525 patents
Utility
Method of treating cancer by administering immune effector cells expressing a chimeric antigen receptor comprising a CD20 binding domain
16 Jan 24
The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22.
Barbara Brannetti, Jennifer Brogdon, Boris Engels, Brian Walter Granda, Lu Huang, Ming Lei, Na Li, Jimin Zhang, Carla Patricia Pinto Guimaraes, Saar Gill, Marco Ruella, Regina M. Young
Filed: 30 Apr 21
Utility
Manufacture of compounds and compositions for inhibiting the activity of SHP2
16 Jan 24
Zhongbo Fei, Huanqing Jia, Wei Li, Xiaohui Lin, Zhongcheng Min, Hui Wang, Jianhua Wang, Hao Zhang
Filed: 18 Sep 19
Utility
Formulations of (S)-3-amino-6-methoxy-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide
9 Jan 24
Provided herein are compounds and pharmaceutical compositions useful for treating bronchiectasis, chronic obstructive pulmonary disorder, cystic fibrosis, chronic bronchitis or asthma comprising administering to a subject in need thereof a therapeutically effective amount of a compound or pharmaceutical composition described herein.
Vivek Dubey, Rohit Lowalekar, Paulo G. Santos, Hubert Thoma, Xianbin Tian
Filed: 15 Jul 20
Utility
Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor
9 Jan 24
The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII.
Jennifer Brogdon, Laura Alexandra Johnson, Carl H. June, Andreas Loew, Marcela Maus, John Scholler, Hideho Okada
Filed: 12 Apr 19
Utility
Optimized lentiviral transfer vectors and uses thereof
9 Jan 24
The invention features lentiviral transfer vectors that include heterologous nucleic acids to be introduced into a cell.
Vladimir Slepushkin, Dmitriy Lukashev
Filed: 23 Nov 21
Utility
Humanization of rabbit antibodies using a universal antibody framework
2 Jan 24
The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework.
Leonardo Borras, David Urech
Filed: 18 Dec 17
Utility
Method for preparing granules
19 Dec 23
A method for preparing granules.
Markus Krumme, Hans De Waard, Klaus-Peter Moll, Adrian Schmidt, Julien Taillemite
Filed: 30 Aug 18
Utility
1,3-substituted cyclobutyl derivatives and uses thereof
19 Dec 23
Donglei Liu, Julien Papillon, Stefan Peukert, James J. Powers
Filed: 24 Mar 22
Utility
3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
5 Dec 23
Rohan Eric John Beckwith, Simone Bonazzi, Artiom Cernijenko, Fupeng Ma, Nathaniel F. Ware
Filed: 4 Oct 21
Utility
CKIT antibody drug conjugates
5 Dec 23
The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
Tinya Abrams, Steven Bruce Cohen, Dylan Daniel, Catrin Finner, Bernhard Hubert Geierstanger, Thomas Huber, William Mallet, Matthew John Meyer, Weijia Ou, Siew Ho Schleyer, Kathrin Ulrike Tissot-Daguette
Filed: 4 Jun 20
Utility
Method of treating structural and/or functional cardiac abnormalities by administering an anti-ActRII receptor antibody
5 Dec 23
The disclosure relates to novel uses and methods for preventing and/or treating heart disease, which employ a therapeutically effective amount of an ActRII receptor antagonist, e.g., an ActRII receptor binding molecule, e.g., an ActRII receptor antibody, such as the bimagrumab antibody.
Anthony Rosenzweig, Jason D. Roh, David J. Glass
Filed: 16 Mar 21
Utility
Antibody molecules to PD-1 and uses thereof
28 Nov 23
Antibody molecules that specifically bind to PD-1 are disclosed.
Gordon James Freeman, Arlene Helen Sharpe, Walter A. Blattler, Jennifer Marie Mataraza, Catherine Anne Sabatos-Peyton, Hwai Wen Chang, Gerhard Johann Frey
Filed: 10 Jul 20
Utility
Micro-droplet delivery device and methods
21 Nov 23
Micro-droplet delivery devices and methods are described where the device may comprise a piezoelectric actuator having a piezoelectric chip that is operatively coupled to a drug package under a preloading force.
Yehuda Ivri
Filed: 17 Apr 20
Utility
2-azaspiro[3.4]octane derivatives as M4 agonists
21 Nov 23
Amy Calhoun, Xin Chen, Kevin Matthew Gardinier, Edward Charles Hall, Keith Jendza, Nancy Labbe-Giguere, James Neef, Daniel Steven Palacios, Ming Qian, Michael David Shultz, Christopher G. Thomson, Kate Yaping Wang, Fan Yang
Filed: 8 Aug 22
Utility
Cyclic tetramer compounds as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders
14 Nov 23
Karin Briner, Brian Addison Dechristopher, Alec Nathanson Flyer, Andrei Alexandrovich Golosov, Philipp Grosche, Eugene Yuejin Liu, Justin Yik Ching Mao, Lauren Gilchrist Monovich, Tajesh Jayprakash Patel, Liansheng Su, Lihua Yang, Rui Zheng
Filed: 12 Mar 21
Utility
NMDA receptor modulators and uses thereof
7 Nov 23
Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder.
David R. Anderson, Robert Volkmann, Frank Menniti, Christopher Fanger, Yuelian Xu
Filed: 27 Jan 22
Utility
Selection vectors and methods of selecting eukaryotic host cells
7 Nov 23
The disclosure is directed to an expression vector or a combination of at least two expression vectors for producing a polypeptide of interest, the vector or vectors comprising a polynucleotide encoding a mutated folate receptor as a selectable marker.
Yehuda G Assaraf, Thomas Jostock, Hans-Peter Knopf
Filed: 29 Jul 14
Utility
Pharmaceutical products and stable liquid compositions of IL-17 antibodies
31 Oct 23
The disclosure is directed to pharmaceutical products and stable liquid compositions of IL-17 antibodies and antigen-binding fragments thereof, e.g., AIN457 (secukinumab), and processes of making these pharmaceutical products and compositions.
Susanne Joerg, Kathrin Serno-Schersch
Filed: 21 Dec 15
Utility
Methods of treating FGF21-associated disorders
31 Oct 23
The present invention relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human β-klotho, and pharmaceutical compositions and methods of treatment comprising the same.
Brian Boettcher, Shari Lynn Caplan, Regis Cebe, Guochun Li, John A. Taraszka, Fangmin Xu, David Langdon Yowe
Filed: 1 Dec 21
Utility
Sacubitril calcium salts
17 Oct 23
The invention relates to polymorphic forms of the calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester.
David Hook, Bin Hu, Florian Karl Kleinbeck, Ulrich Meier, Sibylle Mueller, Jean-Paul Mutz, Jan Schlomach, Paul Allen Sutton, Liladhar Murlidhar Waykole, Bernhard Wietfeld
Filed: 2 Jul 15