| Cover | May 05, 2022 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Document Period End Date | May 23, 2022 |
| Entity Registrant Name | CALADRIUS BIOSCIENCES, INC. |
| Entity Central Index Key | 0000320017 |
| Amendment Flag | false |
| Entity Incorporation, State or Country Code | DE |
| Entity File Number | 001-33650 |
| Entity Tax Identification Number | 22-2343568 |
| Entity Address, Address Line One | 110 Allen Road |
| Entity Address, Address Line Two | Second Floor |
| Entity Address, City or Town | Basking Ridge |
| Entity Address, State or Province | NJ |
| Entity Address, Postal Zip Code | 07920 |
| City Area Code | 908 |
| Local Phone Number | 842-0100 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common Stock, par value $0.001 per share |
| Trading Symbol | CLBS |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | false |
