derived from audited financial statements but does not include all disclosures required by GAAP. The accompanying unaudited consolidated financial statements as of September 30, 2021 and for the three and nine months ended September 30, 2021 and 2020 have been prepared by the Company pursuant to the rules and regulations of the SEC for interim financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to such rules and regulations. The Company believes, however, that the disclosures are adequate to make the information presented not misleading. These consolidated financial statements should be read in conjunction with the Company’s audited financial statements for the year ended December 31, 2020 included in the Company’s Annual Report on Form 10-K, Fair Value Measurements Certain assets and liabilities are carried at fair value under GAAP. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy, of which the first two are considered observable and the last is considered unobservable: • Level 1—Quoted prices in active markets for identical assets or liabilities. • Level 2—Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable market data. • Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques. The Company’s cash equivalents and marketable securities are carried at fair value, determined according to the fair value hierarchy described above (see Note 3). The carrying values of the Company’s accounts payable and accrued expenses approximate their fair values due to the short-term nature of these assets and liabilities. Income Taxes The Company accounts for income taxes using the asset and liability method, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been recognized in the consolidated financial statements or in the Company’s tax returns. Deferred taxes are determined based on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect in the years in which the differences are expected to reverse. Changes in deferred tax assets and liabilities are recorded in the provision for income taxes. The Company assesses the likelihood that its deferred tax assets will be recovered from future taxable income and, to the extent it believes, based upon the weight of available evidence, that it is more likely than not that all or a portion of deferred tax assets will not be realized, a valuation allowance is established through a charge to income tax expense. Potential for recovery of deferred tax assets is evaluated by estimating the future taxable profits expected and considering prudent and feasible tax planning strategies. The Company accounts for uncertainty in income taxes recognized in its consolidated financial statements by applying a two-step more-likely-than-not Comprehensive Loss Comprehensive loss includes net loss as well as other changes in stockholders’ equity that result from transactions and economic events other than those with stockholders. For the three and nine months ended September 30, 2021 and 2020, the Company’s only element of other comprehensive income (loss) was unrealized gains (losses) on marketable securities. Net Loss per Share Basic net income (loss) per share is computed by dividing the net income (loss) by the weighted average number of shares of common stock outstanding for the period. Diluted net income (loss) per share is computed by dividing net income (loss) by the weighted average number of common shares outstanding for the period, including potential dilutive common shares assuming the dilutive effect of outstanding stock options. For periods in which the Company has reported net losses, diluted net loss per common share is the same as basic net loss per common share, since dilutive common shares are not assumed to have been issued if their affect is anti-dilutive. The Company reported a net loss for the three and nine months ended September 30, 2021 and 2020. The following potential dilutive securities, presented based on amounts outstanding at each period end, have been excluded from the calculation of diluted net loss per share because including them would have had an anti-dilutive impact: As of September 30, 2021 2020 Stock options to purchase common stock 6,091,220 5,782,911 Unvested restricted common stock and units 497,418 251,723 Shares of common stock issuable under Employee Stock Purchase Plan 8,843 8,213 6,597,481 6,042,847 Recently Issued Accounting Pronouncements In February 2016, the FASB issued ASU No. 2016-02, Leases 2016-02”). 2016-02 right-of-use No. 2020-05, 2016-02 2018-11, Leases (Topic 842) Targeted Improvements 2016-02 right-of-use In June 2016, the FASB issued ASU No. 2016-13, Financial Instruments – Credit Losses (Topic 326) No. 2019-10, |
Fair Value of Financial Assets
Fair Value of Financial Assets | 9 Months Ended |
Sep. 30, 2021 | |
