193 patents
Page 7 of 10
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
6 May 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli TALASAZ
Filed: 11 Jan 21
Utility
Systems and methods to detect rare mutations and copy number variation
4 May 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz
Filed: 11 Jan 21
Utility
Methods for 3' Overhang Repair
29 Apr 21
Methods of repairing a partially double-stranded DNA fragment are provided.
Eleen SHUM
Filed: 23 Oct 20
Utility
Methods and Systems for Analysis of CTCF Binding Regions In Cell-free Dna
29 Apr 21
The present disclosure provides systems and methods to analyze CTCF binding regions in cell-free DNA (cfDNA) from a subject to detect tumor-originating cfDNA.
Elena ZOTENKO
Filed: 28 Dec 20
Utility
Compositions and Methods for Analyzing Cell-free Dna In Methylation Partitioning Assays
22 Apr 21
Provided herein is a DNA analysis method comprising partitioning a sample into at least a first subsample and a second subsample, wherein the first subsample comprises DNA (e.g., cell-free DNA) with a cytosine modification in a greater proportion; the first subsample undergoes a procedure that affects a first nucleobase in the DNA differently from a second nucleobase in the DNA of the first subsample; and DNA is sequenced to distinguish the first nucleobase from the second nucleobase.
Stefanie Ann Ward MORTIMER, William J. GREENLEAF
Filed: 30 Sep 20
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
8 Apr 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli TALASAZ, Stefanie Ann Ward MORTIMER
Filed: 14 Oct 20
Utility
Systems and methods to detect rare mutations and copy number variation
30 Mar 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz
Filed: 10 Dec 19
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
25 Mar 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli TALASAZ, Stefanie Ann Ward MORTIMER
Filed: 13 Oct 20
Utility
Systems and methods to detect rare mutations and copy number variation
16 Mar 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz
Filed: 12 Oct 20
Utility
Cancer Evolution Detection and Diagnostic
18 Feb 21
The present disclosure provides methods for determining a probability that after any of a number of therapeutic interventions, an initial state of a subject, such as somatic cell mutational status of a subject with cancer, will develop a subsequent state.
Helmy ELTOUKHY, AmirAli TALASAZ
Filed: 3 Sep 20
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
11 Feb 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli TALASAZ, Stefanie Ann Ward MORTIMER
Filed: 13 Oct 20
Utility
Detection and Treatment of Disease Exhibiting Disease Cell Heterogeneity and Systems and Methods for Communicating Test Results
11 Feb 21
This disclosure provides, among other things, methods for generating and applying therapeutic interventions.
Helmy ELTOUKHY, AmirAli TALASAZ, Bahram Ghaffarzadeh KERMANI, Nnamdi IHUEGBU
Filed: 21 Aug 20
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
4 Feb 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli TALASAZ
Filed: 12 Oct 20
Utility
Methods and Systems for Improving Patient Monitoring after Surgery
21 Jan 21
In an aspect, a method for detecting the presence or absence of cancer in a subject comprises: (a) obtaining samples from the subject from different time points, wherein a first sample obtained at first time point is a polynucleotide sample from a tumor tissue specimen and a second sample obtained at second time point is a cell-free polynucleotide sample from a blood sample; (b) processing polynucleotides from each of the samples, comprising: i) tagging at least a portion of the polynucleotides, thereby generating tagged parent polynucleotides; ii) amplifying at least a portion of the tagged parent polynucleotides to generate progeny polynucleotides; iii) enriching at least a portion of the progeny polynucleotides for target genomic regions; thereby generating enriched polynucleotides; and iv) sequencing at least a portion of the enriched polynucleotides to generate sequencing reads; and (c) analyzing genomic regions for at least one epigenetic feature from the sequencing reads.
Ariel JAIMOVICH, Yupeng HE, Oscar WESTESSON, William J. GREENLEAF
Filed: 1 Jun 20
Utility
Systems and methods to detect rare mutations and copy number variation
19 Jan 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz, Stefanie Ann Ward Mortimer
Filed: 4 Aug 17
Utility
Methods and systems for detecting genetic variants
12 Jan 21
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Stefanie Ann Ward Mortimer
Filed: 13 Dec 19
Utility
Methods and systems for detecting genetic variants
4 Jan 21
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
Helmy Eltoukhy, AmirAli Talasaz, Stefanie Ann Ward Mortimer
Filed: 7 Feb 18
Utility
Systems and methods to detect rare mutations and copy number variation
28 Dec 20
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz, Stefanie Ann Ward Mortimer
Filed: 18 Apr 19
Utility
Systems and methods to detect rare mutations and copy number variation
28 Dec 20
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz
Filed: 26 May 20
Utility
Systems and methods to detect rare mutations and copy number variation
28 Dec 20
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz
Filed: 8 Jun 20