122 patents
Page 2 of 7
Utility
Glaucoma Treatment Via Intracameral Ocular Implants
14 Sep 23
The disclosure teaches methods of utilizing precisely engineered biodegradable drug delivery systems to treat intraocular conditions.
Tomas Navratil, Sanjib Das, Andres Garcia, Janet Tully
Filed: 11 Aug 22
Utility
Biodegradable ALPHA-2 Agonist Polymeric Implants and Therapeutic Uses Thereof
14 Sep 23
Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time.
Lon T. Spada, Alazar N. Ghebremeskel, Michael R. Robinson
Filed: 15 Jul 22
Utility
Microneedle Arrays Formed from Polymer Films
7 Sep 23
An active agent can be administered transdermally to a patient by using a transdermal patch that has microneedles that are compositionally homogenous with a base layer.
Roger L. KASPAR, Tycho Speaker
Filed: 9 Nov 22
Utility
Coacervate Hyaluronan Hydrogels for Dermal Filler Applications
7 Sep 23
The present disclosure provides dermal fillers comprising hyaluronic acid-based hydrogels.
Futian Liu, Xiaojie Yu, Dennis E. Van Epps, Iossif A. Strehin
Filed: 11 Oct 22
Utility
Immuno-based Botulinum Toxin Serotype a Activity Assays
7 Sep 23
The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
Ester Fernandez-Salas, Joanne Wang, Patton E. Garay, Lina Wong, D. Dianne Hodges, Kei Roger Aoki
Filed: 29 Sep 22
Utility
Compositions Comprising Tropoelastin Crosslinked to Hyaluronic Acid and the Methods of Use Thereof
17 Aug 23
Soft tissue conditions can be treated by administering a composition comprising tropoelastin including, for example, a composition comprising tropoelastin crosslinked to hyaluronic acid to increase moisture content in the soft tissue.
Robert DANIELS, Christopher K. HEE, Anthony S. WEISS, Michal Graff MITZMACHER, Suzanne M. MITHIEUX
Filed: 14 May 21
Utility
Formulations of Biologics for Intravesical Instillation
17 Aug 23
Pharmaceutical formulations comprising a clostridial derivative and a permeabilizing agent for intravesical instillation are disclosed.
Eric A. Forssen, Patrick M. Hughes, David C. Rupp, Terrence J. Hunt, Gary Shimizu, Joseph Francis, Ron S. Broide, Ester Fernandez-Salas, Catherine Rheaume
Filed: 16 Sep 22
Utility
Formulations of Biologics for Intravesical Instillation
17 Aug 23
Pharmaceutical formulations comprising a clostridial derivative and a permeabilizing agent for intravesical instillation are disclosed.
Eric A. Forssen, Patrick M. Hughes, David C. Rupp
Filed: 26 Sep 22
Utility
Tissue Expansion Device with Fluid Collection
10 Aug 23
A tissue expander can be configured to collect extracellular fluid from within a patient’s body cavity.
David J. Schuessler
Filed: 9 Jul 21
Utility
Macrogol 15 Hydroxystearate Formulations
3 Aug 23
Provided herein are compositions, which include an active pharmaceutical ingredient and macrogol 15 hydroxystearate, and methods for using the same for treating diseases or disorder.
Anuradha V. Gore, Kevin S. Warner, Chetan P. Pujara, Richard S. Graham, Ajay P. Parashar, Mu-Lan Lee, Robert S. Jordan, Sukhon Likitlersuang
Filed: 5 Apr 23
Utility
Methods and Compositions for Categorizing And/or Treating Chin Retrusion In a Subject In Need Thereof
3 Aug 23
The disclosure provides methods and compositions for treating or categorizing chin retrusion in a subject such as an East Asian subject.
Jiazhi Qu, Yi Jia, Dong Li
Filed: 17 Jun 21
Utility
Immuno-based Botulinum Toxin Serotype a Activity Assays
27 Jul 23
The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
Ester Fernandez-Salas, Joanne Wang, Patton E. Garay, Lina Wong, D. Dianne Hodges, Kei Roger Aoki
Filed: 17 Aug 22
Utility
CGRP Antagonists and Clostridial Derivatives for the Treatment of Neuropsychiatric and Neurological Disorders
25 May 23
Methods for treating neurological or neuropsychiatric disorder and related symptoms by administering a CGRP antagonist and a Clostridial derivative are described.
Mitchell F. Brin, Andrew M. Blumenfeld
Filed: 27 Jun 22
Utility
Clostridial Toxin - Hyaluronic Acid Compositions
25 May 23
Pharmaceutical compositions that extend the effect and duration of a Clostridial toxin active ingredient are described.
Cindy WU, James Cunningham, Marianne Do, Ron Broide
Filed: 30 Jun 22
Utility
Treatment of Major Depressive Disorder
18 May 23
The present disclosure provides methods for the treatment of major depressive disorder by administering cariprazine or a pharmaceutically acceptable salt thereof.
Kumar Budur, Ludmyla Rekeda, Willie R. Earley
Filed: 28 Oct 22
Utility
Delayed Release Compositions of Linaclotide
11 May 23
The present invention relates to delayed release pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
Angelika Fretzen, Mark G. Currie, Ahmad Hashash, Mahendra Dedhiya, Yun Mo, Anil Chhettry, Matthew Miller, Ritesh Sanghvi, Mohammad Mafruhul Bari, Andreas Grill
Filed: 30 Dec 22
Utility
Methods for Treating and for Inhibiting Progression of Seizures
11 May 23
Methods for treating seizures and for inhibiting progression of a focal seizure to a generalized seizure by administering extracranially a Clostridial derivative are described.
Rami Burstein, Agustin Melo Carrillo, Mitchell F. Brin
Filed: 16 Aug 22
Utility
Drain-compatible Tissue Expansion Device
27 Apr 23
A drain-compatible soft tissue expander can incorporate a drainage structure that allows fluid to be removed from the body of a living subject.
David J. SCHUESSLER, Gina M. NUTI
Filed: 23 Apr 21
Utility
Methods of Treating Migraine
27 Apr 23
The present disclosure provides methods for the treatment of migraine by the administration of atogepant or a pharmaceutically acceptable salt thereof.
Ramesh Boinpally, Joel Trugman
Filed: 27 Sep 22
Utility
Thread Insertion Device
27 Apr 23
The disclosure relates to a device for creating an intradermal channel in a skin tissue of a patient, with a thread.
David Dadi SEGAL, Liat GOLDSHAID-ZMIRI, Lital SHKLANOVSKY, Eran GOLDBERG, Yehonatan COHEN, Naor MARCIANO
Filed: 1 Mar 21