Fair Value of Financial Assets | 3. Fair Value of Financial Assets As of September 30, 2021, marketable securities by security type consisted of (in thousands): Gross Gross Estimated Amortized Unrealized Unrealized Fair Cost Gains Losses Value U.S. treasury notes (due within one year) $ 35,076 $ 1 $ — $ 35,077 Total $ 35,076 $ 1 $ — $ 35,077 As of December 31, 2020, marketable securities by security type consisted of (in thousands): Gross Gross Estimated Amortized Unrealized Unrealized Fair Cost Gains Losses Value U.S. treasury notes (due within one year) $ 90,706 $ — $ (23 ) $ 90,683 Total $ 90,706 $ — $ (23 ) $ 90,683 The following tables present information about the Company’s financial assets measured at fair value on a recurring basis and indicate the level of the fair value hierarchy utilized to determine such fair values (in thousands): Fair Value Measurements at September 30, 2021 Using: Level 1 Level 2 Level 3 Total Cash equivalents: Money market funds $ 157,781 $ — $ — $ 157,781 Marketable securities: U.S. treasury notes — 35,077 — 35,077 Total $ 157,781 $ 35,077 $ — $ 192,858 Fair Value Measurements at December 31, 2020 Using: Level 1 Level 2 Level 3 Total Cash equivalents: Money market funds $ 43,182 $ — $ — $ 43,182 U.S. treasury notes — 14,999 — 14,999 Marketable securities: U.S. treasury notes — 90,683 — 90,683 Total $ 43,182 $ 105,682 $ — $ 148,864 |
Accrued Expenses and Other Curr
Accrued Expenses and Other Current Liabilities | 9 Months Ended |
Sep. 30, 2021 | |
Accrued Expenses and Other Current Liabilities | 4. Accrued Expenses and Other Current Liabilities Accrued expenses and other current liabilities consisted of the following (in thousands): September 30, 2021 December 31, 2020 Accrued external research and development expenses $ 3,294 $ 2,662 Accrued payroll and related expenses 2,983 3,107 Accrued professional fees 932 693 Deferred rent, current portion 555 555 Accrued other 497 653 $ 8,261 $ 7,670 |
Stock-Based Awards
Stock-Based Awards | 9 Months Ended |
Sep. 30, 2021 | |
Stock-Based Awards | 5. Stock-Based Awards 2018 Stock Option and Incentive Plan The Company grants stock-based awards under the Magenta Therapeutics, Inc. 2018 Stock Option and Incentive Plan (the “2018 Plan”). The Company also has outstanding stock options under the Magenta Therapeutics, Inc. 2016 Stock Option and Grant Plan, as amended (the “2016 Plan”), but is no longer granting awards under the 2016 Plan. As of September 30, 2021, 3,151,538 shares of common stock were available for issuance under the 2018 Plan. 2019 Employee Stock Purchase Plan Employees may elect to participate in The Magenta Therapeutics, Inc. 2019 Employee Stock Purchase Plan (the “ESPP”). The purchase price of common stock under the ESPP is equal to 85% of the lower of the fair market value of the common stock on the offering date or the exercise date. The six-month offering Grant of Stock Options During the nine months ended September 30, 2021, the Company granted options to certain employees and directors with service-based vesting conditions for the purchase of 2,526,457 shares of common stock with a weighted average grant date fair value of $6.68 per share. Stock-based compensation expense is being recognized over the requisite service period of four years. Grant of Restricted Stock Units During the nine months ended September 30, 2021, the Company granted 275,625 restricted stock units to certain employees with a weighted average grant date fair value of $8.07 per share. Stock-based compensation expense is being recognized over the requisite service period of three years. Grant of Performance Restricted Stock Units During the nine months ended September 30, 2021, the Company granted 300,000 performance-based restricted stock units to certain employees with a weighted average grant date fair value of $10.65 per share. These performance-based restricted stock units vest upon the occurrence of certain operational and financial events. At the achievement of the performance-based vesting criteria, each performance-based restricted stock unit entitles the holder to a specified number of shares of common stock. During the three and nine months ended September 30, 2021, the Company recorded stock compensation expense of $1.7 million related to the vesting of 170,000 performance-based restricted stock units. Stock-Based Compensation Stock-based compensation expense was classified in the statements of operations and comprehensive loss as follows (in thousands): Three Months Ended September 30, Nine Months Ended September 30, 2021 2020 2021 2020 Research and development expenses $ 1,335 $ 878 $ 3,276 $ 2,680 General and administrative expenses 2,464 1,488 4,849 4,930 $ 3,799 $ 2,366 $ 8,125 $ 7,610 As of September 30, 2021, unrecognized compensation expense related to unvested share-based awards with service-based vesting conditions was $21.8 million, which is expected to be recognized over a weighted average period of 2.9 years. Additionally, the Company had unrecognized compensation cost of $1.7 million related to the unvested performance restricted stock units for which the performance conditions were not considered probable of achievement as of September 30, 2021. |
Commitments and Contingencies
Commitments and Contingencies | 9 Months Ended |
Sep. 30, 2021 | |
