304 patents
Page 4 of 16
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Human Alpha-galactosidase Variants
10 Nov 22
The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof.
William Casey Hallows, Kristen Jean Vallieu, Nikki Dellas, Yu Zhu, Judy Victoria Antonio Viduya, Chinping Chng, Antoinette Sero, Gjalt W. Huisman, Rachel Cathleen Botham, Moulay Hicham Alaoui Ismaili
Filed: 22 Jul 22
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Ketoreductase polypeptides for the reduction of acetophenones
25 Oct 22
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme.
Jack Liang, Stephane J. Jenne, Emily Mundorff, Charlene Ching, John M. Gruber, Anke Krebber, Gjalt W. Huisman
Filed: 14 Jan 21
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Engineered tyrosine ammonia lyase
18 Oct 22
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof.
Joyce Liu, Nikki Dellas, Stephan Jenne
Filed: 6 Dec 19
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Engineered Adenylate Kinase Variant Enzymes
13 Oct 22
The present invention provides engineered adenylate kinase (AdK) enzymes, polypeptides having AdK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Da Duan, Auric Anthony Sowell-Kantz, Aksiniya Lyubenova Petkova, Oscar Alvizo
Filed: 1 Apr 22
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Engineered Acetate Kinase Variant Enzymes
13 Oct 22
The present invention provides engineered acetate kinase (AcK) enzymes, polypeptides having AcK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Margie Tabuga Borra-Garske, Oscar Alvizo, Lillian Jasmine Miller, Aksiniya Lyubenova Petkova
Filed: 1 Apr 22
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Engineered Guanylate Kinase Variant Enzymes
13 Oct 22
The present invention provides engineered guanylate kinase (GK) enzymes, polypeptides having GK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Da Duan, Auric Anthony Sowell-Kantz, Aksiniya Lyubenova Petkova, Oscar Alvizo
Filed: 1 Apr 22
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ENGINEERED CYCLIC GMP-AMP SYNTHASE (cGAS) VARIANT ENZYMES
13 Oct 22
The present invention provides engineered cyclic GMP-AMP synthase (cGAS) enzymes, polypeptides having cGAS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Margie Tabuga Borra-Garske, Oscar Alvizo, Lillian Jasmine Miller, Aksiniya Lyubenova Petkova
Filed: 1 Apr 22
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Engineered galactose oxidase variant enzymes
11 Oct 22
The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Christopher Michael Micklitsch, Oscar Alvizo, Jovana Nazor, Harvinder Chagger Maniar, Mikayla Jianghongxia Krawczyk, Margie Tabuga Borra-Garske, Nandhitha Subramanian, Anna Fryszkowska, Nicholas M. Marshall, Agustina Rodriguez-Granillo, Deeptak Verma, Dewan Andrews
Filed: 2 Jul 19
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Engineered Imine Reductases and Methods for the Reductive Amination of Ketone and Amine Compounds
6 Oct 22
The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
Haibin Chen, Steven J. Collier, Jovana Nazor, Joly Sukumaran, Derek Smith, Jeffrey C. Moore, Gregory Hughes, Jacob Janey, Gjalt W. Huisman, Scott J. Novick, Nicholas J. Agard, Oscar Alvizo, Gregory A. Cope, Wan Lin Yeo, Stefanie Ng Minor
Filed: 2 Jun 22
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Engineered Glycosyltransferases and Steviol Glycoside Glucosylation Methods
29 Sep 22
The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Jonathan Vroom, Stephanie Sue Galanie, Nikki Dellas, Jack Liang, Joyce Liu, David Entwistle, Courtney Dianne Moffett
Filed: 27 Oct 20
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Transaminase Reactions
15 Sep 22
The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
Gregory Hughes, Paul N. Devine, Fred J. Fleitz, Brendan T. Grau, John Limanto, Christopher Savile, Emily Mundorff
Filed: 23 May 22
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Peroxidase Activity Towards 10-ACETYL-3,7-DIHYDROXYPHENOXAZINE
15 Sep 22
The present invention provides engineered peroxidase enzymes, polypeptides having peroxidase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Da Duan, Auric Anthony Sowell-Kantz, Aksiniya Lyubenova Petkova, Jovana Nazor, Nandhitha Subramanian, Oscar Alvizo
Filed: 3 Sep 20
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Engineered Transaminase Polypeptides for Industrial Biocatalysis
8 Sep 22
The present invention provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions.
Scott J. Novick, Nikki Dellas, Oscar Alvizo, Ravi David Garcia, Charlene Ching, David Entwistle
Filed: 12 May 22
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Engineered Imine Reductases and Methods for the Reductive Amination of Ketone and Amine Compounds
1 Sep 22
The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
Oscar Alvizo, Melissa Ann Mayo, Jeffrey C. Moore
Filed: 6 May 22
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Human alpha-galactosidase variants
30 Aug 22
The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof.
William Casey Hallows, Kristen Jean Vallieu, Nikki Dellas, Yu Zhu, Judy Victoria Antonio Viduya, Chinping Chng, Antoinette Sero, Gjalt W. Huisman, Rachel Cathleen Botham, Moulay Hicham Alaoui Ismaili
Filed: 19 Dec 19
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Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
30 Aug 22
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme.
Jack S Liang, Stephan Jenne, Emily Mundorff, Rama Voladri, James J. Lalonde, Gjalt W. Huisman
Filed: 26 Oct 20
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Ketoreductase Polypeptides for the Preparation of Phenylephrine
25 Aug 22
The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.
Oscar Alvizo, Steven J. Collier, Hans-Georg Joerg Hennemann, Seong Ho Oh, Wenjuan Zha
Filed: 28 Apr 22
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Engineered tyrosine ammonia lyase
23 Aug 22
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof.
Gjalt W. Huisman, Joyce Liu, Nikki Dellas, Chinping Chng, William Casey Hallows
Filed: 14 Jan 21
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Engineered Acetate Kinase Variant Enzymes
11 Aug 22
The present invention provides engineered acetate kinase (AcK) enzymes, polypeptides having AcK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Jonathan Vroom, Alberto Ortega Guerra, Jovana Nazor, Mikayla Jianghongxia Krawczyk
Filed: 30 Jun 20
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Engineered Sucrose Phosphorylase Variant Enzymes
4 Aug 22
The present invention provides engineered sucrose phosphorylase (SP) enzymes, polypeptides having SP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Jonathan Vroom, Santhosh Sivaramakrishnan, Nandhitha Subramanian
Filed: 30 Jun 20