First Mid Bancshares (FMBH) 10-Q 2022 Q2 Quarterly report

Exhibit 32.2

Certification pursuantto 18 U.S.C. section 1350, as adopted pursuantto

In connection with the Quarterly Report of First Mid Bancshares, Inc. (the “Company”) on Form 10-Q for the period ended June 30, 2022 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Matthew K. Smith, ChiefFinancialOfficeroftheCompany,certify,pursuantto18U.S.C.§1350,asadoptedpursuantto§906oftheSarbanes-Oxley Act of 2002,that:

(1) TheReportfullycomplieswiththerequirementsofsection13(a)or15(d)oftheSecuritiesExchangeActof1934; and

(2) TheinformationcontainedintheReportfairlypresents,inallmaterialrespects,thefinancialconditionandresults of operations of theCompany.

Date: August 8, 2022

/s/ Matthew K. Smith

Matthew K. Smith

Chief Financial Officer