63 patents
Page 3 of 4
Utility
Hydroxypropyl beta-cyclodextrin compositions and methods
2 Mar 21
This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.
Bernardus Nicolaas Machielse, Allan Darling
Filed: 4 Jun 19
Utility
Processing blood
23 Feb 21
Methods (300), devices, and systems of processing blood are described.
David Peritt, Philip Wong, Janet Lesley Macpherson, Kevin Henrichsen, Geoffrey Phillip Symonds, Susan Pond
Filed: 9 May 18
Utility
Process for preparing acylated amphetamine derivatives
23 Feb 21
Processes for preparing acetylated amphetamine derivatives and, in particular, processes for preparing L-lysine-D-amphetamine dimesylate from D-amphetamine salts.
Brian Orr, Kevin Roesch, Joel McClenaghan
Filed: 27 Nov 18
Utility
Cannula for minimizing dilution of dosing during nitric oxide delivery
16 Feb 21
Described are nasal cannulas that improve the precision of the delivered dose for nitric oxide therapy by reducing the dilution of nitric oxide.
Craig Flanagan, Simon Freed, John Klaus, Thomas Kohlmann, Martin D. Meglasson, Manesh Naidu, Parag Shah
Filed: 23 Oct 17
Utility
Breathing apparatus detection and purging
2 Feb 21
Described are methods for safer nitric oxide delivery, as well as apparatuses for performing these methods.
Jaron M. Acker, Thomas Kohlmann
Filed: 23 Jan 17
Utility
Preparation of sufentanil citrate and sufentanil base
26 Jan 21
Provided herein are processes for forming sufentanil citrate from sufentanil base.
George Helmut Klemm, Brian Orr, Joel McClenaghan
Filed: 22 Jan 19
Utility
Systems and methods for intelligent gas source management and/or systems and methods for delivery of therapeutic gas and/or enhanced performance verification for therapeutic gas delivery
19 Jan 21
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient.
Jaron M. Acker, Craig R. Tolmie, Robin Roehl, Jeffrey Schmidt, Jeff Milsap
Filed: 12 Dec 18
Utility
Device and method for diffusing high concentration NO with inhalation therapy gas
19 Jan 21
Systems and methods of the present invention can enable high concentration NO to be delivered into ventilator breathing circuits, via a diffusing device, without generating undesirably large amounts of NO2.
John C. Falligant, Craig R. Tolmie
Filed: 30 Sep 16
Utility
Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate
16 Nov 20
Disclosed herein are methods of treating and preventing muscle loss using ornithine in combination with at least one of phenyl acetate and phenylbutyrate.
Christopher F. Rose, Franck Rousseau
Filed: 15 Aug 16
Utility
Systems and method for delivery of therapeutic gas to patients, in need thereof, receiving breathing gas from a ventilator that varies at least pressure and/or flow using enhanced therapeutic gas (NO) flow measurement
16 Nov 20
The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, in need thereof, receiving breathing gas from a high frequency ventilator using at least enhanced therapeutic gas (e.g., nitric oxide, NO, etc.) flow measurement.
Jaron M. Acker, Craig R. Tolmie
Filed: 7 Aug 18
Utility
Devices, methods, and systems for priming, separating, and collecting blood components
9 Nov 20
A photopheresis system (200) is disclosed, and that may be configured to execute one or more protocols.
Dennis Briggs, Simon Do, Eric Rabeno, Abdoulaye Sangare, Mark Vandlik, Vicki Fluck, Christopher Turek
Filed: 15 Jun 16
Utility
Apparatus and method for monitoring nitric oxide delivery
14 Sep 20
Described is an apparatus for monitoring nitric oxide delivery, wherein such apparatus comprises an indicator to inform a user of the apparatus when the flow of breathing gas rises above or falls below a predetermined level or range.
Robert Schnitman, Joseph J. Medicis, Jim Potenziano, Jaron Acker, Jeffrey Schmidt
Filed: 21 Aug 17
Utility
Systems and methods for providing a pulse of a therapeutic gas with a desired flow profile to maximize therapeutic effectiveness
31 Aug 20
Described are systems and methods for providing a pulse of a therapeutic gas with a desired flow profile to maximize therapeutic effectiveness.
Thomas Kohlmann, John Klaus
Filed: 18 Oct 15
Utility
Apparatus and method for filtering liquid particles from inspiratory gas flow of a patient breathing circuit affiliated with a ventilator and/or nitric oxide delivery system
17 Aug 20
The present disclosure relates to a filter apparatus for filtering liquid from a gas, the apparatus having a first housing having a gas inlet and a gas outlet; a first filter media disposed in the first housing; a second filter media disposed in the housing; and a second housing forming a first collection basin disposed in the flow path between the first filter media and the second filter media, so that a path is defined for the gas flowing from the inlet, through the first filter media, past the collection basin, through the second filter media, and to the outlet.
Scott I. Biba, John Falligant
Filed: 28 Feb 17
Utility
Hydroxypropyl beta-cyclodextrin compositions and methods
13 Jul 20
This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.
Bernardus Nicolaas Machielse, Allan Darling
Filed: 1 Apr 19
Utility
Administration and monitoring of nitric oxide in ex vivo fluids
1 Jun 20
Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids.
Jim Potenziano, Douglas R. Hansell, Jeff Griebel, Eddie Costa, Lisa Cooper, David William Newman
Filed: 9 Mar 16
Utility
High-purity large-scale preparation of stannsoporfin
25 May 20
Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
George S. Drummond, Robert Caroselli, Keith A. Cooke, Daniel Levin, David G. Roe, Christopher P. Boucher
Filed: 10 Mar 19
Utility
Nitric oxide delivery device
25 May 20
A nitric oxide delivery device including a valve assembly, a control module and a gas delivery mechanism is described.
Duncan P. Bathe, John Klaus, David Christensen
Filed: 6 Jul 16
Utility
Support for centrifuge tubing
4 May 20
The current disclosure presents embodiments directed to, among others, a support and/or clamp (60) for receiving a cylindrical element (e.g., a bearing (90)), which can include a base (62), a pair of opposed receiving members (64) projecting from the base (62) and spaced apart from one other to establish a receiving area (66) configured with a size and shape to removably receive at least one of a circular, cylindrical and spherical object therein, and at least one of a detent (24) and magnet (40) arranged within at least a portion of the receiving area (66), the detent (24) and/or magnet (40) configured to at least one of temporarily retain the object within the receiving area (66) and establish a sound associated with the receiving of the object.
Mark Vandlik, Shaun Wall, Josef Gabelberger, Eric Rabeno
Filed: 4 May 16
Utility
Extended release, abuse deterrent dosage forms
20 Apr 20
Extended release, abuse deterrent dosage forms comprising crush-resistant controlled-release particles that provide abuse deterrent properties to the dosage forms.
Jonathan Gaik, Jaehan Park, Ryan Lathrop, Gary Nichols, John Schallom
Filed: 20 Mar 17