| Cover | Sep. 29, 2022 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Document Period End Date | Sep. 29, 2022 |
| Entity Registrant Name | SCIENCE 37 HOLDINGS, INC. |
| Entity Incorporation, State or Country Code | DE |
| Entity File Number | 001-39727 |
| Entity Tax Identification Number | 84-4278203 |
| Entity Address, Address Line One | 800 Park Offices Drive |
| Entity Address, Address Line Two | Suite 3606 |
| Entity Address, City or Town | Research Triangle Park |
| Entity Address, State or Province | NC |
| Entity Address, Postal Zip Code | 27709 |
| City Area Code | 984 |
| Local Phone Number | 377-3737 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Shares of Common stock, par value $0.0001 per share |
| Trading Symbol | SNCE |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | true |
| Entity Ex Transition Period | false |
| Entity Central Index Key | 0001819113 |
| Amendment Flag | false |
