EXHIBIT 21
LIST OF SUBSIDIARIES
Subsidiary/undertaking | Jurisdiction of incorporation |
Advanced BioHealing Corp | United States |
Auralis Limited | United Kingdom |
Bikam Pharmaceuticals, Inc. | United States |
DuoCort Pharma AB | Sweden |
Farboud Pty Ltd | Australia |
FerroKin BioSciences, Inc. | United States |
Fibrotech Therapeutics Pty Ltd | Australia |
Jerini Ophthalmic Holding GmbH | Germany |
Jerini Ophthalmic, Inc | United States |
JPT Peptide Technologies Inc | United States |
Lotus Tissue Repair Inc | United States |
Lumena Pharma UK Limited | United Kingdom |
Lumena Pharmaceuticals LLC | United States |
Monmouth Pharmaceuticals Limited | United Kingdom |
Movetis GmbH | Germany |
Movetis Limited | United Kingdom |
Pharma International Insurance Limited | Ireland |
Premacure AB | Sweden and Luxembourg |
Premacure Uppsala AB | Sweden |
Rybar Laboratories Limited | United Kingdom |
SARcode Bioscience Inc. | United States |
SHGT Executive Services Inc. | United States |
Shire (Shanghai) Pharmaceuticals Consultancy Co., Ltd. | China |
Shire 2005 Investments Limited | Cayman Islands |
Shire Acquisitions UK Limited | United Kingdom |
Shire Australia Pty Limited | Australia |
Shire Belgium BVBA | Belgium |
Shire Biopharmaceuticals Holdings | United Kingdom |
Shire Biopharmaceuticals Holdings Ireland Limited | Jersey |
Shire Biopharmaceuticals Ireland Limited | Ireland |
Shire Brandywine LLC | United States |
Shire Pharma Canada ULC | Canada |
Shire Central & Eastern Europe GmbH | Germany |
Shire Colombia S.A.S | Colombia |
Shire Czech S.R.O. | Czech Republic |
Shire Denmark ApS | Denmark |
Shire Deutschland GmbH | Germany |
Shire Deutschland Investments GmbH | Germany |
Shire Development LLC | United States |
Shire Europe Finance | United Kingdom |
Shire Europe Limited | United Kingdom |
Shire Executive Services LLC | United States |
Shire Farmacêutica Brasil LTDA | Brazil |
Shire Finance Limited | Cayman Islands |
Shire Finland Oy | Finland |
Shire France S.A. | France |
Shire Global Finance | United Kingdom |
Shire Hellas Pharmaceuticals Import Export and Marketing S.A. | Greece |
Shire Holdings Europe B.V. | Netherlands |
Shire Holdings Europe Limited | United Kingdom |
Shire Holdings Europe No.2 S.a.r.l. | Luxembourg |
Shire Holdings Ireland | Ireland |
Shire Holdings Ireland No.2 Limited | Ireland |
Shire Holdings Limited | Bermuda |
Shire Holdings Luxembourg S.a r.l. | Luxembourg |
Shire Holdings UK Canada Limited | United Kingdom |
Shire Holdings UK Limited | United Kingdom |
Shire Holdings US AG | United States |
Shire Human Genetic Therapies (Canada) Inc. | Canada |
Shire Human Genetic Therapies AB | Sweden |
Shire Human Genetic Therapies Limited | United Kingdom |
Shire Human Genetic Therapies S.A. | Argentina |
Shire Human Genetic Therapies Securities Corporation | United States |
Shire Human Genetic Therapies UK Limited | United Kingdom |
Shire Human Genetic Therapies, Inc | United States |
SHIRE ILAC TICARET LIMITED SIRKETI / Shire Pharmaceuticals Trading Limited Company | Turkey |
Shire Incorporated | United States |
Shire Intellectual Property 2 SRL | Barbados |
Shire Intellectual Property Ireland Limited | Ireland |
Shire Intellectual Property SRL | Barbados |
Shire International GmbH | Switzerland |
Shire International Licensing BV | Netherlands |
Shire International Licensing VOF | Netherlands |
Shire Investments & Finance (U.K.) Company | United Kingdom |
