| | Year Ended | |
| | December 31, | |
(in thousands of $ except for shares and EPS) | | 2023 | | | 2022 | | | 2021 | |
Product net sales | | $ | 1,190,783 | | | $ | 400,720 | | | $ | — | |
Collaboration revenue | | | 35,533 | | | | 10,026 | | | | 497,277 | |
Other operating income | | | 42,278 | | | | 34,520 | | | | 42,141 | |
Total operating income | | | 1,268,594 | | | | 445,267 | | | | 539,418 | |
| | | | | | | | | | | | |
Cost of sales | | | (117,835 | ) | | | (29,431 | ) | | | — | |
Research and development expenses | | | (859,492 | ) | | | (663,366 | ) | | | (580,520 | ) |
Selling, general and administrative expenses | | | (711,905 | ) | | | (472,132 | ) | | | (307,644 | ) |
Loss from investment in joint venture | | | (4,411 | ) | | | (677 | ) | | | — | |
Total operating expenses | | | (1,693,643 | ) | | | (1,165,607 | ) | | | (888,164 | ) |
| | | | | | | | | | | | |
Operating loss | | $ | (425,049 | ) | | $ | (720,341 | ) | | $ | (348,746 | ) |
| | | | | | | | | | | | |
Financial income | | | 107,386 | | | | 27,665 | | | | 3,633 | |
Financial expense | | | (906 | ) | | | (3,906 | ) | | | (4,578 | ) |
Exchange gains/(losses) | | | 14,073 | | | | (32,732 | ) | | | (50,053 | ) |
| | | | | | | | | | | | |
Loss for the year before taxes | | $ | (304,496 | ) | | $ | (729,314 | ) | | $ | (399,743 | ) |
Income tax benefit / (expense) | | $ | 9,443 | | | $ | 19,720 | | | $ | (8,522 | ) |
Loss for the year | | $ | (295,053 | ) | | $ | (709,594 | ) | | $ | (408,265 | ) |
Loss for the year attributable to: | | | | | | | | | | | | |
Owners of the parent | | | (295,053 | ) | | $ | (709,594 | ) | | $ | (408,265 | ) |
Weighted average number of shares outstanding | | | 57,169,253 | | | | 54,381,371 | | | | 51,075,827 | |
Basic and diluted (loss) per share (in $) | | | (5.16 | ) | | | (13.05 | ) | | | (7.99 | ) |
| | Year Ended | |
| | December 31, | |
(in thousands of $) | | 2023 | | | 2022 | | | 2021 | |
Operating loss | | $ | (425,049 | ) | | $ | (720,341 | ) | | $ | (348,746 | ) |
Adjustments for non-cash items | | | | | | | | | | | | |
Amortization of intangible assets | | | 105,674 | | | | 99,766 | | | | 776 | |
Depreciation of property, plant and equipment | | | 5,633 | | | | 4,576 | | | | 5,091 | |
Provisions for employee benefits | | | 573 | | | | 459 | | | | 260 | |
Expense recognized in respect of share-based payments | | | 232,974 | | | | 157,026 | | | | 179,366 | |
Fair value gains on financial assets at fair value through profit or loss | | | — | | | | (4,256 | ) | | | (11,152 | ) |
Non-cash revenue | | | — | | | | — | | | | (75,000 | ) |
Loss from investment in joint venture | | | 4,411 | | | | 677 | | | | — | |
Other non-cash expenses | | | 2,074 | | | | — | | | | — | |
| | $ | (73,710 | ) | | $ | (462,093 | ) | | $ | (249,405 | ) |
Movements in current assets/liabilities | | | | | | | | | | | | |
(Increase)/decrease in trade and other receivables | | | (185,694 | ) | | | (222,260 | ) | | | (31,632 | ) |
(Increase)/decrease in inventories | | | (83,030 | ) | | | (119,277 | ) | | | (83,880 | ) |
(Increase)/decrease in other current assets | | | (59,024 | ) | | | (18,294 | ) | | | (30,990 | ) |
Increase/(decrease) in trade and other payables | | | 95,600 | | | | 329 | | | | 134,892 | |
Increase/(decrease) in deferred revenue — current | | | — | | | | — | | | | (46,327 | ) |
Movements in non-current assets/liabilities | | | | | | | | | | | | |
(Increase)/decrease in other non-current assets | | | (29,416 | ) | | | (16,220 | ) | | | (13,975 | ) |
(Increase)/decrease in non-current prepaid expense | | | (47,327 | ) | | | — | | | | — | |
Increase/(decrease) in deferred revenue �� non-current | | | — | | | | — | | | | (269,039 | ) |
| | | | | | | | | | | | |
