4.3.11 amend theby-laws of the Corporation in such manner, or adopt newby-laws of the Corporation, in either case, that will adversely affect the rights, privileges, restrictions or conditions of the Preferred Shares or the Special Voting Shares;
4.3.12 amend the constating documents of Fusion Ireland (as defined below) in such manner that will adversely affect the rights, privileges, restrictions or conditions of the Exchangeable Shares;
4.3.13 sell or dispose of any assets of the Corporation or any of its subsidiaries with a fair market value in excess of US$250,000 in the aggregate, other than the disposal of equipment that is no longer required by the Corporation or any of its subsidiaries, unless previously approved by a Board Special Majority;
4.3.14 incur indebtedness in excess of US$100,000 in the aggregate, other than trade credit incurred in the ordinary course of business, unless previously approved by a Board Special Majority;
4.3.15 adopt any annual budget, operating budget or business plan of the Corporation or any of its subsidiaries, unless previously approved by a Board Special Majority;
4.3.16 make any change in the strategic direction or lines of business of the Corporation or any of its subsidiaries not specified in the applicable business plan approved by the Board and the Preferred Majority pursuant toSection 4.3.15;
4.3.17 create any subsidiaries, unless previously approved by a Board Special Majority;
4.3.18 make any investment in any other entity or venture, unless previously approved by a Board Special Majority;
4.3.19 commence or terminate the employment of anyC-level employee, including the Chief Executive Officer, Chief Financial Officer, Chief Operating Officer, Chief Medical Officer or Head of Research and/or Development, of the Corporation or amend or revise the terms of any employment agreement with any such officer or employee, unless previously approved by a Board Special Majority;
4.3.20 increase or decrease the size of the Board;
4.3.21 agree to any action which may impair the Corporation’s or any of its subsidiaries’ ability to honour the rights and preferences of the Preferred Shares or the Exchangeable Shares and the Special Voting Shares, taken together, other than in respect of a Tax Distribution;
4.3.22 enter into any contract or agreement with any officer, director, shareholder or employee of the Corporation or any of its subsidiaries or any associate (as defined in the Act) or affiliate (as defined in the Act) of any such person, including for the sale or repurchase of any of the Corporation’s or any of its subsidiaries’ outstanding equity or equity-linked securities, other than (A) in accordance withSection 4.3.3 (B) any contract or agreement entered into with such person on an arms-length basis and approved by the Board (including the approval of at least a majority of disinterested Preferred Directors then appointed) or (C) pursuant to a Tax Distribution;