Shire IP Services Corporation | Canada |
Shire Ireland Finance Limited | Ireland |
Shire Ireland Investment Limited | Ireland |
Shire Ireland Premacure Investment | Ireland |
Shire Italia S.p.A. | Italy |
Shire Japan KK | Japan |
Shire Jersey Limited | Jersey |
Shire LLC | United States |
Shire Luxembourg Finance S.a.r.l. | Luxembourg |
Shire Luxembourg Intellectual Property No.2 S.a r.l. | Luxembourg |
Shire Luxembourg Intellectual Property No.3 S.a.r.l. | Luxembourg |
Shire Luxembourg Intellectual Property S.a r.l. | Luxembourg |
Shire Luxembourg Sarl | Luxembourg |
Shire North American Group Inc. | United States |
Shire Norway AS | Norway |
Shire Orphan and Rare Diseases GmbH | Switzerland |
Shire Orphan Therapies GmbH | Germany |
Shire Orphan Therapies, Inc. | United States |
Shire Pharma Korea Yuhan Hoesa | Korea, Republic of |
Shire Pharmaceutical Contracts Limited | United Kingdom |
Shire Pharmaceutical Development Inc | United States |
Shire Pharmaceutical Development Limited | United Kingdom |
Shire Pharmaceutical Holdings Ireland Limited | Ireland |
Shire Pharmaceutical Investment Trading Ireland | Ireland |
Shire Pharmaceutical Investments 2008 | Ireland |
Shire Pharmaceuticals Group | United Kingdom |
Shire Pharmaceuticals Iberica S.L. | Spain |
Shire Pharmaceuticals International | Ireland |
Shire Pharmaceuticals Investments (British Virgin Islands) Limited | Virgin Islands, British |
Shire Pharmaceuticals Investments 2007 | Ireland |
Shire Pharmaceuticals Ireland Limited | Ireland |
Shire Pharmaceuticals Limited | United Kingdom |
Shire Pharmaceuticals LLC | United States |
Shire Pharmaceuticals Mexico SA de CV | Mexico |
Shire Pharmaceuticals Portugal, Lda | Portugal |
Shire Pharmaceuticals Services Limited | United Kingdom |
Shire Polska Sp. z o. o. | Poland |
Shire Properties US | United States |
Shire Regenerative Medicine LLC | United States |
Shire Regulatory Inc | United States |
Shire Rus Limited Liability Company | Russian Federation |
Shire Singapore Pte. Ltd. | Singapore |
Shire Supplies U.S. LLC | United States |
Shire Sweden AB | Sweden |
Shire Sweden Holdings S.a.r.l | Luxembourg |
Shire UK Investments Limited | United Kingdom |
Shire US Holdings LLC | United States |
Shire US Inc | United States |
Shire US Investment Inc | United States |
Shire US Investments | United Kingdom |
Shire US Manufacturing Inc | United States |
Shire ViroPharma Incorporated | United States |
Shire-Movetis NV | Belgium |
Sparkleflame Limited | United Kingdom |
Tanaud International BV | Netherlands |
Tanaud Ireland Inc. | Ireland |
The Endocrine Centre Limited | United Kingdom |
VCO Incorporated | United States |
ViroPharma AB | Sweden |
Viropharma Biologics Inc | United States |
Viropharma Canada Incorporated | Canada |
Viropharma GmbH | Germany |
Viropharma Holdings Limited | Bermuda |
Viropharma Holdings LLC | United States |
Viropharma Limited | United Kingdom |
ViroPharma LLC | Switzerland |
Viropharma Pty Ltd | Australia |
Viropharma Puerto Rico Inc | Puerto Rico |
Viropharma S.r.l | Italy |
Viropharma SAS | France |
Viropharma Spain SL | Spain |
Viropharma SPRL | Belgium |
Viropharma Sweden AB | Sweden |
VPDE Incorporated | United States |
VPINT Incorporated | United States |
VPMP Incorporated | United States |
All subsidiary undertakings of Shire plc are beneficially owned (directly or indirectly) as to 100% and are all consolidated in the consolidated financial statements of Shire plc.