190 patents
Page 10 of 10
Utility
Weekly dosing regimens for anti-CD30 vc-PAB-MMAE antibody drug-conjugates
18 Nov 19
Eric Sievers, Dana Kennedy
Filed: 3 Apr 19
Utility
Camptothecin Peptide Conjugates
13 Nov 19
Provided herein are Camptothecin Conjugates, Camptothecin-Linker Compounds, Camptothecin Compounds, intermediates thereof, and method of preparing the same.
Scott Jeffrey, Ryan Lyski, Maureen Ryan, Julia Cochran
Filed: 4 Apr 19
Utility
Targeted Pyrrolobenzodiazapine Conjugates
6 Nov 19
Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.
Philip Wilson Howard, Scott Jeffrey, Patrick Burke, Peter Senter
Filed: 10 Apr 19
Utility
Monomethylvaline Compounds Capable of Conjugation to Ligands
6 Nov 19
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB.
Svetlana O. DORONINA, Peter D. SENTER, Brian E. TOKI, Toni Beth KLINE
Filed: 9 Jul 19
Utility
Selective reduction of proteins
4 Nov 19
The present invention provides a method for making uncapped cysteine protein preparations, including uncapped engineered cysteine antibody preparations.
Damon L. Meyer
Filed: 10 Feb 15
Utility
Preparing antibodies from CHO cell cultures for conjugation
28 Oct 19
The invention is based in part on the observation that a CHO cell oxidizing enzyme, particularly QSOX1, can survive a seemingly rigorous antibody purification process to reduce subsequent conjugation efficiency of the antibody to a drug.
Kevin Beam, Damon Meyer, Bradley Hayes, Robert Lyon, John Valliere-Douglass
Filed: 20 Nov 14
Utility
Targeted Delivery of Nicotinamide Adenine Dinucleotide Salvage Pathway Inhibitors
16 Oct 19
Compounds and compositions are disclosed in which a NAMPT Drug Unit is linked to a targeting Ligand Unit through a Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action.
Christopher Scott Neumann, Kathleen Olivas
Filed: 17 Oct 17
Utility
Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
14 Oct 19
The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
Filed: 9 Oct 17
Utility
Detection and treatment of CD30
14 Oct 19
The application provides methods of diagnosis, prognosis, prophylasxis and treatment of CD30+ cancers.
Tina Albertson, Maria L. Smith
Filed: 7 Feb 13
Utility
Anti-NTB-A antibodies and related compositions and methods
7 Oct 19
Disclosed are antibodies, including antibody drug conjugates, that specifically bind to NTB-A.
Timothy S. Lewis, Che-Leung Law
Filed: 13 Jun 17