Exhibit 31.1
I, Phillip Frost, certify that:
| (1) | I have reviewed this Annual Report on Form 10-K/A of OPKO Health, Inc.; and |
| (2) | Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report. |
| Date: April 29, 2013 | /s/ Dr. Phillip Frost, M.D. | |||||
| Dr. Phillip Frost, M.D. | ||||||
| Chief Executive Officer |