Commitments and Contingencies | 6. Commitments and Contingencies Leases In May 2018, the Company entered into a sublease, as amended, for up to approximately 69,000 square feet of office and laboratory space in Cambridge, Massachusetts. The sublease is subject and subordinate to a prime lease between the sublandlord and the prime landlord. The term of the sublease commenced in June 2018 and expires in February 2028. The sublandlord has the right to terminate the sublease after five years. The Company is obligated to pay real estate taxes and other costs related to the premises, including costs of operations and management of the leased premises. In connection with the sublease, as amended, the sublandlord funded $5.2 million in tenant improvements to the leased facility during 2019. The Company is required to maintain a cash balance of $1.8 million to secure a letter of credit associated with the sublease. This amount was classified as noncurrent restricted cash in the consolidated balance sheets at September 30, 2021 and December 31, 2020. As of September 30, 2021 and December 31, 2020, the Company had long-term deferred rent of $6.4 million and $6.3 million, respectively, related to lease incentives and payment escalations. As of September 30, 2021 and December 31, 2020, the short-term portion of deferred rent of $0.6 million for each period was included in accrued expenses and other current liabilities. The Company recorded rent expense of $1.5 million during each of the three months ended September 30, 2021 and 2020. The Company recorded rent expense of $4.6 million during each of the nine months ended September 30, 2021 and 2020. As of September 30, 2021, the future minimum lease payments due under the noncancelable operating lease was as follows (in thousands): Remainder of 2021 (three months) $ 1,549 2022 6,375 2023 6,734 2024 7,100 2025 7,455 Thereafter 17,444 $ 46,657 In 2018, the Company entered into two two-year sub-subleases sub-subleases sub-sublease sub-subleases sub-subleases. sub-subleases. Collaboration Agreement In March 2018, the Company entered into a collaboration agreement with Heidelberg Pharma Research GmbH (“HDPR”) whereby the parties agreed to combine the Company’s stem cell platform with proprietary antibodies across up to four exclusive targets with HDPR’s proprietary Antibody Targeted Amanitin Conjugates platform. Under the agreement, the Company may pay upfront technology access fees, research exclusivity fees and payment for research support. Additionally, upon the exercise of certain license rights, the Company may be obligated to pay HDPR development, regulatory and commercial milestone payments of up to $83.5 million per target as well as royalties on net sales of products licensed under the agreement. During the three months ended September 30, 2021 and 2020, the Company recorded less than $0.1 million and $0.3 million, respectively, of research and development expense related to this agreement for upfront technology access fees, research exclusivity fees and research support. During the nine months ended September 30, 2021 and 2020, the Company recorded $0.4 million and $0.6 million, respectively, of research and development expense related to this agreement for upfront technology access fees, research exclusivity fees and research support. Intellectual Property Licenses The Company has a license agreement with the President and Fellows of Harvard College (“Harvard”), entered into in November 2016, for an exclusive, worldwide, royalty-bearing license for certain technologies related to conditioning and mobilization. The Company is obligated to pay Harvard maintenance fees of product-by-product country-by-country The Company has a license agreement with Novartis International Pharmaceutical Ltd. (“Novartis”), entered into in April 2017, to use and develop certain patent rights (the “Novartis License”). Under the Novartis License, the Company was granted an exclusive, worldwide, sublicensable license to research, develop and commercialize certain licensed products that contain Novartis compounds for the expansion of cord blood derived non-gene-edited/-modified product-by-product country-by-country The Company has agreements with third parties in the normal course of business, under which it can license certain developed technologies. If the Company exercises its rights to license the respective technologies, it may be subject to additional fees and milestone payments. During the three and nine months ended September 30, 2021 and 2020, the Company did not incur any expense related to these licenses. Indemnification Agreements In the ordinary course of business, the Company may provide indemnification of varying scope and terms to vendors, lessors, business partners and other parties with respect to certain matters including, but not limited to, losses arising out of breach of such agreements or from intellectual property infringement claims made by third parties. In addition, the Company has entered into indemnification agreements with members of its board of directors and senior management that will require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors or officers. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is, in many cases, unlimited. To date, the Company has not incurred any material costs as a result of such indemnifications. The Company is not aware of any claims under indemnification arrangements, and it has not accrued any liabilities related to such obligations in its consolidated financial statements as of September 30, 2021. Legal Proceedings The Company is not currently a party to any material legal proceedings. At each reporting date, the Company evaluates whether or not a potential loss amount or a potential range of loss is probable and reasonably estimable under the provisions of the authoritative guidance that addresses accounting for contingencies. The Company expenses the costs related to its legal proceedings as they are incurred. |
