Safeguard Scientifics (SFES) 8-K Safeguard Executes Game Plan, Announces Profit for 2006, Generates 31% Increase In Fourth Quarter 2006 Revenues

EXHIBIT 99.1

FOR IMMEDIATE RELEASE

CONTACT:
John E. Shave
Vice President, Investor Relations and Corporate Communications
610.293.0600

SAFEGUARD EXECUTES GAME PLAN, ANNOUNCES PROFIT FOR 2006,
GENERATES 31% INCREASE IN FOURTH QUARTER 2006 REVENUES

Well-Timed Exits, Ignited Deal Machinery, Augmented Organization
Generate Momentum for 2007

Wayne, PA, March 8, 2007 —Safeguard Scientifics, Inc. (NYSE: SFE), which builds value in growth-stage technology and life sciences companies, today announced its financial results for the fourth quarter and year-end 2006. In 2006, Safeguard executed upon its game plan to reposition itself as a holding company, to time exits for maximum risk-adjusted value, to ignite its deal machinery and to augment its organization. Through the sale of its holdings in Mantas and Traffic.com, Safeguard realized profitability for 2006, positioning the company to be able to deploy capital and continue to build value in its partner companies.

Safeguard reported consolidated revenues of $53.3 million for the fourth quarter of 2006, a 31% increase as compared to $40.7 million in 2005, adjusted for discontinued operations. This revenue growth represents the fifth consecutive quarter of double-digit revenue growth for Safeguard. For the full year, revenue was $198.1 million, up 38% from $143.8 million in 2005. Safeguard’s consolidated net income for the fourth quarter of 2006 was $71.3 million, compared to $2.3 million in 2005. For the full year, net income was $46.0 million, compared to a net loss of $32.1 million in 2005.

“In 2006, we made significant strides toward executing upon our game plan. As a holding company, we ignited our deal machinery, identified opportunities and deployed capital in seven transactions,” said Peter J. Boni, President and Chief Executive Officer of Safeguard. “Three of our new partners are technology-focused companies, Authentium, Portico Systems and Advantedge Healthcare Solutions; two are life sciences companies, Rubicor Medical and NuPathe. We also provided additional funding to support growth and product development at Acsis, while deploying additional capital and operational support for strategic acquisitions by Alliance Consulting and Clarient.”

Boni continued, “Throughout the year, we built value in our partner companies. We augmented our Safeguard team, both internally and externally, with two advisory boards, together with key board-level and management additions, although we are searching for a permanent CFO. We also realized value from divesting some of our partner company holdings during 2006, which drove us to profitability for the fourth quarter and full year.”

“Our successes in 2006 have established a foundation to support the transition into the second phase of our strategy. In 2007, we are focused on deploying capital, including the recently announced growth financing for Advanced BioHealing, Inc., a leader in regenerative medicine focused on the development and marketing of cell-based and tissue-engineered products. In addition, we’re looking to build value in our holdings and realize that value in selective, well-timed exits, ultimately driving shareholder value,” concluded Boni.

Safeguard Scientifics, Inc. | 435 Devon Park Drive, Building 800 | Wayne, PA 19087-1945 | T 610 293 0600 F 610 293 0601 | www.safeguard.com 1 

TECHNOLOGY PARTNER COMPANIES
Fourth Quarter Highlights — Majority Holdings

Acsis, Inc.extended its software solution within supply-chain management, growing its customer base 17% in 2006. Revenue for the fourth quarter was $5.5 million. In the fourth quarter, Acsis booked its strongest number of software licenses. Demand for its Acsis Line Manager was especially strong with over seventy stations sold. Throughout the year, Acsis focused its product development on emerging software markets, expanded strategic partnerships and built a world-class management team. Acsis re-architected its product portfolio and expects its expanding relationship with SAP^® to help drive new business opportunities in 2007.

Alliance Consulting, Inc.posted $1.0 million of operating income in the fourth quarter.Revenue for the fourth quarter increased to $26.0 million, up 8% as compared to 2005. Alliance’s year-over-year revenue growth far exceeded industry averages and its investment in growth areas such as Master Data Management has generated positive recognition by several industry analyst groups. Strong bookings in the fourth quarter enabled Alliance to start 2007 with solid backlog levels.

Pacific Title & Art Studio, Inc.was honored with an Academy Award for their innovative and proprietary digital archiving technology. In the fourth quarter, Pacific Title’s revenue was $6.8 million, a decrease of 4% year-over-year. This is reflective of an overall decline in the movie production industry.

