| Cover - USD ($) | 12 Months Ended | ||
| Jun. 30, 2021 | Dec. 29, 2021 | Dec. 31, 2020 | |
| Cover [Abstract] | |||
| Document Type | 10-K/A | ||
| Amendment Flag | false | ||
| Document Annual Report | true | ||
| Document Transition Report | false | ||
| Document Period End Date | Jun. 30, 2021 | ||
| Document Fiscal Period Focus | FY | ||
| Document Fiscal Year Focus | 2021 | ||
| Current Fiscal Year End Date | --06-30 | ||
| Entity File Number | 001-39727 | ||
| Entity Registrant Name | SCIENCE 37 HOLDINGS, INC. | ||
| Entity Central Index Key | 0001819113 | ||
| Entity Tax Identification Number | 84-4278203 | ||
| Entity Incorporation, State or Country Code | DE | ||
| Entity Address, Address Line One | 800 Park Offices Drive | ||
| Entity Address, Address Line Two | Suite 3606 | ||
| Entity Address, City or Town | Research Triangle Park | ||
| Entity Address, State or Province | NC | ||
| Entity Address, Postal Zip Code | 27709 | ||
| City Area Code | 984 | ||
| Local Phone Number | 377-3737 | ||
| Title of 12(b) Security | Shares of Common Stock, $0.0001 par value | ||
| Trading Symbol | SNCE | ||
| Security Exchange Name | NASDAQ | ||
| Entity Well-known Seasoned Issuer | No | ||
| Entity Voluntary Filers | No | ||
| Entity Current Reporting Status | Yes | ||
| Entity Interactive Data Current | Yes | ||
| Entity Filer Category | Non-accelerated Filer | ||
| Entity Small Business | true | ||
| Entity Emerging Growth Company | true | ||
| Elected Not To Use the Extended Transition Period | false | ||
| Entity Shell Company | true | ||
| Entity Public Float | $ 87,757,186 | ||
| Entity Common Stock, Shares Outstanding | 114,707,150 |