401(k) Savings Plan
401(k) Savings Plan | 9 Months Ended |
Sep. 30, 2021 | |
401(k) Savings Plan | 7. 401(k) Savings Plan The Company has a 401(k) available for participating employees who meet certain eligibility requirements. Eligible employees may defer a portion of their salary as defined by the plan. Company contributions to the plan may be made at the discretion of the board of directors of the Company. Effective August 2021, the Company began making matching contributions of up to 2% of eligible wages. During the three and nine months ended September 30, 2021, the Company recorded less than $0.1 million of expense related to this matching contribution. |
Related Parties
Related Parties | 9 Months Ended |
Sep. 30, 2021 | |
Related Parties | 8. Related Parties National Marrow Donor Program (as successor in interest to Be The Match BioTherapies Collection Services, LLC (formerly known as Be The Match BioTherapies, LLC)) Effective March 2018, Amy Lynn Ronneberg, the then serving President of Be The Match BioTherapies, LLC, became a member of the Company’s board of directors and subsequently was appointed Chief Executive Officer of the National Marrow Donor Program/Be The Match, or NMDP/Be The Match, organization in June 2020. The Company has collaboration agreements with the National Marrow Donor Program (as successor in interest to Be The Match BioTherapies Collection Services, LLC (formerly known as Be The Match BioTherapies, LLC)) and a research agreement with an affiliated organization, Center for International Blood and Marrow Transplant Research. In addition, in June 2020, the Company entered into a clinical collaboration agreement with NMDP/Be The Match to evaluate the potential utility of MGTA-145 For the three months ended September 30, 2021 and 2020, the Company recorded expense of $0.2 million and $0.1 million, respectively, related to these agreements. For the nine months ended September 30, 2021 and 2020, the Company recorded expense of $0.5 million and $0.3 million, respectively, related to these agreements. As of September 30, 2021 and December 31, 2020, amounts on the consolidated balance sheets related to these agreements were less than $ |
Summary of Significant Accoun_2
Summary of Significant Accounting Policies (Policies) | 9 Months Ended |
Sep. 30, 2021 | |
Use of Estimates | Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting periods. Significant estimates and assumptions reflected in these financial statements include, but are not limited to, the accrual for research and development expenses and the valuation of stock-based awards. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates. |
Unaudited Interim Financial Information | Unaudited Interim Financial Information The consolidated balance sheet at December 31, 2020 was derived from audited financial statements but does not include all disclosures required by GAAP. The accompanying unaudited consolidated financial statements as of September 30, 2021 and for the three and nine months ended September 30, 2021 and 2020 have been prepared by the Company pursuant to the rules and regulations of the SEC for interim financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to such rules and regulations. The Company believes, however, that the disclosures are adequate to make the information presented not misleading. These consolidated financial statements should be read in conjunction with the Company’s audited financial statements for the year ended December 31, 2020 included in the Company’s Annual Report on Form 10-K, |
Fair Value Measurements | Fair Value Measurements Certain assets and liabilities are carried at fair value under GAAP. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy, of which the first two are considered observable and the last is considered unobservable: • Level 1—Quoted prices in active markets for identical assets or liabilities. • Level 2—Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable market data. • Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques. The Company’s cash equivalents and marketable securities are carried at fair value, determined according to the fair value hierarchy described above (see Note 3). The carrying values of the Company’s accounts payable and accrued expenses approximate their fair values due to the short-term nature of these assets and liabilities. Income Taxes |
