9 patents
Utility
Improved Proteomic Multiplex Assays
12 Aug 21
Methods, devices, reagents and kits designed to improve the performance of proteomic based assays are provided.
Stephan KRAEMER, Evaldas KATILIUS, Dominic ZICHI
Filed: 19 Jun 19
Utility
Aptamer-Based Multiplexed Assays
5 Aug 21
The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample.
Glenn Sanders, Stephan Kraemer, Evaldas Katilius, EDGAR OLIVAS
Filed: 30 Mar 21
Utility
Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) Biomarkers and Uses Thereof
15 Jul 21
Methods, compositions, and kits for determining whether a subject has non-alcoholic fatty liver disease (NAFLD), and more specifically one or more of the following associated conditions of steatosis, lobular inflammation, hepatocyte ballooning and fibrosis, are provided.
Stuart Field
Filed: 7 Feb 17
Utility
Oligonucleotides Comprising Modified Nucleosides
10 Jun 21
Polynucleotides, such as aptamers, comprising at least first one 5-position modified pyrimidine and at least one second 5-position modified pyrimidine are provided, wherein the first and second 5-position modified pyrimidines are different.
Jeff Carter, Bharat Gawande, Nebojsa Janjic, Daniel Schneider
Filed: 18 Dec 20
Utility
Nucleic Acid Compounds for Binding Growth Differentiation Factor 11
6 May 21
Described herein are aptamers capable of binding to growth differentiation factor 11 (GDF11) protein; compositions comprising a GDF11 binding aptamer with a GDF11 protein; and methods of making and using the same.
Urs Ochsner, Louis Green, Dom Zichi, Nebojsa Janjic
Filed: 16 Sep 20
Utility
Cardiovascular Risk Event Prediction and Uses Thereof
27 May 20
The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the evaluation of risk of a caradiovascular (CV) Event within 5 years.
Rosalynn Dianne GILL, Stephen Alaric WILLIAMS, Alec A.E. STEWART, Robert MEHLER, Trudi FOREMAN, Britta SINGER
Filed: 22 Jan 20
Utility
Proteomic Assay Using Quantum Sensors
11 Mar 20
Apparatus and methods for the detection of proteins in biological fluids such as urine using a label-free assay is described.
Jason Paul CLEVELAND, Karoly HOLCZER, Barry Patrick John VANT-HULL
Filed: 17 Nov 19
Utility
Aptamers to PDGF and VEGF and Their Use in Treating PDGF and VEGF Mediated Conditions
19 Feb 20
Aptamers that bind PDGF and aptamers that bind VEGF are provided.
Thale C. Jarvis, John C. Rohloff, Amy D. Gelinas, Chi Zhang, Daniel W. Drolet, Sheela M. Waugh, Nebojsa Janjic
Filed: 21 Feb 19
Utility
Method for Generating Aptamers with Improved Off-Rates
30 Oct 19
The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules.
Dominic Zichi, Sheri K. Wilcox, Chris Bock, Daniel J. Schneider, Bruce Eaton, Larry Gold
Filed: 15 May 19
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