12 patents
Utility
Method for generating aptamers with improved off-rates
7 Sep 21
The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules.
Dominic Zichi, Sheri K. Wilcox, Chris Bock, Daniel J. Schneider, Bruce Eaton, Larry Gold
Filed: 16 May 19
Utility
Pancreatic cancer biomarkers and uses thereof
22 Jun 21
The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and pancreatic cancer specifically.
Stephen Alaric Williams, Michael Riel-Mehan, Rachel M. Ostroff
Filed: 17 Aug 17
Utility
Oligonucleotides comprising modified nucleosides
23 Feb 21
Polynucleotides, such as aptamers, comprising at least first one 5-position modified pyrimidine and at least one second 5-position modified pyrimidine are provided, wherein the first and second 5-position modified pyrimidines are different.
Jeff Carter, Bharat Gawande, Nebojsa Janjic, Daniel Schneider
Filed: 30 Jun 17
Utility
Nucleic acid compounds for binding growth differentiation factor 11
19 Oct 20
Described herein are aptamers capable of binding to growth differentiation factor 11 (GDF11) protein; compositions comprising a GDF11 binding aptamer with a GDF11 protein; and methods of making and using the same.
Urs Ochsner, Louis Green, Dom Zichi, Nebojsa Janjic
Filed: 22 Nov 15
Utility
Cardiovascular risk event prediction and uses thereof
1 Jun 20
Methods and computer methods used to assess an individual for the prediction of risk of developing a Cardiovascular (CV) Event over a 1 to 5 year period are provided.
David Sterling, Shintaro Kato, Edward N. Brody, Stephen A. Williams
Filed: 2 Nov 14
Utility
Multiplexed analyses of test samples
11 May 20
The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample.
James R. Heil, Daniel J. Schneider, Daniel T. Nieuwlandt, Sheri K. Wilcox, Dominic Zichi, Todd Gander, Bruce Eaton, Larry Gold
Filed: 22 Jan 18
Utility
Compounds and methods for the synthesis of 5-(N-protected-tryptaminocarboxyamide)-2′-deoxyuridine phosphoramidite for incorporation into a nucleic acid
27 Apr 20
Modified Tryptamine, Tryptamine-2′-deoxy-uridine (TrpdU) and TrpdU-phosphoramidites for oligonucleotide synthesis are provided, as well as improved methods of their synthesis and oligonucleotides comprising at least one modified TrpdU nucleotide.
John Rohloff
Filed: 12 Mar 17
Utility
Aptamers and diagnostic methods for detecting the EGF receptor
13 Apr 20
The present invention provides aptamers that specifically bind to the EGF receptor in a sample, and diagnostic and analytical methods using those aptamers.
Chris Bock, Deborah Ayers, Malti P. Nikrad, Bharat Nathu Gawande, Jennifer C. Bertino, Weimin Sun, Charles M. Strom, Noh Jin Park
Filed: 4 May 17
Utility
PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders
27 Jan 20
Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided.
Nebojsa Janjic, Daniel W. Drolet, Amy D. Gelinas, Chi Zhang, Michael Vrkljan
Filed: 9 May 18
Utility
Compositions and methods for detecting microorganisms
20 Jan 20
Described herein are compositions and methods for detecting the presence or absence of a microorganism in a sample comprising contacting the sample with an aptamer capable of binding to a cell-surface protein of the microorganism to form a complex, contacting the mixture with a second aptamer capable of binding to the first cell-surface protein or a second cell-surface protein of the microorganism; and performing an assay to detect the second aptamer, wherein detecting the second aptamer indicates that the microorganism is present in the sample, and wherein not detecting the second aptamer indicates that the microorganism is absent from the sample.
Urs A. Ochsner, Nebojsa Janjic
Filed: 30 Aug 18
Utility
Method of detecting a microorganism in a sample by a fluorescence based detection method
6 Jan 20
Anne Baumstummler, Frederic Marc-Kreucher, David Lehmann, Urs Ochsner, Nebojsa Janjic
Filed: 19 Feb 15
Utility
Proteomic assay using quantum sensors
18 Nov 19
Apparatus and methods for the detection of proteins in biological fluids such as urine using a label-free assay is described.
Jason Paul Cleveland, Karoly Holczer, Barry Patrick John Vant-Hull
Filed: 8 Mar 18
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