Income Taxes | The Company accounts for income taxes using the asset and liability method, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been recognized in the consolidated financial statements or in the Company’s tax returns. Deferred taxes are determined based on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect in the years in which the differences are expected to reverse. Changes in deferred tax assets and liabilities are recorded in the provision for income taxes. The Company assesses the likelihood that its deferred tax assets will be recovered from future taxable income and, to the extent it believes, based upon the weight of available evidence, that it is more likely than not that all or a portion of deferred tax assets will not be realized, a valuation allowance is established through a charge to income tax expense. Potential for recovery of deferred tax assets is evaluated by estimating the future taxable profits expected and considering prudent and feasible tax planning strategies. The Company accounts for uncertainty in income taxes recognized in its consolidated financial statements by applying a two-step more-likely-than-not |
Comprehensive Loss | Comprehensive Loss Comprehensive loss includes net loss as well as other changes in stockholders’ equity that result from transactions and economic events other than those with stockholders. For the three and nine months ended September 30, 2021 and 2020, the Company’s only element of other comprehensive income (loss) was unrealized gains (losses) on marketable securities. |
Net Loss per Share | Net Loss per Share Basic net income (loss) per share is computed by dividing the net income (loss) by the weighted average number of shares of common stock outstanding for the period. Diluted net income (loss) per share is computed by dividing net income (loss) by the weighted average number of common shares outstanding for the period, including potential dilutive common shares assuming the dilutive effect of outstanding stock options. For periods in which the Company has reported net losses, diluted net loss per common share is the same as basic net loss per common share, since dilutive common shares are not assumed to have been issued if their affect is anti-dilutive. The Company reported a net loss for the three and nine months ended September 30, 2021 and 2020. The following potential dilutive securities, presented based on amounts outstanding at each period end, have been excluded from the calculation of diluted net loss per share because including them would have had an anti-dilutive impact: As of September 30, 2021 2020 Stock options to purchase common stock 6,091,220 5,782,911 Unvested restricted common stock and units 497,418 251,723 Shares of common stock issuable under Employee Stock Purchase Plan 8,843 8,213 6,597,481 6,042,847 |
Recently Issued Accounting Pronouncements | Recently Issued Accounting Pronouncements In February 2016, the FASB issued ASU No. 2016-02, Leases 2016-02”). 2016-02 right-of-use No. 2020-05, 2016-02 2018-11, Leases (Topic 842) Targeted Improvements 2016-02 right-of-use In June 2016, the FASB issued ASU No. 2016-13, Financial Instruments – Credit Losses (Topic 326) No. 2019-10, |
Summary of Significant Accoun_3
Summary of Significant Accounting Policies (Tables) | 9 Months Ended |
Sep. 30, 2021 | |
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share | The following potential dilutive securities, presented based on amounts outstanding at each period end, have been excluded from the calculation of diluted net loss per share because including them would have had an anti-dilutive impact: As of September 30, 2021 2020 Stock options to purchase common stock 6,091,220 5,782,911 Unvested restricted common stock and units 497,418 251,723 Shares of common stock issuable under Employee Stock Purchase Plan 8,843 8,213 6,597,481 6,042,847 |
Fair Value of Financial Assets
Fair Value of Financial Assets (Tables) | 9 Months Ended |
Sep. 30, 2021 | |
Schedule of Marketable Securities by Security Type | As of September 30, 2021, marketable securities by security type consisted of (in thousands): Gross Gross Estimated Amortized Unrealized Unrealized Fair Cost Gains Losses Value U.S. treasury notes (due within one year) $ 35,076 $ 1 $ — $ 35,077 Total $ 35,076 $ 1 $ — $ 35,077 As of December 31, 2020, marketable securities by security type consisted of (in thousands): Gross Gross Estimated Amortized Unrealized Unrealized Fair Cost Gains Losses Value U.S. treasury notes (due within one year) $ 90,706 $ — $ (23 ) $ 90,683 Total $ 90,706 $ — $ (23 ) $ 90,683 |
Schedule of Financial Assets Measured at Fair Value on Recurring Basis | The following tables present information about the Company’s financial assets measured at fair value on a recurring basis and indicate the level of the fair value hierarchy utilized to determine such fair values (in thousands): Fair Value Measurements at September 30, 2021 Using: Level 1 Level 2 Level 3 Total Cash equivalents: Money market funds $ 157,781 $ — $ — $ 157,781 Marketable securities: U.S. treasury notes — 35,077 — 35,077 Total $ 157,781 $ 35,077 $ — $ 192,858 Fair Value Measurements at December 31, 2020 Using: Level 1 Level 2 Level 3 Total Cash equivalents: Money market funds $ 43,182 $ — $ — $ 43,182 U.S. treasury notes — 14,999 — 14,999 Marketable securities: U.S. treasury notes — 90,683 — 90,683 Total $ 43,182 $ 105,682 $ — $ 148,864 |
