394 patents
Page 4 of 20
Utility
Methods and compositions for addressing inefficiencies in amplification reactions
18 Jul 23
Methods and systems for decreasing amplification bias and primer-dimer formation in amplification reactions and for amplifying a plurality of target polynucleotides from a sample in a single reaction and for sequencing the target polynucleotides where samples can include forensic samples and where target polynucleotides can include identity- or ancestry-informative markers, short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs).
Jon-Matthew Belton, Johann Felix Schlesinger, Siarhei Manakou, Amanda Garfinkel Young
Filed: 13 Jun 18
Utility
Polymer coatings
18 Jul 23
The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells.
Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
Filed: 1 Mar 21
Utility
Self assembled patterning using patterned hydrophobic surfaces
18 Jul 23
Embodiments provided herewith are directed to self-assembled methods of preparing a patterned surface for sequencing applications including, for example, a patterned flow cell or a patterned surface for digital fluidic devices.
Yir-Shyuan Wu, Yan-You Lin, M. Shane Bowen, Cyril Delattre, Fabien Abeille, Tarun Khurana, Arnaud Rival, Poorya Sabounchi, Dajun Yuan, Maria Candelaria Rogert Bacigalupo
Filed: 5 May 22
Utility
Deep learning-based variant classifier
18 Jul 23
The technology disclosed directly operates on sequencing data and derives its own feature filters.
Ole Schulz-Trieglaff, Anthony James Cox, Kai-How Farh
Filed: 14 Jan 19
Utility
Systems, methods, and apparatuses to image a sample for biological or chemical analysis
11 Jul 23
A fluidic device holder configured to orient a fluidic device.
Erik Williamson, Bryan Crane, Patrick Leung, Drew Verkade, Mark T. Reed
Filed: 5 Apr 22
Utility
Super resolution imaging
11 Jul 23
A detection apparatus that includes (a) an array of responsive pads on a substrate surface; (b) an array of pixels, wherein each pixel in the array has a detection zone on the surface that includes a subset of at least two of the pads; and (c) an activation circuit to apply a force at a first and second pad in the subset, wherein the activation circuit is configured to apply a different force at the first pad compared to the second pad, and wherein the activation circuit has a switch to selectively alter the force at the first pad and the second pad.
Robert C. Kain, Tarun Khurana, Kevin L. Gunderson, Yir-Shyuan Wu
Filed: 1 Apr 20
Utility
Using non-redundant components to increase calculation efficiency for structured illumination microscopy
11 Jul 23
The technology disclosed present systems and methods to produce an enhanced resolution image from images of a target using structured illumination microscopy (SIM).
Robert Ezra Langlois, Andrew James Young, Andrew Dodge Heiberg, Bo Lu
Filed: 20 May 22
Utility
Flow cell with selective deposition or activation of nucleotides
4 Jul 23
An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly.
Ali Agah, Aathavan Karunakaran, Tarun Khurana, Stanley Hong, Merek Siu, Arvin Emadi, Craig Ciesla
Filed: 30 Aug 22
Utility
Equalizer-based intensity correction for base calling
4 Jul 23
The technology disclosed relates to equalizer-based intensity correction for base calling.
Eric Jon Ojard, Rami Mehio, Gavin Derek Parnaby, Nitin Udpa, John S. Vieceli
Filed: 9 Nov 21
Utility
Methylation markers and targeted methylation probe panel
27 Jun 23
The present description provides a cancer assay panel for targeted detection of cancer-specific methylation patterns.
Samuel S. Gross, Oliver Claude Venn, Seyedmehdi Shojaee, John Beausang, Arash Jamshidi
Filed: 26 Mar 21
Utility
Systems and methods for grouping and collapsing sequencing reads
27 Jun 23
Disclosed herein are systems and methods for collapsing sequencing reads and identifying similar sequencing reads.
Chen Zhao, Kevin Eric Wu, Sven Bilke
Filed: 29 Oct 19
Utility
Kinetic exclusion amplification of nucleic acid libraries
30 May 23
An example method includes reacting a first solution and a different, second solution on a flow cell by flowing the first solution over amplification sites on the flow cell and subsequently flowing the second solution over the amplification sites.
Shaun Hunter, Peter McInerney, Jonathan Boutell, Claire Bevis-Mott
Filed: 25 Sep 20
Utility
Methods and compositions for recombinase-mediated selective cleavage of nucleic acids
16 May 23
Embodiments of the methods and compositions provided herein relate to the selective cleavage of target nucleic acids.
Clifford Lee Wang
Filed: 15 Mar 19
Utility
Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells
16 May 23
Implementations of a method for seeding sequence libraries on a surface of a sequencing flow cell that allow for spatial segregation of the libraries on the surface are provided.
Tarun Kumar Khurana, Yir-Shyuan Wu, Xi-Jun Chen, Filiz Gorpe-Yasar, Yan-You Lin, Victoria Popic, Erich B. Jaeger, Mostafa Ronaghi
Filed: 13 Apr 22
Utility
Reduced dimensionality structured illumination microscopy with patterned arrays of nanowells
16 May 23
Techniques are described for reducing the number of angles needed in structured illumination imaging of biological samples through the use of patterned flowcells, where nanowells of the patterned flowcells are arranged in, e.g., a square array, or an asymmetrical array.
Gary Mark Skinner, Geraint Wyn Evans, Stanley S. Hong
Filed: 3 Aug 21
Utility
Conformational probes and methods for sequencing nucleic acids
9 May 23
This disclosure provides a method of determining a sequence of nucleotides for a nucleic acid template.
Molly He, Cheng-Yao Chen, Eric Kool, Mostafa Ronaghi, Michael Previte, Rigo Pantoja
Filed: 6 Nov 20
Utility
Enclosures and corresponding magnetic joints
9 May 23
Enclosures and corresponding magnetic joints.
Erik Allegoren
Filed: 1 Sep 21
Utility
System and method for secondary analysis of nucleotide sequencing data
9 May 23
Disclosed herein are systems and methods for performing secondary analyses of nucleotide sequencing data in a time-efficient manner.
Francisco Jose Garcia, Come Raczy, Aaron Day, Michael J. Carney
Filed: 6 Oct 17
Utility
Polymerases, compositions, and methods of use
25 Apr 23
Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
Kay Klausing, Hamed Tabatabaei Ghomi, Misha Golynskiy, Saurabh Nirantar, Seth McDonald, Sergio Peisajovich
Filed: 9 Apr 21
Utility
Methods and compositions for analyzing cellular components
25 Apr 23
Embodiments of the present invention relate to analyzing components of a cell.
Kevin L Gunderson, Frank J Steemers, Jeffrey S Fisher, Roberto Rigatti
Filed: 10 Feb 16