10 patents
Utility
Improved Assays to Detect Nucleosome Modifications Using Antibody-targeted Enzyme Digestion
28 Dec 23
This present invention relates to methods for improved assays to quantify the level of chromatin targets from biological samples.
Matthew R. Marunde, Nathan W. Hall, Zu-Wen Sun, Martis W. Cowles, Andrea L. Johnstone, Michael-Christopher Keogh, Ellen Weinzapfel, Kelsey Noll
Filed: 2 Nov 21
Utility
Methods for Quantification of Nucleosome Modifications and Mutations at Genomic Loci and Clinical Applications Thereof
21 Dec 23
The invention relates to clinical applications of quantitative chromatin mapping assays, such as chromatin immunoprecipitation assays and assays using tethered enzymes (e.g., chromatin immunocleavage (ChIC) and cleavage under targets & release using nuclease (CUT&RUN®)).
Martis William Cowles, Michael-Christopher Keogh
Filed: 11 Apr 23
Utility
Quantitative Mapping of Chromatin Associated Proteins
17 Feb 22
The present invention relates to DNA-barcoded recombinant nucleosomes and polynucleosomes that have been engineered for use as spike-in controls for the quantitative mapping of chromatin associated proteins using Chromatin ImmunoPrecipitation (ChIP) assays, tethered enzyme-based mapping assays, and other chromatin mapping assays.
Martis W. Cowles, Zu Wen Sun, Michael-Christopher Keogh
Filed: 14 Feb 20
Utility
Chromatin Mapping Assays and Kits Using Long-read Sequencing
17 Feb 22
This present invention relates to methods for carrying out chromatin mapping assays that use enzymes to incorporate barcoded DNA at targeted genomic regions followed by long-read sequencing (e.g., Third Generation Sequencing (TGS)).
Zu-Wen Sun, Martis W. Cowles, Michael-Christopher Keogh, Ellen N. Weinzapfel
Filed: 11 Feb 20
Utility
Dna-barcoded Nucleosomes for Chromatin Mapping Assays
10 Feb 22
The present invention relates to DNA-barcoded recombinant nucleosomes and polynucleosomes that have been engineered for use as spike-in controls for chromatin accessibility assays, chromatin mapping assays, e.g., using tethered enzymes, as well as other chromatin assays.
Martis W. Cowles, Zu-Wen Sun, Michael-Christopher Keogh, Bryan Jacob Venters, Ellen Nichole Weinzapfel
Filed: 20 Dec 19
Utility
Peptide Ligase-mediated Engineering of Recombinant Nucleosomes
11 Feb 21
The invention relates generally to methods for preparing recombinant nucleosomes.
Martis William Cowles, Michael-Christopher Keogh, Jonathan M. Burg, Zu-Wen Sun
Filed: 7 Mar 19
Utility
Quantification of Nucleosome Modifications Using Chemically-defined Recombinant Nucleosomes
14 Jan 21
The invention relates to the use of recombinant/semi-synthetic nucleosomes carrying histone and/or DNA modifications as a reference standard for quantification of covalently modified (on the histone proteins or wrapping DNA), variant, or mutant nucleosomes (collectively “modified nucleosomes” or “nucleosome modifications”) from a biological sample.
Martis William Cowles, Matthew F. Whelihan, Andrea L. Johnstone, Michael-Christopher Koegh, Zu-Wen Sun, Nathan W. Hall, Matthew R. Marunde
Filed: 24 Jul 20
Utility
Methods for Quantification of Nucleosome Modifications and Mutations at Genomic Loci and Clinical Applications Thereof
21 Oct 20
The invention relates to clinical applications of quantitative chromatin mapping assays, such as chromatin immunoprecipitation assays and assays using tethered enzymes (e.g., chromatin immunocleavage (ChIC) and cleavage under targets & release using nuclease (CUT&RUN®)).
Martis William Cowles, Michael-Christopher Keogh
Filed: 9 Jan 19
Utility
Assays for Nucleosome Remodeling Activity
24 Jun 20
The invention relates to assays for nucleosome remodeling activity using functionalized recombinant mononucleosomes.
Michael-Christopher Keogh, Martis William Cowles, Matthew Fruge Whelihan
Filed: 17 May 18
Utility
Quantification of Nucleosome Modifications Using Chemically-defined Recombinant Nucleosomes
4 Mar 20
The invention relates to the use of recombinant/semi-synthetic nucleosomes carrying histone and/or DNA modifications as a reference standard for quantification of covalently modified (on the histone proteins or wrapping DNA), variant, or mutant nucleosomes (collectively “modified nucleosomes” or “nucleosome modifications”) from a biological sample.
Martis William Cowles, Matthew F. Whelihan, Andrea L. Johnstone, Michael-Christopher Koegh, Zu-Wen Sun, Nathan W. Hall, Matthew R. Marunde
Filed: 7 Nov 19
- Prev
- 1
- Next
Patents are sorted by USPTO publication date, most recent first