Accrued Expenses and Other Cu_2
Accrued Expenses and Other Current Liabilities (Tables) | 9 Months Ended |
Sep. 30, 2021 | |
Schedule of Accrued Expenses and Other Current Liabilities | Accrued expenses and other current liabilities consisted of the following (in thousands): September 30, 2021 December 31, 2020 Accrued external research and development expenses $ 3,294 $ 2,662 Accrued payroll and related expenses 2,983 3,107 Accrued professional fees 932 693 Deferred rent, current portion 555 555 Accrued other 497 653 $ 8,261 $ 7,670 |
Stock-Based Awards (Tables)
Stock-Based Awards (Tables) | 9 Months Ended |
Sep. 30, 2021 | |
Schedule of Stock Based Compensation Expense | Stock-based compensation expense was classified in the statements of operations and comprehensive loss as follows (in thousands): Three Months Ended September 30, Nine Months Ended September 30, 2021 2020 2021 2020 Research and development expenses $ 1,335 $ 878 $ 3,276 $ 2,680 General and administrative expenses 2,464 1,488 4,849 4,930 $ 3,799 $ 2,366 $ 8,125 $ 7,610 |
Commitments and Contingencies (
Commitments and Contingencies (Tables) | 9 Months Ended |
Sep. 30, 2021 | |
Schedule of Future Minimum Lease Payments Due Under Noncancelable Operating Lease | As of September 30, 2021, the future minimum lease payments due under the noncancelable operating lease was as follows (in thousands): Remainder of 2021 (three months) $ 1,549 2022 6,375 2023 6,734 2024 7,100 2025 7,455 Thereafter 17,444 $ 46,657 |
Nature of the Business and Ba_2
Nature of the Business and Basis of Presentation - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands | Jun. 30, 2020 | Aug. 08, 2019 | May 31, 2021 | Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | Dec. 31, 2020 |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] | ||||||||
Entity incorporation date | Jun. 1, 2015 | |||||||
Entity incorporation state code | DE | |||||||
Net loss | $ (17,427) | $ (17,678) | $ (51,844) | $ (56,768) | $ (74,900) | |||
Accumulated deficit | $ (306,275) | $ (306,275) | $ (254,431) | |||||
Net proceeds from common stock | $ 64,860 | |||||||
Maximum [Member] | ||||||||
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] | ||||||||
Shelf offering value | $ 350,000 | |||||||
Private Placement [Member] | ||||||||
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] | ||||||||
Stock issued, shares | 9,599,998 | |||||||
Stock issued, price per shares | $ 9 | |||||||
Sale of stock net consideration received on the transaction | $ 86,100 | |||||||
Common Stock [Member] | ||||||||
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] | ||||||||
Stock issued, shares | 8,625,000 | 8,625,000 | ||||||
Stock issued, price per shares | $ 8 | |||||||
Net proceeds from common stock | $ 64,600 | |||||||
Common Stock [Member] | Private Placement [Member] | ||||||||
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] | ||||||||
Stock issued, shares | 9,599,998 | |||||||
Cowen and Company LLC [Member] | Maximum [Member] | ||||||||
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] | ||||||||
ATM offering value | $ 100,000 |
Summary of Significant Accoun_4
Summary of Significant Accounting Policies - Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share (Detail) - shares | 9 Months Ended | |
Sep. 30, 2021 | Sep. 30, 2020 | |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||
Anti-dilutive securities excluded from computation of earnings per share, amount | 6,597,481 | 6,042,847 |
Stock Option [Member] | ||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||
Anti-dilutive securities excluded from computation of earnings per share, amount | 6,091,220 | 5,782,911 |
Restricted Stock [Member] | ||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||
Anti-dilutive securities excluded from computation of earnings per share, amount | 497,418 | 251,723 |
Shares of common stock issuable under the ESPP [Member] | ||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||
Anti-dilutive securities excluded from computation of earnings per share, amount | 8,843 | 8,213 |
Fair Value of Financial Asset_2
Fair Value of Financial Assets - Schedule of Marketable Securities by Security Type (Detail) - USD ($) $ in Thousands | Sep. 30, 2021 | Dec. 31, 2020 |
Marketable Securities [Line Items] | ||
Amortized Cost | $ 35,076 | $ 90,706 |
Gross Unrealized Gains | 1 | |
Gross Unrealized Losses | (23) | |
Estimated Fair Value | 35,077 | 90,683 |
United States Treasury Notes [Member] | ||
Marketable Securities [Line Items] | ||
Amortized Cost | 35,076 | 90,706 |
Gross Unrealized Gains | 1 | |
Gross Unrealized Losses | (23) | |
Estimated Fair Value | $ 35,077 | $ 90,683 |
Fair Value of Financial Asset_3
Fair Value of Financial Assets - Schedule of Financial Assets Measured at Fair Value on Recurring Basis (Detail) - USD ($) $ in Thousands | Sep. 30, 2021 | Dec. 31, 2020 |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Marketable securities | $ 35,077 | $ 90,683 |