Net cash flows used in operating activities | | | (382,601 | ) | | | (837,815 | ) | | | (590,356 | ) |
| | | | | | | | | | | | |
Interest paid | | | (211 | ) | | | (851 | ) | | | (684 | ) |
Income taxes paid | | | (37,515 | ) | | | (24,141 | ) | | | (15,772 | ) |
| | | | | | | | | | | | |
Net cash flows used in operating activities | | $ | (420,327 | ) | | $ | (862,807 | ) | | $ | (606,812 | ) |
| | | | | | | | | | | | |
Purchase of intangible assets | | | (43,000 | ) | | | (102,986 | ) | | | (117,811 | ) |
Purchase of property, plant and equipment | | | (812 | ) | | | (837 | ) | | | (3,623 | ) |
(Increase)/decrease in current financial assets | | | — | | | | — | | | | (228,239 | ) |
Purchase of current financial investments | | | (1,271,730 | ) | | | (1,694,046 | ) | | | — | |
Sale of current financial investments | | | 1,543,999 | | | | 1,325,540 | | | | — | |
Interest received | | | 92,753 | | | | 13,146 | | | | 2,603 | |
Investment in joint venture | | | (13,000 | ) | | | (2,000 | ) | | | — | |
| | | | | | | | | | | | |
Net cash flows (used in) / from investing activities | | $ | 308,210 | | | $ | (461,184 | ) | | $ | (347,070 | ) |
| | | | | | | | | | | | |
Principal elements of lease payments | | | (3,801 | ) | | | (4,165 | ) | | | (3,855 | ) |
Proceeds from issue of new shares, gross amount | | | 1,196,731 | | | | 760,953 | | | | 1,091,326 | |
Issue costs paid | | | (821 | ) | | | (781 | ) | | | (528 | ) |
Exchange gain/(losses) from currency conversion on proceeds from issue of new shares | | | (1,507 | ) | | | 410 | | | | 966 | |
Payment of employee withholding taxes relating to restricted stock unit awards | | | (12,138 | ) | | | (5,855 | ) | | | — | |
Proceeds from exercise of stock options | | | 158,263 | | | | 93,195 | | | | 33,433 | |
| | | | | | | | | | | | |
Net cash flows from financing activities | | $ | 1,336,727 | | | $ | 843,757 | | | $ | 1,121,342 | |
| | | | | | | | | | | | |
Increase/decrease (-) in cash and cash equivalents | | $ | 1,224,610 | | | $ | (480,234 | ) | | $ | 167,460 | |
| | | | | | | | | | | | |
Cash and cash equivalents at the beginning of the period | | $ | 800,740 | | | $ | 1,334,676 | | | $ | 1,216,803 | |
Exchange gains/(losses) on cash and cash equivalents | | $ | 23,494 | | | $ | (53,702 | ) | | $ | (49,587 | ) |
Cash and cash equivalents at the end of the period | | $ | 2,048,844 | | | $ | 800,740 | | | $ | 1,334,676 | |
| | Attributable to owners of the parent | |
| | | | | | | | | | | | | | Share-based | | | | | | Total | | | | |
| | | | | | | | | | | | | | payment and | | | | | | equity | | | | |
| | | | | | | | | | | | | | income tax | | | Fair value movement on | | | attributable | | | | |
| | | | | | | | | | | | | | deduction on | | | investment in equity | | | to owners | | | | |
| | Share | | | Share | | | Accumulated | | | Translation | | | share-based | | | instruments designated | | | of the | | | Total | |
(in thousands of $) | | capital | | | premium | | | losses | | | differences | | | payments | | | as at FVTOCI | | | parent | | | equity | |
Balance at January 1, 2021 | | $ | 5,744 | | | $ | 2,339,033 | | | $ | (991,932 | ) | | $ | 134,732 | | | $ | 186,474 | | | $ | — | | | $ | 1,674,051 | | | $ | 1,674,051 | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Loss for the year | | | | | | | | | | | (408,265 | ) | | | | | | | | | | | | | | | (408,265 | ) | | | (408,265 | ) |
Other comprehensive income / (loss) | | | | | | | | | | | | | | | (3,048 | ) | | | | | | | (39,290 | ) | | | (42,338 | ) | | | (42,338 | ) |
Total comprehensive income / (loss) for the year | | | | | | | | | | | (408,265 | ) | | | (3,048 | ) | | | | | | | (39,290 | ) | | | (450,603 | ) | | | (450,603 | ) |
Income tax benefit from excess tax deductions related to share-based payments | | | | | | | | | | | | | | | | | | | 7,179 | | | | | | | | 7,179 | | | | 7,179 | |