LIFE SCIENCES PARTNER COMPANIES
Fourth Quarter Highlights — Majority Holdings

Laureate Pharma, Inc.achieved record growth in 2006 with fourteen new client agreements and a twofold increase in backlog as compared to 2005. Fourth quarter revenue was up more than 200% year-over-year at $4.9 million. The company increased its workforce more than 25%, is on track to complete its facility expansion, and entered into key strategic alliances during the year. In addition, Laureate Pharma formed a Scientific Advisory Board comprised of well-respected industry leaders to help guide the company through its evaluation of new services and emerging technologies.

Clarient, Inc. (Nasdaq: CLRT)reported significant growth in advanced cancer diagnostic services with decreasing losses. Revenue for the fourth quarter was $10.2 million, up 70% year-over-year. During the fourth quarter, Clarient reported that they have started realizing revenue from sales of their new Advanced Cellular Imaging System (ACIS^® III) and received milestone payments for their development efforts.

SAFEGUARD SCIENTIFICS FOURTH QUARTER AND YEAR-END 2006 EARNINGS CALL

Please call at least 10 minutes prior to call to register.

Date: Thursday, March 8, 2007

Start Time: 9:00am ET

Webcast: www.safeguard.com

Safeguard Scientifics, Inc. | 435 Devon Park Drive, Building 800 | Wayne, PA 19087-1945 | T 610 293 0600 F 610 293 0601 | www.safeguard.com 2 

Call-in Number: 1-877-407-0782
(International) +201-689-8567

Replay Number: 1-877-660-6853
(International) +201-612-7415

Replay Access Codes: Account# 286 — Conference ID# 231446

Both access codes are required for playback. Replay available through March 22, 2007 at 11:59pm ET.

Podcast:www.safeguard.com
Available after 2:00pm ET

Speakers: President and CEO Peter J. Boni, Acting CFO Stephen Zarrilli

Format: Discussion of fourth quarter and year end 2006 financial results followed by Q&A.

About Safeguard

Safeguard Scientifics, Inc. (NYSE: SFE) builds value in growth-stage technology and life sciences businesses. We provide growth capital as well as a range of strategic, operational and management resources to our partner companies. Safeguard participates in expansion financings, corporate spin-outs, management buyouts, recapitalizations, industry consolidations and early-stage financings. www.safeguard.com.

Forward-Looking and Cautionary Statements
Except for the historical information and discussions contained herein, statements contained in this release may constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Our forward-looking statements are subject to risks and uncertainties. These forward-looking statements that could cause actual results to differ materially, include, among others, managing rapidly changing technologies, limited access to capital, competition, the ability to attract and retain qualified employees, the ability to execute our strategy, the uncertainty of the future performance of our companies, acquisitions and dispositions of companies, the inability to manage growth, compliance with government regulations, additional financing requirements, labor disputes, the effect of economic conditions in the business sectors in which our companies operate, and other uncertainties described in the Company’s filings with the Securities and Exchange Commission, including our Annual Report on Form 10-K. Many of these factors are beyond our ability to predict or control. In addition, as a result of these and other factors, our past financial performance should not be relied on as an indication of future performance. The Company does not assume any obligation to update any forward-looking statements or other information contained in this press release.

[financials to follow after page break]

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Safeguard Scientifics, Inc. | 435 Devon Park Drive, Building 800 | Wayne, PA 19087-1945 | T 610 293 0600 F 610 293 0601 | www.safeguard.com 3 

Safeguard Scientifics, Inc.
Condensed Consolidated Balance Sheets
(in thousands)

	December 31,		December 31,
	2006		2005
Assets
Cash and cash equivalents and marketable securities — Parent	$	154,088	$	141,168
Cash and cash equivalents and marketable securities - Subsidiaries		11,318		16,616
Other current assets		49,580		50,309
Current assets of discontinued operations		—		12,263
Total current assets		214,986		220,356
Ownership interests in and advances to companies		54,548		17,897
Goodwill and intangible assets, net		98,924		93,284
Other		74,923		56,070
Non-current assets of discontinued operations		—		28,695
Total Assets	$	443,381	$	416,302
Liabilities and Shareholders’ Equity
Lines of credit	$	25,014	$	13,023
Other current liabilities		53,078		49,074
Current liabilities of discontinued operations		—		12,718
Total current liabilities		78,092		74,815
Other long-term liabilities		22,387		30,556
Convertible senior debentures		129,000		145,000
Non-current liabilities of discontinued operations		—		956
Redeemable stock-based compensation		2,021		—
Total shareholders’ equity		211,881		164,975
Total Liabilities and Shareholders’ Equity	$	443,381	$	416,302

Certain prior year amounts have been reclassified to conform to the current year presentation.