Fair Value on Recurring Basis [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total | 192,858 | 148,864 |
Level 1 [Member] | Fair Value on Recurring Basis [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total | 157,781 | 43,182 |
Level 2 [Member] | Fair Value on Recurring Basis [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total | 35,077 | 105,682 |
Money Market Funds [Member] | Fair Value on Recurring Basis [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 157,781 | 43,182 |
Money Market Funds [Member] | Level 1 [Member] | Fair Value on Recurring Basis [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 157,781 | 43,182 |
United States Treasury Notes [Member] | Fair Value on Recurring Basis [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 14,999 | |
Marketable securities | 35,077 | |
United States Treasury Notes [Member] | Level 2 [Member] | Fair Value on Recurring Basis [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 14,999 | |
Marketable securities | 35,077 | |
United States Treasury Notes [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Marketable securities | $ 35,077 | 90,683 |
United States Treasury Notes [Member] | Fair Value on Recurring Basis [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Marketable securities | 90,683 | |
United States Treasury Notes [Member] | Level 2 [Member] | Fair Value on Recurring Basis [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Marketable securities | $ 90,683 |
Accrued Expenses and Other Cu_3
Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands | Sep. 30, 2021 | Dec. 31, 2020 |
Payables and Accruals [Abstract] | ||
Accrued external research and development expenses | $ 3,294 | $ 2,662 |
Accrued payroll and related expenses | 2,983 | 3,107 |
Accrued professional fees | 932 | 693 |
Deferred rent, current portion | 555 | 555 |
Accrued other | 497 | 653 |
Total | $ 8,261 | $ 7,670 |
Stock-Based Awards - Additional
Stock-Based Awards - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Total unrecognized stock-based compensation expense | $ 21,800 | $ 21,800 | ||
Period for recognition of unrecognized expense | 2 years 10 months 24 days | |||
Stock compensation expense | 3,799 | $ 2,366 | $ 8,125 | $ 7,610 |
Employees And Directors [Member] | ||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Share-based compensation arrangement by share-based payment award, options, grants in period, gross | 2,526,457 | |||
Weighted average fair value of stock options granted | $ 6.68 | |||
Share based compensation arrangement , requisite service period | 4 years | |||
Restricted Stock [Member] | ||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Total unrecognized stock-based compensation expense | 1,700 | $ 1,700 | ||
Performance Shares [member] | ||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Stock compensation expense | $ 1,700 | $ 1,700 | ||
Grant of restricted stock | 300,000 | |||
Grant weighted average grant date fair value per share | $ 10.65 | |||
Stock compensation expense related to the vesting of performance based restricted stock units | 170,000 | 170,000 | ||
Restricted Stock Units (RSUs) [Member] | Employees [Member] | ||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Grant of restricted stock | 275,625 | |||
Grant weighted average grant date fair value per share | $ 8.07 | |||
Share based compensation arrangement , requisite service period | 3 years | |||
2018 Stock Option and Incentive Plan [Member] | ||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Common stock available for issuance | 3,151,538 | 3,151,538 | ||
2019 Employee Stock Purchase Plan [Member] | ||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Common stock available for issuance | 136,835 | 136,835 | ||
Percentage of purchase price of common stock under the ESPP | 85.00% | |||
Common stock purchased | 13,989 | 5,653 | ||
Stock issued, price per shares | $ 6.15 | $ 7.51 | $ 6.15 | $ 7.51 |
Stock-Based Awards - Schedule o
Stock-Based Awards - Schedule of Stock Based Compensation Expense (Detail) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | ||||
Stock based compensation expense | $ 3,799 | $ 2,366 | $ 8,125 | $ 7,610 |
Research and Development Expenses [Member] | ||||
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | ||||
Stock based compensation expense | 1,335 | 878 | 3,276 | 2,680 |
General and Administrative Expenses [Member] | ||||
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | ||||
Stock based compensation expense | $ 2,464 | $ 1,488 | $ 4,849 | $ 4,930 |
Commitments and Contingencies -
Commitments and Contingencies - Additional Information (Detail) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended | ||||||
Apr. 30, 2017USD ($) | Sep. 30, 2021USD ($) | Sep. 30, 2020USD ($) | Dec. 31, 2018ft²Sublease | Sep. 30, 2021USD ($)Milestone | Sep. 30, 2020USD ($) | Dec. 31, 2020USD ($) | May 31, 2018USD ($)ft² | Nov. 30, 2016USD ($) | |
Other Commitments [Line Items] | |||||||||
Sublease commencement period | 2018-06 | ||||||||
Sublease expiration period | 2028-02 | ||||||||
