53 patents
Utility
Multiple Analyte Fecal Antigen Testing
18 Jan 24
Methods, compositions, and systems for testing fecal samples, including small human fecal samples, for a plurality of different marker analytes, e.g., a plurality of different human protein, nucleic acid, and other molecular marker analytes.
Keith D. Fourrier, Michael J. Domanico, Stephanie M. Weber, Tanya M. Quint, Graham P. Lidgard
Filed: 16 Oct 20
Utility
Detecting Prostate Cancer
28 Dec 23
Provided herein is technology for prostate cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of prostate cancer.
David A. Ahlquist, William R. Taylor, John B. Kisiel, Tracy C. Yab, Douglas W. Mahoney, Brian A. Dukek, Matthew T. Gettman, Hatim T. Allawi
Filed: 24 May 23
Utility
Methylation Assay
21 Dec 23
A method for detecting a methylated genomic locus is provided.
Graham P. Lidgard, Michael J. Domanico, Hatim Allawi, Hongzhi Zou
Filed: 12 May 23
Utility
Isolation and Detection of Dna from Plasma
7 Dec 23
Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA.
Hatim Allawi, Graham P. Lidgard, Brian Aizenstein, Tamara J. Sander, Maria Giakoumopoulos, Michael W. Kaiser, Melissa M. Gray, Abram Michael Vaccaro
Filed: 1 May 23
Utility
Synthetic Nucleic Acid Control Molecules
9 Nov 23
The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods.
Ilse A. Tyler, Keith Yaeger, Michael J. Domanico, Hatim Allawi, Graham P. Lidgard
Filed: 1 May 23
Utility
Fecal Sample Processing and Analysis Comprising Detection of Blood
5 Oct 23
A method of processing a fecal sample from a human subject comprising combining a first portion of a collected fecal sample with a stabilizing buffer, combining a second portion of the sample with a solution that prevents denaturation or degradation of blood proteins found in a fecal sample.
Joost Louwagie
Filed: 7 Mar 23
Utility
Fecal Sample Processing and Analysis Comprising Detection of Blood
31 Aug 23
A method of processing a fecal sample from a human subject comprising combining a first portion of a collected fecal sample with a stabilizing buffer that maintains DNA integrity in a fecal sample, and combining a second portion of the sample with a solution that prevents denaturation or degradation of blood proteins found in a fecal sample.
Joost Louwagie
Filed: 7 Mar 23
Utility
Method for Stabilizing Hemoglobin and Reagents for Performing the Same
13 Jul 23
A stool resuspension solution comprising a hemoglobin stabilization reagent is provided.
Keith D. Fourrier, Jacquelyn T. Hennek, Michael J. Domanico, William G. Weisburg, Graham P. Lidgard, Kathleen S. Harings, Daniel J. Simpson
Filed: 24 Jan 23
Utility
Detecting Melanoma
18 May 23
Provided herein is technology for primary cutaneous melanoma screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of primary cutaneous melanoma.
David A. Ahlquist, John B. Kisiel, William R. Taylor, Douglas W. Mahoney, Calise K. Berger, Hatim T. Allawi, Viatcheslav Katerov
Filed: 4 May 21
Utility
Detection of Lung Neoplasia by Amplification of Rna Sequences
20 Apr 23
Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.
Hatim Allawi, Graham P. Lidgard, Chateen Krueger, Michael W. Kaiser, Tamara J. Sander
Filed: 15 Sep 22
Utility
Fecal Sample Processing and Analysis Comprising Detection of Blood
16 Feb 23
A method of processing a fecal sample from a human subject comprising removing a portion of a collected fecal sample and adding the removed portion of the sample to a buffer that prevents denaturation or degradation of blood proteins found in the sample, and detecting the presence of human blood in the removed portion of the fecal sample.
Joost Louwagie
Filed: 28 Sep 22
Utility
Structure and Temperature-dependent Flap Endonuclease Substrates
16 Feb 23
5′ hairpin oligonucleotide substrates for reversible repression, e.g., by temperature shift, of cleavage by flap endonucleases, and methods using 5′ hairpin oligonucleotides.
Zubin Gagrat, Michael B. Matter, Nicholas J. Domanico, Michael J. Domanico
Filed: 16 Sep 20
Utility
Characterizing Methylated Dna, Rna, and Proteins In Subjects Suspected of Having Lung Neoplasia
22 Dec 22
Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as lung cancer.
Scott Morris, David Mallery, Hatim T. Allawi, Graham P. Lidgard, Maria Giakoumopoulos, Michael W. Kaiser, David A. Ahlquist, William R. Taylor, Douglas W. Mahoney
Filed: 27 Aug 20
Utility
Method for Stabilizing Hemoglobin and Reagents for Performing the Same
24 Nov 22
A stool resuspension solution comprising a hemoglobin stabilization reagent is provided.
Keith D. Fourrier, Jacquelyn T. Hennek, Michael J. Domanico, William G. Weisburg, Graham P. Lidgard, Kathleen S. Harings, Daniel J. Simpson
Filed: 6 Jun 22
Utility
Detecting Esophageal Disorders
3 Nov 22
Provided herein is technology for screening for esophageal disorders, including but not limited to, Barrett's esophagus (BE).
William R. Taylor, Tracy C. Yab, Douglas W. Mahoney, John B. Kisiel, David A. Ahlquist, Hatim T. Allawi, Graham P. Lidgard, Maria Giakoumopoulos
Filed: 22 Apr 22
Utility
Methylated Control Dna
27 Oct 22
Provided herein is technology relating compositions and methods for analysis of methylated DNA from a subject.
Hatim T. Allawi, Graham P. Lidgard
Filed: 10 May 22
Utility
Multiplex Amplification Detection Assay
25 Aug 22
Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA.
Graham P. Lidgard, Hatim Allawi
Filed: 11 Mar 22
Utility
Detecting the Presence or Absence of Multiple Types of Cancer
4 Aug 22
Provided herein is technology for screening multiple types of cancer from a biological sample, and particularly, but not exclusively, to methods, compositions, and related uses for simultaneously detecting the presence of multiple types of cancer (e.g., liver cancer, esophageal cancer, lung cancer, ovarian cancer, pancreatic cancer, gastric cancer, bladder cancer, breast cancer, cervical cancer, colorectal cancer, prostate cancer, renal cancer, and uterine cancer) from a biological sample (e.g., stool sample, tissue sample, organ secretion sample, CSF sample, saliva sample, blood sample, plasma sample or urine sample).
William R. Taylor, Hatim T. Allawi, Viatcheslav E. Katerov, John B. Kisiel, Douglas W. Mahoney, David A. Ahlquist
Filed: 28 Jan 22
Utility
Detecting Pancreatic Ductal Adenocarcinoma In Plasma
26 May 22
Provided herein is technology for pancreatic ductal adenocarcinoma (PDAC) screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of PDAC.
William R. Taylor, John B. Kisiel, Douglas W. Mahoney, David A. Ahlquist, Hatim T. Allawi
Filed: 3 Apr 20
Utility
Nucleic Acid Control Molecules from Non-human Organisms
5 May 22
The present invention provides synthetic DNA strands that find use as process controls in DNA processing and nucleic acid testing methods.
Hatim T. Allawi, Graham P. Lidgard, Brian Aizenstein, Melissa M. Gray
Filed: 18 Nov 21