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New words:
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Removed:
advancing, againstH, Amgen, Augmentin, Avelox, Bayer, Biaxin, bid, bioMerieux, Biosearch, bridge, broader, category, CDER, Cipro, Clostridium, complementary, complying, computed, confirmed, constituted, custom, cytoplasmic, earliest, education, enzyme, evolution, examine, explore, forming, gatifloxacin, ideal, Italia, jointly, Ketek, ketolide, lesser, Levaquin, microbiological, mode, moving, Nalidixic, nonaffiliated, opportunity, organism, outplacement, Pasteur, PathoGenomeTM, pharmacokinetic, privately, protein, PRSP, PTO, Quotation, ready, reexamination, reexamined, regimen, Squibb, structural, substance, suffering, suppression, Tequin, ticker, tid, tolerated, track, unamortized, unmet, unusual, upfront, utilizing, vacant, Zithromax
Filing tables
Filing exhibits
- 10-K Annual report
- 3.1 Articles of Organization
- 4.12 Form of Common Stock Purchase Warrant
- 4.13 Registration Rights Agreement
- 10.5 Lease Relating to Certain Property In Waltham, Ma
- 10.43 Amendment No. 7 to License & Option Agreement with LG Life Sciences, LTD.
- 10.44 License, Supply Marketing Agreement with Menarini Int'l Operation Luxembourg
- 12.1 Statement Re: Computation of Ratios
- 21.1 Subsidiaries of the Registrant
- 23.1 Consent of Ernst & Young LLP
- 31.1 Consent of Chief Executive Officer Pursuant to Section 302
- 31.2 Consent of Chief Financial Officer Pursuant to Section 302
- 32.1 Consent of Chief Executive Officer Pursuant to Section 906
- 32.2 Consent of Chief Financial Officer Pursuant to Section 906
Related press release
OSCI similar filings
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Exhibit 12.1
COMPUTATION OF RATIO OF EARNINGS TO FIXED CHARGES
(in thousands)
For the Year Ended December 31, | ||||||||||||||||||||
2006 | 2005 | 2004 | 2003 | 2002 | ||||||||||||||||
Earnings (loss)— | ||||||||||||||||||||
Loss before income taxes | $ | (78,298 | ) | $ | (88,593 | ) | $ | (93,271 | ) | $ | (29,789 | ) | $ | (34,017 | ) | |||||
Add fixed charges: | ||||||||||||||||||||
Interest expense on indebtedness | 9,574 | 6,557 | 4,480 | 990 | 1,936 | |||||||||||||||
Estimated interest on rental expense | 3,979 | 3,900 | 1,611 | 300 | 329 | |||||||||||||||
Amortization of deferred closing costs related to convertible notes | 827 | 816 | 521 | 156 | 294 | |||||||||||||||
Amortization of discount on convertible notes | — | — | — | 271 | 511 | |||||||||||||||
Total adjusted loss | $ | (63,918 | ) | $ | (77,320 | ) | $ | (86,659 | ) | $ | (28,072 | ) | $ | (30,947 | ) | |||||
Fixed charges— | ||||||||||||||||||||
Interest expense on indebtedness | $ | 9,574 | $ | 6,557 | $ | 4,480 | $ | 990 | $ | 1,936 | ||||||||||
Estimated interest on rental expense | 3,979 | 3,900 | 1,611 | 300 | 329 | |||||||||||||||
Amortization of deferred closing costs related to convertible notes | 827 | 816 | 521 | 156 | 294 | |||||||||||||||
Amortization of discount on convertible notes | — | — | — | 271 | 511 | |||||||||||||||
Total fixed charges | $ | 14,380 | $ | 11,273 | $ | 6,612 | $ | 1,717 | $ | 3,070 | ||||||||||
Coverage deficiency | $ | (78,298 | ) | $ | (88,593 | ) | $ | (93,271 | ) | $ | (29,789 | ) | $ | (34,017 | ) | |||||