Property sublease, description | In May 2018, the Company entered into a sublease, as amended, for up to approximately 69,000 square feet of office and laboratory space in Cambridge, Massachusetts. The sublease is subject and subordinate to a prime lease between the sublandlord and the prime landlord. The term of the sublease commenced in June 2018 and expires in February 2028. The sublandlord has the right to terminate the sublease after five years. | ||||||||
Sublease termination period | 5 years | ||||||||
Long-term deferred rent | $ 6,401 | $ 6,401 | $ 6,283 | ||||||
Deferred rent, current portion | 555 | 555 | 555 | ||||||
Rent expense | 1,500 | $ 1,500 | 4,600 | $ 4,600 | |||||
Rental payments receivable | 1,000 | 1,000 | |||||||
Research and development expense | 10,795 | 11,786 | 33,652 | 38,359 | |||||
Research and Development Expenses [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Research and development expense | 100 | ||||||||
Long Term Deferred Rent [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Long-term deferred rent | 6,400 | 6,400 | 6,300 | ||||||
Short Term Deferred Rent [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Deferred rent, current portion | 600 | 600 | $ 600 | ||||||
Maximum [Member] | Office and Lab Sublease [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Square feet of property subject to sublease | ft² | 69,000 | ||||||||
Tenant improvement allowance | $ 5,200 | ||||||||
Sub-Sublease [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Square feet of property subject to sublease | ft² | 27,000 | ||||||||
Lease agreement maturity period | 2 years | ||||||||
Number of Sub-sublease | Sublease | 2 | ||||||||
Other income from sub-sublease | 800 | 600 | $ 2,700 | 2,000 | |||||
License Agreement with Novartis International Pharmaceutical Ltd. [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Number of milestones met | Milestone | 0 | ||||||||
License Agreement with Novartis International Pharmaceutical Ltd. [Member] | Maximum [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
License agreement royalty percentage | 20.00% | ||||||||
License Agreement with Novartis International Pharmaceutical Ltd. [Member] | Achievement of Clinical and Regulatory Milestones [Member] | Maximum [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Payment obligation | $ 177,000 | ||||||||
License Agreement with Novartis International Pharmaceutical Ltd. [Member] | Development and Regulatory Milestones [Member] | Maximum [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Payment obligation | $ 125,000 | ||||||||
Collaboration Agreement [Member] | Maximum [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Research and development expense | 100 | 300 | $ 400 | $ 600 | |||||
Collaboration Agreement [Member] | Development, Regulatory and Commercial Milestone [Member] | Per Target [Member] | Maximum [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Payment obligation | 83,500 | $ 83,500 | |||||||
License Agreement With Harvard [Member] | Maintenance [Member] | Annually Through 2019 [Member] | Maximum [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Payment obligation | $ 100 | ||||||||
License Agreement With Harvard [Member] | Achievement of Development and Regulatory Milestones [Member] | Maximum [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Payment obligation | $ 7,400 | ||||||||
License Agreement With Third Parties [Member] | License [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Research and development expense | $ 0 | $ 0 | |||||||
Letter of Credit [Member] | Office and Lab Sublease [Member] | |||||||||
Other Commitments [Line Items] | |||||||||
Cash balance to secure letter of credit associated with sublease | $ 1,800 |
Commitments and Contingencies_2
Commitments and Contingencies - Schedule of Future Minimum Lease Payments Due Under Noncancelable Operating Lease (Detail) $ in Thousands | Sep. 30, 2021USD ($) |
Operating Leased Assets [Line Items] | |
Remainder of 2021 (three months) | $ 1,549 |
2022 | 6,375 |
2023 | 6,734 |
2024 | 7,100 |
2025 | 7,455 |
Thereafter | 17,444 |
Operating leases future minimum payments due | $ 46,657 |
401(k) Savings Plan - Additiona
401(k) Savings Plan - Additional Information (Details) - USD ($) $ in Millions | 3 Months Ended | 9 Months Ended |
Sep. 30, 2021 | Sep. 30, 2021 | |
Retirement Benefits [Abstract] | ||
Defined contribution plan,Employers matching contributions subject to time based vesting requirements | 2.00% | |
Defined contribution plan, Employer discretionary contribution amount | $ 0.1 | $ 0.1 |
Related Parties - Additional In
Related Parties - Additional Information (Detail) - USD ($) $ in Millions | 3 Months Ended | 9 Months Ended | |||
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | Dec. 31, 2020 | |
Related Party Transaction [Line Items] | |||||
Amounts owed to related party | $ 0.1 | $ 0.1 | $ 0.1 | ||
Match Bio Therapies [Member] | |||||
Related Party Transaction [Line Items] | |||||
Expenses paid to related party | 0.2 | $ 0.1 | 0.5 | $ 0.3 | |
Match Bio Therapies [Member] | Prepaid Expenses and Other Current Assets [Member] | |||||
Related Party Transaction [Line Items] | |||||
Amounts owed to related party | $ 0.1 | $ 0.1 | $ 0.1 |