Safeguard Scientifics, Inc.
Condensed Consolidated Statements of Operations
(in thousands except per share amounts)

	Three Months Ended December 31,						Twelve Months Ended December 31,
	2006			2005			2006			2005
Revenue	$	53,342		$	40,688		$	198,060		$	143,831
Operating expenses		67,144			54,822			252,742			187,703
Operating loss		(13,802	)		(14,134	)		(54,682	)		(43,872	)
Other income, net interest, equity loss and minority interest		1,943			6,116			9,879			5,681
Net loss from continuing operations before income taxes		(11,859	)		(8,018	)		(44,803	)		(38,191	)
Income tax (expense) benefit		(117	)		81			1,023			83
Net loss from continuing operations		(11,976	)		(7,937	)		(43,780	)		(38,108	)
Income from discontinued operations, net of income taxes		83,300			10,279			89,810			6,038
Net income (loss)	$	71,324		$	2,342		$	46,030		$	(32,070	)
Basic and diluted net income (loss) per share:
Loss from continuing operations	$	(0.10	)	$	(0.07	)	$	(0.36	)	$	(0.32	)
Net income from discontinued operations		0.69			0.09			0.74			0.05
Net income (loss) per share	$	0.59		$	0.02		$	0.38		$	(0.27	)
Weighted average shares outstanding
Basic and Diluted		121,581			121,047			121,476			120,845

Safeguard Scientifics, Inc.
Results of Segment Operations from Continuing Operations
(in thousands)

	Three Months Ended December 31,						Twelve Months Ended December 31,
	2006			2005			2006			2005
Revenues
Acsis (e)	$	5,493		$	2,022		$	18,634		$	2,022
Alliance Consulting		25,964			24,026			104,571			82,604
Clarient		10,237			6,028			33,605			20,150
Laureate Pharma		4,850			1,558			11,714			7,709
Pacific Title and Art Studio		6,798			7,054			29,536			31,346
Total Segment Results	$	53,342		$	40,688		$	198,060		$	143,831
Operating Income (Loss) from Continuing Operations (a)
Acsis (e)	$	(2,120	)	$	(2,579	)	$	(8,776	)	$	(2,579	)
Alliance Consulting		1,006			643			808			(422	)
Clarient		(3,080	)		(4,059	)		(15,607	)		(15,981	)
Laureate Pharma		(1,672	)		(3,063	)		(9,129	)		(10,471	)
Pacific Title and Art Studio		416			(187	)		2,368			3,644
Total Segment Results		(5,450	)		(9,245	)		(30,336	)		(25,809	)
Other Items (d)		(8,352	)		(4,889	)		(24,346	)		(18,063	)
	$	(13,802	)	$	(14,134	)	$	(54,682	)	$	(43,872	)
Safeguard Share of Net Income (Loss) from Continuing Operations (b)
Acsis (e)	$	(2,001	)	$	(2,556	)	$	(8,264	)	$	(2,556	)
Alliance Consulting		881			432			127			(1,194	)
Clarient		(2,013	)		(2,476	)		(9,587	)		(9,717	)
Laureate Pharma		(1,857	)		(3,207	)		(9,737	)		(10,870	)
Pacific Title and Art Studio		433			(294	)		2,384			3,748
Other Companies (c)		(660	)		4,410			(2,455	)		(791	)
Total Segment Results		(5,217	)		(3,691	)		(27,532	)		(21,380	)
Other Items (d)		(6,759	)		(4,246	)		(16,248	)		(16,728	)
Net Loss from Continuing Operations	$	(11,976	)	$	(7,937	)	$	(43,780	)	$	(38,108	)

(a) Operating Income (Loss) from Continuing Operations represents the revenues less operating expenses of each segment, and excludes any allocation to minority interest.

(b) Safeguard Share of Net Income (Loss) from Continuing Operations includes the net results of each segment, including interest, adjusted for any amount allocated to minority interest.

(c) Other Companies includes those companies in which Safeguard has less than a majority interest, as well as our ownership in funds. Our share of Other Companies consists primarily of equity income (loss) and gains (loss) on companies, both of which are reported below the operating income (loss) line.

(d) Other Items includes corporate expenses and income taxes.

(e) Results for the year ended December 31, 2005 include only the period from acquisition (December 2, 2005) through December 31, 2005.

Safeguard Scientifics, Inc.
Partner Company Financial Data
(in thousands)

Additional Financial Information

To assist investors in understanding Safeguard and the value of our partner companies, we are providing additional financial information on our partner companies, including carrying value by majority partner company, as well as aggregate cost and carrying value for all of our minority partner companies and other holdings. The carrying value and cost data reflect our percentage holdings in the partner companies.

	December 31,
	2006
Safeguard Carrying Value by Majority Partner Company
Acsis	$	21,797
Alliance Consulting		63,021
Clarient		11,680
Laureate Pharma		9,511
Pacific Title and Art Studio		17,852
	$	123,861

	Carrying Value		Cost
Safeguard Cost and Carrying Value
Minority Partner Companies	$	43,777	$	102,643
Other holdings		10,771		36,393
	$	54,548	$	139,036