| COVER PAGE COVER PAGE | Aug. 04, 2022 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Document Period End Date | Aug. 04, 2022 |
| Entity Registrant Name | OPKO Health, Inc. |
| Entity Incorporation, State or Country Code | DE |
| Entity File Number | 001-33528 |
| Entity Tax Identification Number | 75-2402409 |
| Entity Address, Address Line One | 4400 Biscayne Blvd. |
| Entity Address, City or Town | Miami, |
| Entity Address, State or Province | FL |
| Entity Address, Postal Zip Code | 33137 |
| City Area Code | 305 |
| Local Phone Number | 575-4100 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Entity Emerging Growth Company | false |
| Title of 12(b) Security | Common Stock, par value $0.01 per share |
| Trading Symbol | OPK |
| Security Exchange Name | NASDAQ |
| Entity Central Index Key | 0000944809 |
| Amendment Flag | false |
