Exhibit 99.1

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From: | | David R. Harvey, Chairman, | | | | For questions contact: |
| | Jai P. Nagarkatti, President & CEO | | | | Kirk A. Richter, Treasurer |
| | | | | | (314) 286-8004 |
FOR IMMEDIATE RELEASE
August 14, 2007
SIGMA-ALDRICH (NASDAQ:SIAL) DECLARES QUARTERLY DIVIDEND
At the Board of Directors meeting held today, the Directors declared a quarterly cash dividend of $.115 per share. The dividend is payable on September 14, 2007 to shareholders of record on August 31, 2007.
About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing. We have customers in life science companies, university and government institutions, hospitals and in industry. Over one million scientists and technologists use our products. Sigma-Aldrich operates in 36 countries and has 7,700 employees providing excellent service worldwide. We are committed to accelerating our Customers’ success through leadership in Life Science, High Technology and Service. For more information about Sigma-Aldrich, please visit our award-winning web site atwww.sigma-aldrich.com