190 patents
Page 6 of 10
Utility
Methylene Carbamate Linkers for use with Targeted-Drug Conjugates
24 Feb 22
The present invention provides Ligand-Drug Conjugates and Drug-Linker Compounds comprising a methylene carbamate unit.
Robert Kolakowski, Scott Jeffrey, Patrick Burke
Filed: 2 Aug 21
Utility
Glycan-Interacting Compounds and Methods of Use
24 Feb 22
The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer.
Ana Paula Galvao da Silva, Darius Ghaderi, Mai Zhang, Kristan Meetze, Julie DeSander, Jeffrey Behrens, David A. Eavarone, Jillian M. Prendergast
Filed: 26 May 21
Utility
Glycan-interacting compounds and methods of use
22 Feb 22
Methods of treating cancer are provided that include administering glycan-interacting antibodies.
Daniel T. Dransfield, Jillian M. Prendergast, David A. Eavarone
Filed: 2 Mar 18
Utility
Adcs with Thiol Multiplex Linkers
10 Feb 22
The present disclosure provides, inter alia, thiol multiplexed Antibody Drug Conjugates (TM-ADCs) and Multiplex Linking Assemblies (MLAs) that comprise multiple Drug Moieties in a single linking assembly.
Scott Jeffrey, Kung-Pern Wang
Filed: 20 Dec 19
Utility
Bcma Antibodies and Use of Same to Treat Cancer and Immunological Disorders
27 Jan 22
The invention provides humanized antibodies that specifically bind to BCMA.
Django Sussman, Maureen Ryan, Lori Westendorf, Michael Feldhaus
Filed: 25 Jun 21
Utility
Bivalent antibodies masked by coiled coils
25 Jan 22
The invention provides bivalent antibodies including two light and heavy chain pairs.
Vivian Trang, Matthew R. Levengood, Peter Senter
Filed: 8 Dec 17
Utility
Conjugates of quaternized tubulysin compounds
25 Jan 22
Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action.
Patrick J. Burke, Joel Courter
Filed: 2 Dec 16
Utility
Dosage and administration of non-fucosylated anti-CD40 antibodies
4 Jan 22
This invention relates methods of using a non-fucosylated anti-CD40 antibody for treatment of cancer and chronic infectious diseases.
Shyra Gardai, Che-Leung Law, Stanford Peng, Jing Yang, Haley Neff-LaFord
Filed: 29 Oct 15
Utility
Treatment of HER2 positive cancers
28 Dec 21
In one aspect, the present invention provides a method for treating or ameliorating the effects of a HER2 positive cancer in a subject.
Scott Peterson, Luke Walker
Filed: 27 Apr 18
Utility
Dosage and administration of non-fucosylated anti-CD40 antibodies
21 Dec 21
This invention relates methods of using a non-fucosylated anti-CD40 antibody for treatment of cancer and chronic infectious diseases.
Shyra Gardai, Che-Leung Law, Stanford Peng, Jing Yang, Haley Neff-LaFord, Thomas John Manley
Filed: 20 Jan 17
Utility
Combinations of PBD-based antibody drug conjugates with FLT3 inhibitors
7 Dec 21
This invention relates to treatment of cancer using a antibody drug conjugates that comprise PBD molecules in combination with FLT3 inhibitors.
William Arthur, Travis Biechele, Rory Rohm, Robert Thurman
Filed: 8 Jun 17
Utility
Glypican 3 Antibodies and Conjugates Thereof
25 Nov 21
The invention provides murine, chimeric, and humanized antibodies that specifically bind to GPC3 and conjugates thereof.
Travis Biechele, William Arthur, Patrick Burke, Lori Westendorf
Filed: 15 Feb 19
Utility
CD47 antibodies and uses thereof for treating cancer
23 Nov 21
Humanized antibodies, including masked antibodies that specifically bind to CD47 are provided.
Shyra Gardai, Matthew Levengood, Vivian Trang, Lori Westendorf, Christopher Carosino, Che Leung-Law, Michael Feldhaus
Filed: 29 Nov 18
Utility
Intact mass determination of protein conjugated agent compounds
9 Nov 21
The present invention provides methods and systems for the rapid determination of the intact mass of non-covalently associated antibody heavy chains (HC) and light chains (LC) which result from the attachment of drug conjugates to interchain cysteine residues.
John Fay Valliere-Douglass, Oscar Salas
Filed: 19 Mar 18
Utility
Antibodies to Integrin AVB6 and Use of Same to Treat Cancer
4 Nov 21
The invention provides antibodies that specifically bind to integrin αvβ6.
Maureen Ryan, Django Sussman
Filed: 8 Jan 21
Utility
Weekly Dosing Regimens for ANTI-CD30 Vc-pab-mmae Antibody Drug-conjugates
14 Oct 21
Eric Sievers, Dana Kennedy
Filed: 25 Jun 21
Utility
Self-stabilizing Linker Conjugates
30 Sep 21
The present invention provides Ligand-Drug Conjugates, Drug-Linkers, Linkers, and Ligand-Linker Conjugates comprising a self-stabilizing linker assembly component.
Robert LYON, Svetlana O. DORONINA, Timothy BOVEE
Filed: 4 Dec 20
Utility
Antibody Drug Conjugates (Adc) That Bind to 191P4D12 Proteins
16 Sep 21
Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I.
Daulet SATPAYEV, Robert Kendall MORRISON, Karen Jane Meyrick MORRISON, Jean GUDAS, Aya JAKOBOVITS, Michael TORGOV, Zili AN
Filed: 15 Dec 20
Utility
Hydrophilic Antibody-drug Conjugates
16 Sep 21
Hydrophilic Linkers, Drug-Linker compounds, Drug-Ligand Conjugate compounds and Ligand-Linkers and methods of making and using the same are provided.
Svetlana DORONINA, Robert LYON, Peter SENTER
Filed: 27 Jan 21
Utility
Methylene carbamate linkers for use with targeted-drug conjugates
14 Sep 21
The present invention provides Ligand-Drug Conjugates and Drug-Linker Compounds comprising a methylene carbamate unit.
Robert Kolakowski, Scott Jeffrey, Patrick Burke
Filed: 19 Dec 14