Share-based payment | | | | | | | | | | | | | | | | | | | 179,366 | | | | | | | | 179,366 | | | | 179,366 | |
Issue of share capital | | | 430 | | | | 1,090,896 | | | | | | | | | | | | | | | | | | | | 1,091,326 | | | | 1,091,326 | |
Transaction costs for equity issue | | | | | | | (528 | ) | | | | | | | | | | | | | | | | | | | (528 | ) | | | (528 | ) |
Exercise of stock options | | | 59 | | | | 33,374 | | | | | | | | | | | | | | | | | | | | 33,433 | | | | 33,433 | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Balance year ended December 31, 2021 | | $ | 6,233 | | | $ | 3,462,775 | | | $ | (1,400,197 | ) | | $ | 131,684 | | | $ | 373,019 | | | $ | (39,290 | ) | | $ | 2,534,224 | | | $ | 2,534,224 | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Loss for the year | | | | | | | | | | | (709,594 | ) | | | | | | | | | | | | | | | (709,594 | ) | | | (709,594 | ) |
Other comprehensive income / (loss) | | | | | | | | | | | | | | | (2,404 | ) | | | | | | | (18,267 | ) | | | (20,671 | ) | | | (20,671 | ) |
Total comprehensive income / (loss) for the year | | | | | | | | | | | (709,594 | ) | | | (2,404 | ) | | | | | | | (18,267 | ) | | | (730,266 | ) | | | (730,266 | ) |
Income tax benefit from excess tax deductions related to share-based payments | | | | | | | | | | | | | | | | | | | 3,946 | | | | | | | | 3,946 | | | | 3,946 | |
Share-based payment | | | | | | | | | | | | | | | | | | | 158,282 | | | | | | | | 158,282 | | | | 158,282 | |
Issue of share capital | | | 294 | | | | 760,659 | | | | | | | | | | | | | | | | | | | | 760,953 | | | | 760,953 | |
Transaction costs for equity issue | | | | | | | (781 | ) | | | | | | | | | | | | | | | | | | | (781 | ) | | | (781 | ) |
Exercise of stock options | | | 113 | | | | 93,082 | | | | | | | | | | | | | | | | | | | | 93,195 | | | | 93,195 | |
Ordinary shares withheld for payment of employees’ withholding tax liability | | | | | | | (5,855 | ) | | | | | | | | | | | | | | | | | | | (5,855 | ) | | | (5,855 | ) |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Balance year ended December 31, 2022 | | $ | 6,640 | | | | 4,309,880 | | | | (2,109,791 | ) | | | 129,280 | | | | 535,247 | | | | (57,557 | ) | | | 2,813,699 | | | | 2,813,699 | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Loss for the year | | | | | | | | | | | (295,053 | ) | | | | | | | | | | | | | | | (295,053 | ) | | | (295,053 | ) |
Other comprehensive income / (loss) | | | | | | | | | | | | | | | 2,263 | | | | | | | | (1,915 | ) | | | 348 | | | | 348 | |
Total comprehensive income / (loss) for the year | | | | | | | | | | | (295,053 | ) | | | 2,263 | | | | | | | | (1,915 | ) | | | (294,705 | ) | | | (294,705 | ) |
Income tax benefit from excess tax deductions related to share-based payments | | | | | | | | | | | | | | | | | | | 2,310 | | | | | | | | 2,310 | | | | 2,310 | |
Share-based payment | | | | | | | | | | | | | | | | | | | 234,168 | | | | | | | | 234,168 | | | | 234,168 | |
Issue of share capital | | | 288 | | | | 1,196,444 | | | | | | | | | | | | | | | | | | | | 1,196,732 | | | | 1,196,732 | |
Transaction costs for equity issue | | | | | | | (821 | ) | | | | | | | | | | | | | | | | | | | (821 | ) | | | (821 | ) |
Exercise of stock options | | | 130 | | | | 158,133 | | | | | | | | | | | | | | | | | | | | 158,263 | | | | 158,263 | |
Ordinary shares withheld for payment of employees’ withholding tax liability | | | | | | | (12,139 | ) | | | | | | | | | | | | | | | | | | | (12,139 | ) | | | (12,139 | ) |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Balance year ended December 31, 2023 | | $ | 7,058 | | | $ | 5,651,497 | | | $ | (2,404,844 | ) | | $ | 131,543 | | | $ | 771,725 | | | $ | (59,472 | ) | | $ | 4,097,507 | | | $ | 4,097,507 | |