394 patents
Page 6 of 20
Utility
Inter-cluster intensity variation correction and base calling
28 Feb 23
The technology disclosed corrects inter-cluster intensity profile variation for improved base calling on a cluster-by-cluster basis.
Eric Jon Ojard, Abde Ali Hunaid Kagalwalla, Rami Mehio, Nitin Udpa, Gavin Derek Parnaby, John S. Vieceli
Filed: 24 May 22
Utility
Base calling using convolutions
28 Feb 23
We propose a neural network-based base caller that detects and accounts for stationary, kinetic, and mechanistic properties of the sequencing process, mapping what is observed at each sequence cycle in the assay data to the underlying sequence of nucleotides.
Emrah Kostem
Filed: 14 May 20
Utility
Library preparation and use thereof for sequencing based error correction and/or variant identification
21 Feb 23
Aspects of the invention include methods for preparing sequencing libraries, performing sequencing procedures that can correct for process-related errors, and identifying rare variants that are or may be indicative of cancer.
Arash Jamshidi, Gordon Cann, Hamed Amini, Alex Aravanis
Filed: 30 Mar 18
Utility
Device for luminescent imaging
21 Feb 23
A device includes a plurality of imaging pixels in a spatial pattern with a formation of features disposed over the pixels.
Dajun Yuan, Liangliang Qiang, Minghao Guo
Filed: 12 Jun 19
Utility
Flowcell cartridge with floating seal bracket
14 Feb 23
A cartridge for use with chemical or biological analysis systems is provided.
David Elliott Kaplan, Anthony John de Ruyter, Richard Alan Kelley, Ashish Kumar
Filed: 30 Jan 20
Utility
Charge-tagged nucleotides and methods of use thereof
14 Feb 23
Jeffrey Mandell, Silvia Gravina, Sergio Peisajovich, Kaitlin Pugliese, Yin Nah Teo, Xiangyuan Yang, Maria Candelaria Rogert Bacigalupo
Filed: 30 Nov 20
Utility
Photonic structure-based devices and compositions for use in luminescent imaging of multiple sites within a pixel, and methods of using the same
14 Feb 23
A device for luminescent imaging includes an array of imaging pixels, a photonic structure over the array of imaging pixels, and an array of features over the photonic structure.
Juraj Topolancik, Cheng Frank Zhong
Filed: 21 Apr 17
Utility
Systems and methods for classifying patients with respect to multiple cancer classes
14 Feb 23
Technical solutions for classifying patients with respect to multiple cancer classes are provided.
M. Cyrus Maher, Anton Valouev, Darya Filippova, Virgil Nicula, Karthik Jagadeesh, Oliver Claude Venn, Samuel S. Gross, John F. Beausang, Robert Abe Paine Calef
Filed: 10 Dec 19
Utility
Cartridge with laminated manifold
31 Jan 23
A circuit with electrical interconnect for external electronic connection and sensor(s) on a die are combined with a laminated manifold to deliver a liquid reagent over an active surface of the sensor(s).
Darren Segale, Hai Tran, Paul Crivelli
Filed: 6 Dec 19
Utility
Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
31 Jan 23
A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane.
Dale Buermann, John A. Moon, Bryan Crane, Mark Wang, Stanley S. Hong, Jason Harris, Matthew Hage, Mark J. Nibbe
Filed: 6 Jan 20
Utility
Methods of preparing dual-indexed DNA libraries for bisulfite conversion sequencing
31 Jan 23
Described herein are methods of preparing dual-indexed nucleic acid libraries for methylation profiling using bisulfite conversion sequencing.
Anton Valouev, Arash Jamshidi
Filed: 10 Aug 17
Utility
Nanopore sequencers
31 Jan 23
Example nanopore sequencers include a cis well, a trans well, and a nanopore fluidically connecting the cis and trans wells.
Boyan Boyanov, Rohan N. Akolkar, Jeffrey S. Fisher, Jeffrey G. Mandell, Liangliang Qiang, Steven M. Barnard
Filed: 19 Jun 18
Utility
Optical distortion correction for imaged samples
31 Jan 23
Techniques are described for dynamically correcting image distortion during imaging of a patterned sample having repeating spots.
Robert Langlois, Paul Belitz
Filed: 29 Jan 21
Utility
Systems and devices for high-throughput sequencing with semiconductor-based detection
24 Jan 23
In one embodiment, a sample surface of a biosensor includes pixel areas and holds a plurality of clusters during a sequence of sampling events such that the clusters are distributed unevenly over the pixel areas.
Dietrich Dehlinger, Ali Agah, Tracy Helen Fung, Emrah Kostem, Craig Hetherington
Filed: 7 Jan 19
Utility
Systems, methods, and apparatuses to image a sample for biological or chemical analysis
24 Jan 23
A fluidic device holder configured to orient a fluidic device.
Erik Williamson, Bryan Crane, Patrick Leung, Drew Verkade, Mark T. Reed
Filed: 23 Jan 19
Utility
Polymerases, compositions, and methods of use
24 Jan 23
Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
Misha Golynskiy, Seth McDonald, Saurabh Nirantar, Matthew Kellinger, Michael Previte, Sergio Peisajovich, Molly He
Filed: 9 Aug 21
Utility
Actuation systems and methods
17 Jan 23
Actuation systems and methods are disclosed.
Reto Schoch, Xuance Zhou, Tarun Khurana, Chetanya Jain, Gregory Suematsu
Filed: 17 Nov 21
Utility
Integrated consumer genomic services
17 Jan 23
The present invention provides a novel approach for consumer-driven interaction with sequencing data or genomic information.
Nicholas A. Nelson, Alexander G. Dickinson, Kenneth R. Bloom, Sophie I. Coon, Kenneth J. Sherman, Kenneth G. Yocum, Kevin P. Rhodes, Jerome O. Chadel, Matthew L. Posard
Filed: 23 Aug 19
Utility
Polynucleotide enrichment and amplification using CRISPR-Cas or Argonaute systems
3 Jan 23
A method for enriching or amplifying a target nucleic acid including providing a system having a guide nucleic acid, and a Cas or Argonaute protein or a variant thereof.
Jeffrey G. Mandell, Molly He
Filed: 10 May 17
Utility
Labeled nucleotides
3 Jan 23
A labeled nucleotide includes a nucleotide, a linking molecule attached to a phosphate group of the nucleotide, and a redox-active charge tag attached to the linking molecule.
Jeffrey Mandell, Steven Barnard, John Moon, Maria Candelaria Rogert Bacigalupo
Filed: 13 Feb 19