Vertex Pharmaceuticals (VRTX) 10-K2006 FY Annual report

Filed: 1 Mar 07, 12:00am

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New words: abroad, abuse, Achillion, Acorda, adalimumab, affordable, antibiotic, Antimicrobial, arm, artificial, avoid, back, behavior, BigBand, Black, bore, carefully, carryforward, Catalyst, certolizumab, CF, chance, choice, chosen, CMC, CML, colorectal, commensurate, cure, cytogenetic, deduction, derecognition, derecognize, developmental, device, Dickinson, dividend, easily, encouraging, endeavor, energy, enterprise, Epix, Erie, excellent, extracellular, fall, Farleigh, flux, footnote, forfeited, forfeiture, franchise, fraud, fraudulent, GPCR, great, GS, hair, headcount, HEAVILY, hemotological, Humira, hypothetically, ICAAC, illegal, immigration, implied, Incyte, infusion, ingredient, inside, Insider, instability, interface, InterMune, Interscience, Janssen, Kaletra, knowingly, lapsing, League, leukemic, leverage, Leveraging, line, lopinavir, lost, lymphocytic, mouth, MRSA, multicenter, MVM, myeloproliferative, nausea, network, Notwithstanding, nucleotide, orphan, Ph, Pharmaceutica, Philadelphia, pivotal, potassium, preceding, Preston, proportionately, QTc, quanosine, rare, rebound, recipient, recruiting, referral, Reg, repay, requisite, Reyataz, Rheumatism, safer, SCH, shorter, solicit, stored, stratify, subscription, SVR, telaprevir, terrorism, Tezir, threshold, Tibotec, tiered, timeframe, trailing, transduce, transplant, transplantation, travelling, triphosphate, UCB, unnecessary, unrecognized, unrest, ViroPharma, war, willingly, Wyeth, yield

Removed: ACR, age, al, AML, andin, assist, assumption, attention, attorney, Blair, book, booked, breached, Brum, cartilage, central, chemically, closed, conclude, constantly, construction, conveyed, County, credited, cytokine, deemed, Deutschland, devoted, DIG, diligence, disorder, dual, duty, Electron, enforcement, eventual, Feinstein, fiduciary, financially, found, GmbH, Graph, green, heading, Hill, Hoechst, identifiable, IIa, implementation, includein, Jeffrey, Kean, lactamase, load, LP, Lynne, Marion, mediate, negligently, noin, nonqualified, obligated, operationally, page, perception, pooling, PositionJoshua, powerful, predicted, preferable, professional, purported, reclassification, referenced, reflective, repayment, reporter, retroactive, revise, Roussel, Sacchetti, Schering, Schmidt, settled, Singapore, spent, strictly, suit, Sustiva, Telegraph, Thomson, turnover, undiscounted, urine, vigorously, Viread, Wellesley, wholly, Wilson, Ziagen

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EXHIBIT 21

SUBSIDIARIES OF VERTEX PHARMACEUTICALS INCORPORATED

Vertex Pharmaceuticals (San Diego) LLC, a Delaware limited liability company

VSD Sub I LLC, a Delaware limited liability company(1)

VSD Sub II LLC, a Delaware limited liability company(2)

Vertex Securities Corporation, a Massachusetts corporation

Vertex Pharmaceuticals (Cayman) Limited, a Cayman Islands company

Vertex Holdings, Inc., a Delaware corporation

Vertex Securities Trust, a Massachusetts business trust(3)

Vertex Pharmaceuticals (Europe) Ltd., a United Kingdom limited liability company(4)

(1) a subsidiary of Vertex Pharmaceuticals (San Diego) LLC

(2) a subsidiary of VSD Sub I LLC

(3) a subsidiary of Vertex Holdings, Inc.

(4) jointly held by Vertex Securities Trust and Vertex Holdings, Inc.